Details of the Target

General Information of Target

Target ID LDTP14779
Target Name UBX domain-containing protein 2A (UBXN2A)
Gene Name UBXN2A
Gene ID 165324
Synonyms
UBXD4; UBX domain-containing protein 2A; UBX domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADKPDMGEIASFDKAKLKKTETQEKNTLPTKETIEQEKRSEIS
Target Bioclass
Other
Function
Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons. Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation. Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9. Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway.
Uniprot ID
P68543
Ensemble ID
ENST00000309033.5
HGNC ID
HGNC:27265

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.F202L .
KYSE410 SNV: p.G96A .
NALM6 Deletion: p.K95RfsTer46 .
RBE SNV: p.D62G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C51(3.04)  LDD3342  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C123(0.94); C51(1.07)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C123(0.96); C51(1.07)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C123(0.98)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C51(1.17)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C51(0.96)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C123(0.95); C51(1.08)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C123(0.91); C51(0.95)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C123(0.97); C51(1.10)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C123(1.04)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C123(1.07); C51(0.91)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C51(1.03)  LDD1519  [2]
 LDCM0282  AC22 HEK-293T C51(0.90)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C123(0.98); C51(1.01)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C123(0.90); C51(0.96)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C123(0.96); C51(1.02)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C123(0.97)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C51(1.08)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C123(0.98)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C51(0.96)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C123(0.97); C51(1.17)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C123(1.03); C51(1.03)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C123(0.99); C51(0.96)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C123(0.94)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C51(1.04)  LDD1536  [2]
 LDCM0299  AC38 HEK-293T C51(0.99)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C123(1.00); C51(1.06)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C51(1.13)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C123(0.94); C51(1.05)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C123(0.98); C51(1.05)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C123(1.00)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C51(1.17)  LDD1545  [2]
 LDCM0308  AC46 HEK-293T C51(0.99)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C123(0.96); C51(0.94)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C123(0.95); C51(0.93)  LDD1550  [2]
 LDCM0313  AC50 HEK-293T C123(1.01); C51(1.01)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C123(1.00)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C51(1.13)  LDD1554  [2]
 LDCM0317  AC54 HEK-293T C51(1.05)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C123(0.94); C51(1.12)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C123(0.95); C51(1.09)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C123(0.99); C51(0.96)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C123(0.98)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C51(0.89)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C51(1.09)  LDD1563  [2]
 LDCM0326  AC62 HEK-293T C51(1.03)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C123(0.95); C51(0.99)  LDD1566  [2]
 LDCM0332  AC68 PaTu 8988t C51(0.98)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C51(1.15)  LDD1212  [3]
 LDCM0334  AC7 HEK-293T C123(0.98); C51(1.02)  LDD1568  [2]
 LDCM0335  AC70 PaTu 8988t C51(1.07)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C51(1.07)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C51(1.23)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C51(1.14)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C51(0.94)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C51(1.49)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C51(0.95)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C51(0.74)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C51(0.79)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C51(1.05)  LDD1223  [3]
 LDCM0346  AC80 PaTu 8988t C51(0.92)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C51(1.25)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C51(0.83)  LDD1227  [3]
 LDCM0349  AC83 PaTu 8988t C51(0.69)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C51(1.07)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C51(0.78)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C51(0.73)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C51(0.77)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C51(0.88)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C51(0.86)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C51(0.85)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C51(0.77)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C51(0.72)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C51(0.74)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C51(0.82)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C51(0.78)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C51(0.91)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C51(0.72)  LDD1243  [3]
 LDCM0356  AKOS034007680 HEK-293T C123(0.96); C51(1.06)  LDD1570  [2]
 LDCM0367  CL1 PaTu 8988t C51(1.53)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C51(1.41)  LDD1247  [3]
 LDCM0369  CL100 HEK-293T C123(0.95); C51(0.60)  LDD1573  [2]
 LDCM0371  CL102 HEK-293T C51(1.05)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C51(0.92)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C123(1.05); C51(0.99)  LDD1577  [2]
 LDCM0375  CL106 HEK-293T C51(1.01)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C51(1.18)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C123(0.96); C51(1.08)  LDD1581  [2]
 LDCM0379  CL11 PaTu 8988t C51(1.49)  LDD1258  [3]
 LDCM0380  CL110 HEK-293T C51(0.97)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C51(0.87)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C123(0.93); C51(1.02)  LDD1586  [2]
 LDCM0384  CL114 HEK-293T C51(0.96)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C51(0.79)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C123(1.06); C51(0.99)  LDD1590  [2]
 LDCM0388  CL118 HEK-293T C51(1.14)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C51(0.98)  LDD1593  [2]
 LDCM0390  CL12 PaTu 8988t C51(1.63)  LDD1269  [3]
 LDCM0391  CL120 HEK-293T C123(1.04); C51(1.10)  LDD1595  [2]
 LDCM0393  CL122 HEK-293T C51(1.13)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C51(0.81)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C123(0.97); C51(1.00)  LDD1599  [2]
 LDCM0397  CL126 HEK-293T C51(1.09)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C51(1.04)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C123(1.03); C51(0.96)  LDD1603  [2]
 LDCM0400  CL13 PaTu 8988t C51(1.27)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C51(1.68)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C51(1.95)  LDD1281  [3]
 LDCM0403  CL16 HEK-293T C123(0.94); C51(0.98)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C123(0.90); C51(1.02)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C123(1.08); C51(0.99)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C123(1.14)  LDD1610  [2]
 LDCM0407  CL2 PaTu 8988t C51(0.96)  LDD1286  [3]
 LDCM0408  CL20 HEK-293T C51(1.09)  LDD1612  [2]
 LDCM0410  CL22 HEK-293T C51(1.18)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C123(1.47); C51(1.10)  LDD1615  [2]
 LDCM0414  CL26 HEK-293T C51(1.00)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C51(0.89)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C123(1.04); C51(1.04)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C123(0.93); C51(0.96)  LDD1621  [2]
 LDCM0418  CL3 PaTu 8988t C51(1.80)  LDD1297  [3]
 LDCM0419  CL30 HEK-293T C123(1.09); C51(1.08)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C123(1.11)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C51(1.19)  LDD1625  [2]
 LDCM0423  CL34 HEK-293T C51(1.31)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C123(1.55); C51(1.14)  LDD1628  [2]
 LDCM0428  CL39 HEK-293T C51(0.93)  LDD1632  [2]
 LDCM0429  CL4 PaTu 8988t C51(1.22)  LDD1308  [3]
 LDCM0430  CL40 HEK-293T C123(0.98); C51(1.00)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C123(0.95); C51(1.04)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C123(1.17); C51(1.04)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C123(1.20)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C51(1.08)  LDD1638  [2]
 LDCM0436  CL46 PaTu 8988t C51(1.02)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C51(1.07)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C51(1.77)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C51(1.74)  LDD1318  [3]
 LDCM0440  CL5 PaTu 8988t C51(2.26)  LDD1319  [3]
 LDCM0441  CL50 PaTu 8988t C51(1.74)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C51(1.88)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C51(1.67)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C51(3.33)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C51(1.23)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C51(1.62)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C51(1.41)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C51(1.92)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C51(1.75)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C51(1.55)  LDD1329  [3]
 LDCM0451  CL6 PaTu 8988t C51(1.67)  LDD1330  [3]
 LDCM0452  CL60 PaTu 8988t C51(1.46)  LDD1331  [3]
 LDCM0454  CL62 HEK-293T C51(1.04)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C51(0.98)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C123(0.93); C51(0.97)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C123(1.05); C51(1.10)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C123(1.11); C51(1.01)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C123(1.08)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C51(1.07)  LDD1663  [2]
 LDCM0462  CL7 PaTu 8988t C51(1.17)  LDD1341  [3]
 LDCM0463  CL70 HEK-293T C51(1.25)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C123(1.32); C51(1.03)  LDD1667  [2]
 LDCM0467  CL74 HEK-293T C51(0.92)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C123(1.12); C51(1.04)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C123(0.85); C51(0.91)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C123(1.05); C51(0.95)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C123(1.10)  LDD1675  [2]
 LDCM0473  CL8 PaTu 8988t C51(1.38)  LDD1352  [3]
 LDCM0474  CL80 HEK-293T C51(1.06)  LDD1677  [2]
 LDCM0476  CL82 HEK-293T C51(0.97)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C123(1.25); C51(1.15)  LDD1680  [2]
 LDCM0480  CL86 HEK-293T C51(0.97)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C51(0.87)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C123(1.06); C51(0.97)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C123(0.98); C51(0.95)  LDD1686  [2]
 LDCM0484  CL9 PaTu 8988t C51(1.47)  LDD1363  [3]
 LDCM0485  CL90 HEK-293T C123(0.91); C51(1.05)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C123(1.12)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C51(1.09)  LDD1690  [2]
 LDCM0489  CL94 HEK-293T C51(1.14)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C123(1.04); C51(1.08)  LDD1693  [2]
 LDCM0493  CL98 HEK-293T C51(0.99)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C51(0.71)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C51(0.79)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C51(0.88)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C51(1.09)  LDD1631  [2]
 LDCM0022  KB02 A-375 C51(1.44)  LDD2255  [1]
 LDCM0023  KB03 A-375 C51(1.84)  LDD2672  [1]
 LDCM0024  KB05 NCI-H1155 C51(3.04)  LDD3342  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DPY30 domain-containing protein 2 (DYDC2) Dpy-30 family Q96IM9
UBX domain-containing protein 6 (UBXN6) . Q9BZV1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.