Details of the Target

General Information of Target

Target ID LDTP14945
Target Name Zinc finger protein 394 (ZNF394)
Gene Name ZNF394
Gene ID 84124
Synonyms
ZKSCAN14; Zinc finger protein 394; Zinc finger protein with KRAB and SCAN domains 14
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEVTTRLTWNDENHLRKLLGNVSLSLLYKSSVHGGSIEDMVERCSRQGCTITMAYIDYNM
IVAFMLGNYINLHESSTEPNDSLWFSLQKKNDTTEIETLLLNTAPKIIDEQLVCRLSKTD
IFIICRDNKIYLDKMITRNLKLRFYGHRQYLECEVFRVEGIKDNLDDIKRIIKAREHRNR
LLADIRDYRPYADLVSEIRILLVGPVGSGKSSFFNSVKSIFHGHVTGQAVVGSDITSITE
RYRIYSVKDGKNGKSLPFMLCDTMGLDGAEGAGLCMDDIPHILKGCMPDRYQFNSRKPIT
PEHSTFITSPSLKDRIHCVAYVLDINSIDNLYSKMLAKVKQVHKEVLNCGIAYVALLTKV
DDCSEVLQDNFLNMSRSMTSQSRVMNVHKMLGIPISNILMVGNYASDLELDPMKDILILS
ALRQMLRAADDFLEDLPLEETGAIERALQPCI
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q53GI3
Ensemble ID
ENST00000337673.7
HGNC ID
HGNC:18832

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.P259S .
HCT15 SNV: p.A137V .
JURKAT SNV: p.T308I .
MEWO SNV: p.P524L .
NCIH2172 SNV: p.W19Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C128(1.21); C235(0.90)  LDD1492  [1]
HHS-465
 Probe Info  		K523(0.00); K526(0.00); Y525(0.00)  LDD2240  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C128(1.06)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C128(0.70)  LDD1508  [1]
 LDCM0237  AC12 HEK-293T C128(1.26)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C128(0.74)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C128(0.76)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C128(0.87)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C128(0.74)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C128(0.97)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C128(1.04)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C128(0.77); C235(1.03)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C128(0.73)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C128(1.12)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C128(1.12); C235(1.05)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C128(0.90)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C128(0.69)  LDD1525  [1]
 LDCM0288  AC28 HEK-293T C128(1.58)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C128(1.40); C235(1.15)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C128(0.77)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C128(0.88)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C128(1.07); C235(1.15)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C128(1.27)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C128(0.91)  LDD1534  [1]
 LDCM0297  AC36 HEK-293T C128(1.33)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C128(0.86); C235(1.05)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C128(0.64)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C128(1.04)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C128(1.12)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C128(1.15); C235(1.03)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C128(1.18)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C128(0.75)  LDD1543  [1]
 LDCM0306  AC44 HEK-293T C128(1.37)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C128(1.07); C235(1.08)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C128(0.89)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C128(0.86)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C128(1.20); C235(1.24)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C128(0.87)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C128(0.90); C235(0.91)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C128(0.89)  LDD1552  [1]
 LDCM0315  AC52 HEK-293T C128(1.62)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C128(0.94); C235(1.09)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C128(0.95)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C128(1.18)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C128(0.83); C235(1.00)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C128(0.69)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C128(0.99)  LDD1560  [1]
 LDCM0323  AC6 HEK-293T C128(0.69)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C128(1.22)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C128(0.81); C235(1.07)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C128(1.25)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C128(1.20)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C128(1.04); C235(0.87)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C128(0.95)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C128(0.84); C235(1.03)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C128(0.90); C235(1.10)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C128(1.08)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C128(0.82); C235(1.10)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C128(1.04)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C128(1.14)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C128(0.83)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C128(0.92)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C128(0.94)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C128(0.91)  LDD1583  [1]
 LDCM0383  CL113 HEK-293T C128(0.96)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C128(1.06)  LDD1591  [1]
 LDCM0390  CL12 HEK-293T C128(0.91); C235(1.13)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C128(0.81)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C128(1.04)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C128(1.04)  LDD1604  [1]
 LDCM0404  CL17 HEK-293T C128(1.00)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C128(0.89)  LDD1609  [1]
 LDCM0408  CL20 HEK-293T C128(1.53)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C128(1.31); C235(1.25)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C128(0.82)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C128(0.95)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C128(0.87); C235(1.29)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C128(0.95)  LDD1617  [1]
 LDCM0417  CL29 HEK-293T C128(0.95)  LDD1621  [1]
 LDCM0419  CL30 HEK-293T C128(1.14)  LDD1623  [1]
 LDCM0421  CL32 HEK-293T C128(1.07)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C128(1.09); C235(0.98)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C128(0.72)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C128(0.90)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C128(0.95); C235(1.41)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C128(0.88)  LDD1630  [1]
 LDCM0431  CL41 HEK-293T C128(0.91)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C128(0.90)  LDD1636  [1]
 LDCM0434  CL44 HEK-293T C128(0.93)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C128(1.03); C235(1.15)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C128(0.90)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C128(0.77)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C128(0.98); C235(1.01)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C128(0.98)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C128(0.97)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C128(0.73)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C128(0.67)  LDD1648  [1]
 LDCM0447  CL56 HEK-293T C128(1.31)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C128(1.17); C235(1.35)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C128(0.88)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C128(0.91)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C128(0.94)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C128(0.99); C235(1.37)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C128(1.30)  LDD1656  [1]
 LDCM0457  CL65 HEK-293T C128(1.33)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C128(0.86)  LDD1661  [1]
 LDCM0460  CL68 HEK-293T C128(1.61)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C128(0.80); C235(0.99)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C128(0.80)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C128(0.96)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C128(1.02); C235(1.42)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C128(0.96)  LDD1669  [1]
 LDCM0470  CL77 HEK-293T C128(0.80)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C128(0.71)  LDD1674  [1]
 LDCM0473  CL8 HEK-293T C128(1.16)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C128(1.50)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C128(1.20); C235(1.02)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C128(0.98)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C128(0.74)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C128(1.00); C235(1.00)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C128(1.12)  LDD1682  [1]
 LDCM0483  CL89 HEK-293T C128(1.07)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C128(0.98); C235(1.06)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C128(0.66)  LDD1688  [1]
 LDCM0487  CL92 HEK-293T C128(0.94)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C128(1.03); C235(1.02)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C128(0.86)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C128(1.12)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C128(0.96); C235(0.71)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C128(0.98)  LDD1695  [1]
 LDCM0022  KB02 HEK-293T C128(1.21); C235(0.90)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C128(1.14); C235(1.06)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C128(1.00); C235(0.85)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010