Details of the Target

General Information of Target

Target ID LDTP14162
Target Name Tumor necrosis factor receptor superfamily member 18 (TNFRSF18)
Gene Name TNFRSF18
Gene ID 8784
Synonyms
AITR; GITR; Tumor necrosis factor receptor superfamily member 18; Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein; CD antigen CD357
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEGETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPP
DVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINH
ASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQY
TSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Subcellular location
Secreted; Cell membrane
Function
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
TTD ID
T15344
Uniprot ID
Q9Y5U5
DrugMap ID
TTG6LA7
Ensemble ID
ENST00000328596.10
HGNC ID
HGNC:11914
ChEMBL ID
CHEMBL3712995

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HELA SNV: p.A175V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C218(0.68)  LDD0602  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0285  AC25 HCT 116 C218(0.68)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C218(1.30)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C218(0.83)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C218(1.18)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C218(0.60)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C218(0.86)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C218(1.11)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C218(0.86)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C218(0.79)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C218(1.11)  LDD0612  [1]
 LDCM0332  AC68 HCT 116 C218(1.39)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C218(0.96)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C218(1.09)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C218(0.76)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C218(0.98)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C218(0.76)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C218(1.29)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C218(1.37)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C218(0.99)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C218(1.13)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C218(0.65)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C218(1.01)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C218(0.87)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C218(1.38)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C218(1.08)  LDD0665  [1]
 LDCM0382  CL112 HCT 116 C218(0.60)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C218(0.86)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C218(0.93)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C218(0.68)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C218(0.89)  LDD0703  [1]
 LDCM0403  CL16 HCT 116 C218(0.90)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C218(0.84)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C218(1.02)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C218(1.37)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C218(1.11)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C218(1.48)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C218(2.08)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C218(1.15)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C218(1.11)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C218(1.36)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C218(0.97)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C218(0.93)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C218(1.04)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C218(0.94)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C218(0.76)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C218(1.04)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C218(1.29)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C218(1.09)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C218(1.16)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C218(1.22)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C218(1.53)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C218(1.25)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C218(0.84)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C218(1.30)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C218(0.94)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C218(1.05)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C218(1.25)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C218(0.99)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C218(1.26)  LDD0752  [1]
 LDCM0453  CL61 HCT 116 C218(1.06)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C218(0.82)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C218(1.09)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C218(1.25)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C218(1.28)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C218(1.34)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C218(1.71)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C218(1.07)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C218(1.04)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C218(1.16)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C218(0.98)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C218(1.03)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C218(0.95)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C218(1.12)  LDD0784  [1]
 LDCM0468  Fragment33 HCT 116 C218(1.22)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C218(1.09)  LDD0744  [1]
 LDCM0022  KB02 HCC1187 C218(1.51)  LDD2337  [2]
 LDCM0023  KB03 HCC70 C218(1.72)  LDD2762  [2]
 LDCM0024  KB05 HCC1187 C218(1.90)  LDD3171  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) Tumor necrosis factor family Q9UNG2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquilin-2 (UBQLN2) . Q9UHD9

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Incagn01876 Antibody DOI7H2
Trx-518 Antibody D0J1MO
Incagn1876 . D06CJN
Phase 1
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amg 228 Antibody DG17UJ
Asp1951 Antibody DYSI03
Mk-4166 Antibody D0Y2XZ
Regn6569 Antibody D8CFX3
Trx518 Antibody DJ6NE2

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840