Details of the Target

General Information of Target

Target ID LDTP14285
Target Name Stonin-1 (STON1)
Gene Name STON1
Gene ID 11037
Synonyms
SALF; SBLF; STN1; Stonin-1; Stoned B-like factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDD
PHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGI
FHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGL
TITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQ
EVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISE
EWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCW
TVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYI
IGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTS
EFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPY
LVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDA
DPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL
Target Bioclass
Other
Family
Stoned B family
Subcellular location
Cytoplasm
Function May be involved in the endocytic machinery.
Uniprot ID
Q9Y6Q2
Ensemble ID
ENST00000404752.6
HGNC ID
HGNC:17003

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.Q174Ter .
HCT15 Deletion: p.K478RfsTer14 .
L428 SNV: p.R563S; p.M597I .
NCIH1048 SNV: p.T584I .
NCIH1793 SNV: p.C650F .
PC9 SNV: p.P575L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C707(1.43)  LDD3333  [1]
IPM
 Probe Info  		C180(0.00); C224(0.00)  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C180(0.96)  LDD1507  [3]
 LDCM0226  AC11 HEK-293T C180(0.96)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C681(1.22)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C681(0.91); C707(1.00)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C180(0.94)  LDD1515  [3]
 LDCM0278  AC19 HEK-293T C180(1.20)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C681(1.05)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C707(1.10); C224(0.99)  LDD1520  [3]
 LDCM0283  AC23 HEK-293T C681(0.86); C707(0.96)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C707(0.92)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C180(0.82)  LDD1524  [3]
 LDCM0287  AC27 HEK-293T C180(0.83)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C681(1.20)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C707(0.96); C224(0.93)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C180(1.07)  LDD1529  [3]
 LDCM0292  AC31 HEK-293T C681(1.03); C707(0.99)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C707(0.87)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C180(1.08)  LDD1533  [3]
 LDCM0296  AC35 HEK-293T C180(0.97)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C681(1.15)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C707(0.99); C224(0.92)  LDD1537  [3]
 LDCM0300  AC39 HEK-293T C681(1.00); C707(1.09)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C681(0.98)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C707(0.92)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C180(0.90)  LDD1542  [3]
 LDCM0305  AC43 HEK-293T C180(1.00)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C681(1.05)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C707(0.91); C224(1.08)  LDD1546  [3]
 LDCM0309  AC47 HEK-293T C681(1.07); C707(0.92)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C707(1.01)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C180(0.98)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C707(1.10); C224(0.85)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C180(0.88)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C681(1.14)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C707(1.13); C224(0.96)  LDD1555  [3]
 LDCM0318  AC55 HEK-293T C681(1.00); C707(0.97)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C707(1.02)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C180(1.04)  LDD1559  [3]
 LDCM0322  AC59 HEK-293T C180(1.01)  LDD1561  [3]
 LDCM0324  AC60 HEK-293T C681(1.26)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C707(1.07); C224(0.93)  LDD1564  [3]
 LDCM0327  AC63 HEK-293T C681(1.03); C707(1.07)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C707(1.12)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C681(1.07); C707(1.00)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C707(1.04)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C707(0.94); C224(0.96)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C180(1.06)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C707(1.02)  LDD1514  [3]
 LDCM0369  CL100 HEK-293T C180(0.90)  LDD1573  [3]
 LDCM0373  CL104 HEK-293T C180(1.01)  LDD1577  [3]
 LDCM0377  CL108 HEK-293T C180(0.86)  LDD1581  [3]
 LDCM0379  CL11 HEK-293T C681(1.00); C707(1.09)  LDD1583  [3]
 LDCM0382  CL112 HEK-293T C180(0.80)  LDD1586  [3]
 LDCM0386  CL116 HEK-293T C180(0.95)  LDD1590  [3]
 LDCM0390  CL12 HEK-293T C707(1.29)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C180(0.91)  LDD1595  [3]
 LDCM0395  CL124 HEK-293T C180(1.01)  LDD1599  [3]
 LDCM0399  CL128 HEK-293T C180(0.88)  LDD1603  [3]
 LDCM0403  CL16 HEK-293T C180(0.91)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C180(0.99)  LDD1608  [3]
 LDCM0406  CL19 HEK-293T C180(0.88)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C681(1.17)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C707(0.97); C224(1.15)  LDD1613  [3]
 LDCM0411  CL23 HEK-293T C681(1.14); C707(1.19)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C707(0.96)  LDD1616  [3]
 LDCM0416  CL28 HEK-293T C180(1.04)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C180(0.98)  LDD1621  [3]
 LDCM0420  CL31 HEK-293T C180(1.11)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C681(1.12)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C707(1.03); C224(1.07)  LDD1626  [3]
 LDCM0424  CL35 HEK-293T C681(1.29); C707(1.00)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C707(0.91)  LDD1629  [3]
 LDCM0429  CL4 HEK-293T C180(0.87)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C180(0.96)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C180(0.87)  LDD1635  [3]
 LDCM0433  CL43 HEK-293T C180(1.01)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C681(1.11)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C707(1.02); C224(1.21)  LDD1639  [3]
 LDCM0437  CL47 HEK-293T C681(1.03); C707(1.00)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C707(0.92)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C180(0.96)  LDD1644  [3]
 LDCM0443  CL52 HEK-293T C180(0.91)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C180(1.08)  LDD1647  [3]
 LDCM0446  CL55 HEK-293T C180(0.87)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C681(1.05)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C707(0.97); C224(0.93)  LDD1651  [3]
 LDCM0450  CL59 HEK-293T C681(1.16); C707(0.94)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C707(1.07)  LDD1655  [3]
 LDCM0456  CL64 HEK-293T C180(0.78)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C180(0.94)  LDD1660  [3]
 LDCM0459  CL67 HEK-293T C180(0.88)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C681(1.34)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C707(1.13); C224(1.11)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C180(0.72)  LDD1665  [3]
 LDCM0464  CL71 HEK-293T C681(1.23); C707(0.95)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C707(1.00)  LDD1668  [3]
 LDCM0469  CL76 HEK-293T C180(1.02)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C180(0.87)  LDD1673  [3]
 LDCM0472  CL79 HEK-293T C180(0.86)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C681(1.18)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C681(1.13)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C707(0.96); C224(1.09)  LDD1678  [3]
 LDCM0477  CL83 HEK-293T C681(1.15); C707(0.95)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C707(0.96)  LDD1681  [3]
 LDCM0482  CL88 HEK-293T C180(0.90)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C180(1.00)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C707(0.92); C224(1.07)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C180(0.96)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C681(1.16)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C707(0.95); C224(0.99)  LDD1691  [3]
 LDCM0490  CL95 HEK-293T C681(0.89); C707(1.15)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C707(1.09)  LDD1694  [3]
 LDCM0022  KB02 A-172 C707(1.50)  LDD2251  [1]
 LDCM0023  KB03 A-375 C707(1.48)  LDD2672  [1]
 LDCM0024  KB05 MOLM-13 C707(1.43)  LDD3333  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402