Details of the Target

General Information of Target

Target ID LDTP14901
Target Name Zinc finger protein 699 (ZNF699)
Gene Name ZNF699
Gene ID 374879
Synonyms
Zinc finger protein 699; Hangover homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKIQLFFFILHFWVTILPAKKKYPEYGSLDLRRECRIGNGQCKNQCHENEIRIAYCIRPG
THCCLQQ
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q32M78
Ensemble ID
ENST00000308650.4
HGNC ID
HGNC:24750

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C533(2.31)  LDD0170  [1]
DBIA
 Probe Info  		C458(29.10)  LDD0209  [2]
IA-alkyne
 Probe Info  		C237(5.39)  LDD1703  [3]
HHS-465
 Probe Info  		K389(0.00); K392(0.00); Y391(0.00)  LDD2240  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C533(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C533(2.25)  LDD0171  [1]
 LDCM0214  AC1 HCT 116 C458(0.97)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C458(0.62)  LDD0532  [5]
 LDCM0226  AC11 HCT 116 C458(0.63)  LDD0543  [5]
 LDCM0230  AC113 HCT 116 C458(0.96)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C458(0.93)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C458(1.13)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C458(1.19)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C458(1.13)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C458(0.91)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C458(1.19)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C458(0.61)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C458(0.51)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C458(0.59)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C458(0.84)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C458(0.53)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C458(0.73)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C458(0.81)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C458(0.79)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C458(0.71)  LDD0562  [5]
 LDCM0259  AC14 HCT 116 C458(0.70)  LDD0576  [5]
 LDCM0270  AC15 HCT 116 C458(0.77)  LDD0587  [5]
 LDCM0277  AC18 HEK-293T C237(1.24)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C237(1.72)  LDD1517  [6]
 LDCM0279  AC2 HCT 116 C458(1.19)  LDD0596  [5]
 LDCM0281  AC21 HEK-293T C318(0.85); C195(1.05)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C318(1.05)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C318(1.09)  LDD1522  [6]
 LDCM0286  AC26 HEK-293T C237(1.09)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C237(0.90)  LDD1526  [6]
 LDCM0289  AC29 HEK-293T C318(1.04); C195(0.90)  LDD1528  [6]
 LDCM0290  AC3 HCT 116 C458(1.23)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C318(1.09)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C318(0.96)  LDD1531  [6]
 LDCM0295  AC34 HEK-293T C237(1.09)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C237(1.12)  LDD1535  [6]
 LDCM0298  AC37 HEK-293T C318(0.96); C195(1.06)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C318(0.84)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C318(0.98)  LDD1539  [6]
 LDCM0301  AC4 HCT 116 C458(1.28)  LDD0618  [5]
 LDCM0304  AC42 HEK-293T C237(1.23)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C237(1.14)  LDD1544  [6]
 LDCM0307  AC45 HEK-293T C318(1.08); C195(1.37)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C318(0.93)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C318(1.11)  LDD1548  [6]
 LDCM0312  AC5 HCT 116 C458(1.40)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C237(0.83)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C237(1.17)  LDD1553  [6]
 LDCM0316  AC53 HEK-293T C318(0.85); C195(1.20)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C318(0.83)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C318(0.98)  LDD1557  [6]
 LDCM0321  AC58 HEK-293T C237(0.94)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C237(1.16)  LDD1561  [6]
 LDCM0323  AC6 HCT 116 C458(1.15)  LDD0640  [5]
 LDCM0325  AC61 HEK-293T C318(1.31); C195(1.08)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C318(0.83)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C318(1.08)  LDD1566  [6]
 LDCM0334  AC7 HCT 116 C458(0.72)  LDD0651  [5]
 LDCM0345  AC8 HCT 116 C458(0.70)  LDD0662  [5]
 LDCM0349  AC83 HCT 116 C458(0.96)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C458(1.08)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C458(0.78)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C458(0.78)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C458(0.81)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C458(0.78)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C458(0.75)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C458(1.37)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C458(0.85)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C458(0.95)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C458(1.08)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C458(1.27)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C458(0.85)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C458(1.12)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C458(1.03)  LDD0681  [5]
 LDCM0248  AKOS034007472 HCT 116 C458(0.60)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C458(1.14)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C458(0.98)  LDD0592  [5]
 LDCM0367  CL1 HCT 116 C458(0.60)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C458(1.77)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C458(1.00)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C458(0.75)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C458(0.73)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C458(0.75)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C458(0.61)  LDD0690  [5]
 LDCM0375  CL106 HEK-293T C318(0.85)  LDD1579  [6]
 LDCM0377  CL108 HEK-293T C318(1.04)  LDD1581  [6]
 LDCM0379  CL11 HCT 116 C458(1.66)  LDD0696  [5]
 LDCM0380  CL110 HEK-293T C318(1.01)  LDD1584  [6]
 LDCM0382  CL112 HEK-293T C318(1.00)  LDD1586  [6]
 LDCM0384  CL114 HEK-293T C318(0.95)  LDD1588  [6]
 LDCM0386  CL116 HEK-293T C318(0.95)  LDD1590  [6]
 LDCM0388  CL118 HEK-293T C318(0.95)  LDD1592  [6]
 LDCM0390  CL12 HCT 116 C458(2.27)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C318(0.99)  LDD1595  [6]
 LDCM0393  CL122 HEK-293T C318(0.97)  LDD1597  [6]
 LDCM0395  CL124 HEK-293T C318(0.91)  LDD1599  [6]
 LDCM0397  CL126 HEK-293T C318(1.08)  LDD1601  [6]
 LDCM0399  CL128 HEK-293T C318(1.02)  LDD1603  [6]
 LDCM0400  CL13 HCT 116 C458(0.73)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C458(0.76)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C458(0.41)  LDD0719  [5]
 LDCM0403  CL16 HEK-293T C318(0.99)  LDD1607  [6]
 LDCM0405  CL18 HEK-293T C237(0.91)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C237(1.00)  LDD1610  [6]
 LDCM0407  CL2 HCT 116 C458(0.46)  LDD0724  [5]
 LDCM0409  CL21 HEK-293T C318(1.15); C195(0.84)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C318(0.89)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C318(1.09)  LDD1615  [6]
 LDCM0414  CL26 HEK-293T C318(0.90)  LDD1618  [6]
 LDCM0416  CL28 HEK-293T C318(0.97)  LDD1620  [6]
 LDCM0418  CL3 HCT 116 C458(0.78)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C237(0.95)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C237(1.17)  LDD1624  [6]
 LDCM0422  CL33 HEK-293T C318(0.72); C195(1.08)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C318(0.92)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C318(0.97)  LDD1628  [6]
 LDCM0429  CL4 HCT 116 C458(0.66)  LDD0746  [5]
 LDCM0430  CL40 HEK-293T C318(0.93)  LDD1634  [6]
 LDCM0432  CL42 HEK-293T C237(1.13)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C237(1.06)  LDD1637  [6]
 LDCM0435  CL45 HEK-293T C318(1.00); C195(0.95)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C318(0.81)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C318(0.98)  LDD1641  [6]
 LDCM0440  CL5 HCT 116 C458(0.46)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C318(1.08)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C318(1.04)  LDD1646  [6]
 LDCM0445  CL54 HEK-293T C237(0.93)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C237(1.03)  LDD1649  [6]
 LDCM0448  CL57 HEK-293T C318(1.12); C195(1.04)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C318(0.91)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C318(1.04)  LDD1653  [6]
 LDCM0451  CL6 HCT 116 C458(0.52)  LDD0768  [5]
 LDCM0454  CL62 HEK-293T C318(0.86)  LDD1657  [6]
 LDCM0456  CL64 HEK-293T C318(0.98)  LDD1659  [6]
 LDCM0458  CL66 HEK-293T C237(1.12)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C237(1.28)  LDD1662  [6]
 LDCM0461  CL69 HEK-293T C318(0.90); C195(0.91)  LDD1664  [6]
 LDCM0462  CL7 HCT 116 C458(1.04)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C318(1.01)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C318(1.10)  LDD1667  [6]
 LDCM0467  CL74 HEK-293T C318(0.86)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C318(1.01)  LDD1672  [6]
 LDCM0471  CL78 HEK-293T C237(1.31)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C237(0.95)  LDD1675  [6]
 LDCM0473  CL8 HCT 116 C458(0.87)  LDD0790  [5]
 LDCM0475  CL81 HEK-293T C318(0.87); C195(0.84)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C318(1.00)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C318(1.06)  LDD1680  [6]
 LDCM0480  CL86 HEK-293T C318(1.02)  LDD1683  [6]
 LDCM0482  CL88 HEK-293T C318(0.97)  LDD1685  [6]
 LDCM0484  CL9 HCT 116 C458(0.90)  LDD0801  [5]
 LDCM0485  CL90 HEK-293T C237(1.38)  LDD1688  [6]
 LDCM0486  CL91 HCT 116 C458(0.98)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C458(0.59)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C458(0.73)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C458(0.62)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C458(0.84)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C458(0.90)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C458(1.18)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C458(1.46)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C458(1.21)  LDD0811  [5]
 LDCM0427  Fragment51 HEK-293T C318(0.94)  LDD1631  [6]
 LDCM0022  KB02 T cell C237(5.39)  LDD1703  [3]
 LDCM0023  KB03 Jurkat C458(29.10)  LDD0209  [2]
 LDCM0024  KB05 NCI-H1975 C458(2.06)  LDD3352  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Sarcoplasmic reticulum histidine-rich calcium-binding protein (HRC) HRC family P23327
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Serine/arginine repetitive matrix protein 4 (SRRM4) NSR100 family A7MD48

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840