Details of the Target

General Information of Target

Target ID LDTP14968
Target Name Probable ATP-dependent RNA helicase DDX60-like (DDX60L)
Gene Name DDX60L
Gene ID 91351
Synonyms
Probable ATP-dependent RNA helicase DDX60-like; EC 3.6.4.13; DEAD box protein 60-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVGKSQQTDVIEKKKHMAIPKSSSPKATHRIGNTSGSKGSYSAKAYESIRVSSELQQTWT
KRKHGQEMTSKSLQTDTIVEEKKEVKLVEETVVPEEKSADVREAAIELPESVQDVEIPPN
IPSVQLKMDRSQQTSRTGYWTMMNIPPVEKVDKEQQTYFSESEIVVISRPDSSSTKSKED
ALKHKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPVLLEDELREEVTV
PVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEET
PDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESPS
EEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEET
LADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEEASAEIQLLAAT
EPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPA
EAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATE
ASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQP
PPAEEAPAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPAEEASVDKHSPP
ADLLLTEEFPIGEASAEVSPPPSEQTPEDEALVENVSTEFQSPQVAGIPAVKLGSVVLEG
EAKFEEVSKINSVLKDLSNTNDGQAPTLEIESVFHIELKQRPPEL
Target Bioclass
Enzyme
Family
Helicase family
Uniprot ID
Q5H9U9
Ensemble ID
ENST00000505890.5
HGNC ID
HGNC:26429

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C502(0.99)  LDD2094  [1]
Acrolein
 Probe Info  		N.A.  LDD0229  [2]
IA-alkyne
 Probe Info  		C1031(20.00)  LDD1703  [3]
DBIA
 Probe Info  		C502(0.85)  LDD0078  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
TFBX
 Probe Info  		C1127(0.00); C1634(0.00)  LDD0148  [5]
YN-1
 Probe Info  		D1200(0.00); D1205(0.00); D515(0.00); E1199(0.00)  LDD0447  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C320(0.78)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C320(1.39)  LDD0532  [4]
 LDCM0226  AC11 HCT 116 C320(1.35)  LDD0543  [4]
 LDCM0230  AC113 PaTu 8988t C320(1.00)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C320(0.97)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C320(0.96)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C320(1.12)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C320(1.00)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C320(1.22)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C320(1.07)  LDD1115  [4]
 LDCM0237  AC12 HCT 116 C320(1.70)  LDD0554  [4]
 LDCM0238  AC120 PaTu 8988t C320(1.07)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C320(1.06)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C320(1.16)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C320(1.01)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C320(1.23)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C320(0.97)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C320(1.31)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C320(1.26)  LDD1124  [4]
 LDCM0259  AC14 HCT 116 C320(0.79)  LDD0576  [4]
 LDCM0270  AC15 HCT 116 C320(0.91)  LDD0587  [4]
 LDCM0276  AC17 PaTu 8988t C320(1.45)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C320(1.25)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C320(1.30)  LDD1157  [4]
 LDCM0279  AC2 HCT 116 C320(1.00)  LDD0596  [4]
 LDCM0280  AC20 PaTu 8988t C320(1.15)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C320(1.17)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C320(1.41)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C320(1.31)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C320(1.39)  LDD1163  [4]
 LDCM0290  AC3 HCT 116 C320(0.73)  LDD0607  [4]
 LDCM0296  AC35 HCT 116 C320(0.86)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C320(1.19)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C320(1.16)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C320(1.10)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C320(1.37)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C320(0.83)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C320(1.48)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C320(1.15)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C320(0.99)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C320(1.07)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C320(1.01)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C320(1.05)  LDD0624  [4]
 LDCM0308  AC46 PaTu 8988t C320(1.04)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C320(1.47)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C320(1.03)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C320(1.37)  LDD1190  [4]
 LDCM0312  AC5 HCT 116 C320(0.83)  LDD0629  [4]
 LDCM0313  AC50 PaTu 8988t C320(1.13)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C320(0.56)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C320(1.07)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C320(1.19)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C320(0.98)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C320(1.05)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C320(1.08)  LDD1198  [4]
 LDCM0323  AC6 HCT 116 C320(0.87)  LDD0640  [4]
 LDCM0332  AC68 PaTu 8988t C320(1.73)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C320(1.25)  LDD1212  [4]
 LDCM0334  AC7 HCT 116 C320(1.11)  LDD0651  [4]
 LDCM0335  AC70 PaTu 8988t C320(1.38)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C320(1.29)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C320(1.42)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C320(1.28)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C320(1.73)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C320(1.35)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C320(1.36)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C320(1.44)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C320(1.36)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C320(1.53)  LDD1223  [4]
 LDCM0345  AC8 HCT 116 C320(0.87)  LDD0662  [4]
 LDCM0346  AC80 PaTu 8988t C320(1.40)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C320(1.32)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C320(1.41)  LDD1227  [4]
 LDCM0248  AKOS034007472 HCT 116 C320(1.50)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C320(1.41)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C320(1.03)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C502(0.85)  LDD0078  [4]
 LDCM0367  CL1 PaTu 8988t C320(1.14)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C320(1.20)  LDD1247  [4]
 LDCM0369  CL100 HCT 116 C320(1.04)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C320(1.17)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C320(1.34)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C320(1.58)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C320(1.88)  LDD0690  [4]
 LDCM0374  CL105 PaTu 8988t C320(0.98)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C320(1.27)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C320(1.22)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C320(1.19)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C320(1.39)  LDD1257  [4]
 LDCM0379  CL11 PaTu 8988t C320(0.63)  LDD1258  [4]
 LDCM0380  CL110 PaTu 8988t C320(1.36)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C320(1.22)  LDD1260  [4]
 LDCM0387  CL117 HCT 116 C320(1.62)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C320(1.30)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C320(1.18)  LDD0706  [4]
 LDCM0390  CL12 PaTu 8988t C320(0.90)  LDD1269  [4]
 LDCM0391  CL120 HCT 116 C320(1.03)  LDD0708  [4]
 LDCM0392  CL121 PaTu 8988t C320(0.99)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C320(1.08)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C320(1.79)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C320(1.09)  LDD1274  [4]
 LDCM0400  CL13 PaTu 8988t C320(1.18)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C320(0.91)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C320(0.99)  LDD1281  [4]
 LDCM0403  CL16 PaTu 8988t C320(1.07)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C320(1.34)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C320(0.97)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C320(0.80)  LDD1285  [4]
 LDCM0407  CL2 PaTu 8988t C320(0.86)  LDD1286  [4]
 LDCM0408  CL20 PaTu 8988t C320(1.19)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C320(1.41)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C320(0.91)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C320(1.48)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C320(0.93)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C320(0.81)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C320(1.05)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C320(1.23)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C320(0.94)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C320(1.09)  LDD1296  [4]
 LDCM0418  CL3 PaTu 8988t C320(1.25)  LDD1297  [4]
 LDCM0419  CL30 PaTu 8988t C320(1.54)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C320(1.20)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C320(1.26)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C320(1.35)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C320(1.39)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C320(1.28)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C320(0.45)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C320(1.06)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C320(1.36)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C320(0.86)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C320(1.12)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C320(1.57)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C320(1.67)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C320(1.56)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C320(1.36)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C320(1.54)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C320(0.90)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C320(1.08)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C320(1.02)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C320(1.01)  LDD1318  [4]
 LDCM0440  CL5 PaTu 8988t C320(1.16)  LDD1319  [4]
 LDCM0441  CL50 PaTu 8988t C320(1.28)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C320(1.37)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C320(1.12)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C320(1.01)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C320(1.26)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C320(0.89)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C320(1.28)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C320(1.06)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C320(1.14)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C320(1.02)  LDD1329  [4]
 LDCM0451  CL6 PaTu 8988t C320(0.98)  LDD1330  [4]
 LDCM0452  CL60 PaTu 8988t C320(1.11)  LDD1331  [4]
 LDCM0453  CL61 HCT 116 C320(1.35)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C320(0.94)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C320(0.81)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C320(1.04)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C320(0.88)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C320(0.83)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C320(0.75)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C320(0.81)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C320(1.05)  LDD0778  [4]
 LDCM0462  CL7 PaTu 8988t C320(1.27)  LDD1341  [4]
 LDCM0463  CL70 HCT 116 C320(0.97)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C320(1.02)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C320(1.19)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C320(0.91)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C320(0.82)  LDD0784  [4]
 LDCM0469  CL76 PaTu 8988t C320(1.36)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C320(1.51)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C320(1.29)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C320(1.52)  LDD1351  [4]
 LDCM0473  CL8 PaTu 8988t C320(1.04)  LDD1352  [4]
 LDCM0474  CL80 PaTu 8988t C320(1.31)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C320(1.76)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C320(1.81)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C320(1.48)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C320(1.51)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C320(1.37)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C320(1.68)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C320(1.28)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C320(1.46)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C320(1.59)  LDD1362  [4]
 LDCM0484  CL9 PaTu 8988t C320(1.61)  LDD1363  [4]
 LDCM0485  CL90 PaTu 8988t C320(1.70)  LDD1364  [4]
 LDCM0486  CL91 HCT 116 C320(0.93)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C320(1.10)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C320(1.04)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C320(0.73)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C320(0.93)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C320(1.05)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C320(0.89)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C320(0.94)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C320(0.99)  LDD0811  [4]
 LDCM0468  Fragment33 HCT 116 C320(1.14)  LDD0785  [4]
 LDCM0427  Fragment51 PaTu 8988t C320(1.61)  LDD1306  [4]
 LDCM0022  KB02 T cell C1031(20.00)  LDD1703  [3]
 LDCM0023  KB03 Jurkat C1634(18.92)  LDD0209  [8]
 LDCM0024  KB05 G361 C938(2.58); C823(2.45); C798(2.47)  LDD3311  [9]
 LDCM0109  NEM HeLa N.A.  LDD0229  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C502(0.99)  LDD2094  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C502(1.05)  LDD2141  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840