Details of the Target

General Information of Target

Target ID LDTP14927
Target Name Cytochrome c oxidase assembly protein COX19 (COX19)
Gene Name COX19
Gene ID 90639
Synonyms
Cytochrome c oxidase assembly protein COX19; hCOX19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWCASPVAVVAFCAGLLVSHPVLTQGQEAGGRPGADCEVCKEFLNRFYKSLIDRGVNFSL
DTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEKLKKLD
SQICELKYEKTLDLASVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKYAA
THPKTEL
Target Bioclass
Other
Family
COX19 family
Subcellular location
Cytoplasm, cytosol
Function
Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase.
Uniprot ID
Q49B96
Ensemble ID
ENST00000344111.4
HGNC ID
HGNC:28074

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C40(3.72); C51(3.72)  LDD0080  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_5
 Probe Info  		C61(0.00); C30(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C40(0.66)  LDD0813  [1]
 LDCM0216  AC100 HEK-293T C51(1.80)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C51(1.74)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C51(1.10)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C51(1.88)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C51(1.64)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C51(1.64)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C51(1.26)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C51(2.34)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C51(1.11)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C51(1.44)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C40(1.24)  LDD0824  [1]
 LDCM0227  AC110 HEK-293T C51(4.32)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C51(1.60)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C51(2.15)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C51(0.69)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C51(0.99)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C51(0.94)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C51(1.09)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C51(0.92)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C51(1.12)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C51(1.13)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C40(1.60)  LDD0835  [1]
 LDCM0238  AC120 HEK-293T C51(0.89)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C51(0.90)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C51(0.93)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C51(1.02)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C51(1.24)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C51(0.95)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C51(1.10)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C51(1.22)  LDD0843  [1]
 LDCM0259  AC14 HEK-293T C40(1.07)  LDD0857  [1]
 LDCM0270  AC15 HEK-293T C40(0.61)  LDD0868  [1]
 LDCM0276  AC17 HEK-293T C40(0.70)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C40(0.90)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C40(0.90)  LDD0876  [1]
 LDCM0280  AC20 HEK-293T C40(0.73)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C40(0.64)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C40(0.66)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C40(0.77)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C40(0.79)  LDD0882  [1]
 LDCM0296  AC35 HEK-293T C51(0.75)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C51(0.62)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C51(0.75)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C51(0.73)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C51(0.81)  LDD0898  [1]
 LDCM0302  AC40 HEK-293T C51(0.67)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C51(0.77)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C51(0.73)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C51(0.77)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C51(0.82)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C51(0.69)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C40(0.91); C51(1.27)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C40(0.84); C51(1.24)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C40(0.90); C51(1.41)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C40(1.04); C51(1.24)  LDD0909  [1]
 LDCM0313  AC50 HEK-293T C40(0.99); C51(0.83)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C40(1.29); C51(1.18)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C40(1.10); C51(1.18)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C40(1.07); C51(1.12)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C40(1.02); C51(1.45)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C40(0.88); C51(1.24)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C40(1.28); C51(1.57)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C51(0.99)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C51(1.16)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C51(1.26)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C40(1.29)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C51(2.17)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C51(1.24)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C51(1.20)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C51(1.27)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C51(1.06)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C51(0.98)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C51(1.06)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C51(1.00)  LDD0929  [1]
 LDCM0334  AC7 HEK-293T C40(1.63)  LDD0932  [1]
 LDCM0345  AC8 HEK-293T C40(0.84)  LDD0943  [1]
 LDCM0349  AC83 HEK-293T C51(1.06)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C51(1.13)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C51(0.82)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C51(1.02)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C51(1.14)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C51(0.78)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C51(1.50)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C51(0.94)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C51(1.06)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C51(0.78)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C51(0.96)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C51(0.84)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C51(1.11)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C51(1.13)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C51(1.93)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C51(2.27)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C51(2.20)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C40(1.01)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C40(0.80)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C40(0.97)  LDD0873  [1]
 LDCM0367  CL1 HEK-293T C40(1.10); C51(1.17)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C40(1.90); C51(1.37)  LDD0966  [1]
 LDCM0370  CL101 HEK-293T C40(4.22)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C40(1.17)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C40(1.16)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C40(1.06)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C40(0.71)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C40(0.91)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C40(1.06)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C40(0.78)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C40(1.14)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C40(1.23); C51(1.26)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C40(0.81)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C40(0.99)  LDD0979  [1]
 LDCM0387  CL117 HEK-293T C51(0.80)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C51(1.04)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C51(0.65)  LDD0987  [1]
 LDCM0390  CL12 HEK-293T C40(2.23); C51(1.11)  LDD0988  [1]
 LDCM0391  CL120 HEK-293T C51(0.89)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C40(1.18); C51(1.76)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C40(1.00); C51(1.01)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C40(0.95); C51(1.15)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C40(1.05); C51(1.59)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C51(0.96)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C51(1.32)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C51(0.91)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C51(1.06)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C40(1.62); C51(1.35)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C40(1.07); C51(0.91)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C40(1.02); C51(0.92)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C51(0.91)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C51(1.13)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C51(1.19)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C51(1.17)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C40(0.96); C51(0.87)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C51(1.07)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C51(1.31)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C51(1.52)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C51(0.85)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C51(0.93)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C51(0.92)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C51(0.93)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C51(1.08)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C51(0.93)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C51(1.18)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C40(1.61); C51(1.10)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C51(1.33)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C51(0.61)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C51(0.69)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C51(0.64)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C51(0.80)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C51(0.83)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C51(0.73)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C51(0.61)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C51(1.10)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C40(1.16); C51(1.07)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C51(0.73)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C51(1.01)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C51(0.88)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C51(0.90)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C51(0.81)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C51(0.86)  LDD1033  [1]
 LDCM0440  CL5 HEK-293T C40(1.07); C51(1.21)  LDD1038  [1]
 LDCM0451  CL6 HEK-293T C40(1.65); C51(0.99)  LDD1049  [1]
 LDCM0462  CL7 HEK-293T C40(1.42); C51(0.93)  LDD1060  [1]
 LDCM0473  CL8 HEK-293T C40(1.09); C51(0.94)  LDD1071  [1]
 LDCM0484  CL9 HEK-293T C40(1.17); C51(1.19)  LDD1082  [1]
 LDCM0427  Fragment51 HEK-293T C51(0.76)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C40(3.72); C51(3.72)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C40(2.38); C51(2.38)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C40(4.55); C51(4.55)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264