Details of the Target

General Information of Target

Target ID LDTP14441
Target Name Zinc finger protein 536 (ZNF536)
Gene Name ZNF536
Gene ID 9745
Synonyms
KIAA0390; Zinc finger protein 536
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS
AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV
AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS
AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS
AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP
VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD
STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ
EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP
SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV
LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE
DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL
QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD
EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS
KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR
PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL
TM
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription. Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'.
Uniprot ID
O15090
Ensemble ID
ENST00000355537.4
HGNC ID
HGNC:29025

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1041(1.03)  LDD1510  [1]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [2]
HHS-465
 Probe Info  		K777(0.00); K780(0.00); Y779(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C1041(1.03)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C1041(0.94)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C1041(0.71)  LDD1513  [1]
 LDCM0280  AC20 HEK-293T C1041(1.08)  LDD1519  [1]
 LDCM0282  AC22 HEK-293T C1041(0.75)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C1041(0.71)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C1041(0.96)  LDD1523  [1]
 LDCM0288  AC28 HEK-293T C1041(0.95)  LDD1527  [1]
 LDCM0291  AC30 HEK-293T C1041(1.07)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C1041(0.86)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C1041(1.05)  LDD1532  [1]
 LDCM0297  AC36 HEK-293T C1041(0.96)  LDD1536  [1]
 LDCM0299  AC38 HEK-293T C1041(0.95)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C1041(0.89)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C1041(1.00)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C1041(0.98)  LDD1541  [1]
 LDCM0306  AC44 HEK-293T C1041(0.98)  LDD1545  [1]
 LDCM0308  AC46 HEK-293T C1041(0.98)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C1041(0.88)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C1041(1.03)  LDD1549  [1]
 LDCM0315  AC52 HEK-293T C1041(0.95)  LDD1554  [1]
 LDCM0317  AC54 HEK-293T C1041(1.05)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C1041(0.92)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C1041(0.95)  LDD1558  [1]
 LDCM0323  AC6 HEK-293T C1041(1.04)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C1041(1.14)  LDD1563  [1]
 LDCM0326  AC62 HEK-293T C1041(1.17)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C1041(1.07)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C1041(1.12)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C1041(0.83)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C1041(0.96)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C1041(0.81)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C1041(0.64)  LDD1572  [1]
 LDCM0379  CL11 HEK-293T C1041(0.52)  LDD1583  [1]
 LDCM0390  CL12 HEK-293T C1041(0.62)  LDD1594  [1]
 LDCM0408  CL20 HEK-293T C1041(0.73)  LDD1612  [1]
 LDCM0410  CL22 HEK-293T C1041(0.60)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C1041(0.52)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C1041(0.68)  LDD1616  [1]
 LDCM0421  CL32 HEK-293T C1041(0.70)  LDD1625  [1]
 LDCM0423  CL34 HEK-293T C1041(0.63)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C1041(0.55)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C1041(0.68)  LDD1629  [1]
 LDCM0434  CL44 HEK-293T C1041(0.79)  LDD1638  [1]
 LDCM0436  CL46 HEK-293T C1041(0.65)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C1041(0.57)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C1041(0.66)  LDD1642  [1]
 LDCM0447  CL56 HEK-293T C1041(0.84)  LDD1650  [1]
 LDCM0449  CL58 HEK-293T C1041(0.62)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C1041(0.50)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C1041(0.64)  LDD1655  [1]
 LDCM0460  CL68 HEK-293T C1041(0.72)  LDD1663  [1]
 LDCM0463  CL70 HEK-293T C1041(0.68)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C1041(0.64)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C1041(0.71)  LDD1668  [1]
 LDCM0473  CL8 HEK-293T C1041(0.67)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C1041(0.88)  LDD1677  [1]
 LDCM0476  CL82 HEK-293T C1041(0.68)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C1041(0.65)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C1041(0.71)  LDD1681  [1]
 LDCM0487  CL92 HEK-293T C1041(0.90)  LDD1690  [1]
 LDCM0489  CL94 HEK-293T C1041(0.84)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C1041(0.71)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C1041(0.83)  LDD1694  [1]
 LDCM0022  KB02 A375.S2 C1105(1.31)  LDD2256  [4]
 LDCM0023  KB03 CHL-1 C1105(4.13)  LDD2718  [4]
 LDCM0024  KB05 CHL-1 C1105(4.14)  LDD3135  [4]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840