Details of the Target

General Information of Target

Target ID LDTP14144
Target Name Transcription factor MafB (MAFB)
Gene Name MAFB
Gene ID 9935
Synonyms
KRML; Transcription factor MafB; Maf-B; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGVGEPGPREGPAQPGAPLPTFCWEQIRAHDQPGDKWLVIERRVYDISRWAQRHPGGSR
LIGHHGAEDATDAFRAFHQDLNFVRKFLQPLLIGELAPEEPSQDGPLNAQLVEDFRALHQ
AAEDMKLFDASPTFFAFLLGHILAMEVLAWLLIYLLGPGWVPSALAAFILAISQAQSWCL
QHDLGHASIFKKSWWNHVAQKFVMGQLKGFSAHWWNFRHFQHHAKPNIFHKDPDVTVAPV
FLLGESSVEYGKKKRRYLPYNQQHLYFFLIGPPLLTLVNFEVENLAYMLVCMQWADLLWA
ASFYARFFLSYLPFYGVPGVLLFFVAVRVLESHWFVWITQMNHIPKEIGHEKHRDWVSSQ
LAATCNVEPSLFTNWFSGHLNFQIEHHLFPRMPRHNYSRVAPLVKSLCAKHGLSYEVKPF
LTALVDIVRSLKKSGDIWLDAYLHQ
Target Bioclass
Transcription factor
Family
BZIP family, Maf subfamily
Subcellular location
Nucleus
Function
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain.
Uniprot ID
Q9Y5Q3
Ensemble ID
ENST00000373313.3
HGNC ID
HGNC:6408

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C46(2.04)  LDD3410  [1]
Phosphinate-6
 Probe Info  		C46(0.00); C255(0.00)  LDD0018  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C46(1.28)  LDD1507  [3]
 LDCM0237  AC12 HEK-293T C46(0.98)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C46(1.08); C255(1.17)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C255(1.15)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C46(1.03)  LDD1515  [3]
 LDCM0280  AC20 HEK-293T C46(1.02)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C255(0.93)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C46(1.13); C255(1.09)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C255(1.11)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C46(0.95); C255(1.23)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C46(1.09)  LDD1524  [3]
 LDCM0288  AC28 HEK-293T C46(1.11)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C255(1.06)  LDD1528  [3]
 LDCM0291  AC30 HEK-293T C46(1.03); C255(0.96)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C255(1.09)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C46(0.98); C255(1.19)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C46(1.16)  LDD1533  [3]
 LDCM0297  AC36 HEK-293T C46(0.96)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C255(1.09)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C46(1.11); C255(1.19)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C255(1.13)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C46(1.05)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C46(1.09); C255(1.06)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C46(1.10)  LDD1542  [3]
 LDCM0306  AC44 HEK-293T C46(1.03)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C255(0.98)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C46(1.01); C255(1.16)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C255(1.23)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C46(0.97); C255(1.16)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C46(1.13)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C255(1.11)  LDD1551  [3]
 LDCM0315  AC52 HEK-293T C46(1.04)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C255(1.05)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C46(1.03); C255(1.09)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C255(1.26)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C46(0.98); C255(1.12)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C46(1.13)  LDD1559  [3]
 LDCM0323  AC6 HEK-293T C46(1.10); C255(1.03)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C46(0.89)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C255(1.16)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C46(1.05); C255(1.07)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C255(1.13)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C46(1.04); C255(1.15)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C255(1.09)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C46(1.08); C255(1.07)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C255(1.02)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C46(1.17)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C46(1.11); C255(1.05)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C46(1.21)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C46(1.08); C255(1.00)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C46(1.20)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C46(1.07)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C46(1.05)  LDD1576  [3]
 LDCM0374  CL105 HEK-293T C46(1.09)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C46(1.04)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C46(0.93)  LDD1580  [3]
 LDCM0378  CL109 HEK-293T C46(1.15)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C255(1.04)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C46(1.06)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C46(0.96)  LDD1585  [3]
 LDCM0383  CL113 HEK-293T C46(1.10)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C46(0.99)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C46(1.08)  LDD1589  [3]
 LDCM0387  CL117 HEK-293T C46(1.14)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C46(1.13)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C46(1.08)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C46(1.10); C255(1.33)  LDD1594  [3]
 LDCM0392  CL121 HEK-293T C46(1.08)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C46(1.11)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C46(0.98)  LDD1598  [3]
 LDCM0396  CL125 HEK-293T C46(1.06)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C46(1.07)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C46(1.05)  LDD1602  [3]
 LDCM0400  CL13 HEK-293T C46(1.22)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C46(1.07)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C46(1.00)  LDD1606  [3]
 LDCM0404  CL17 HEK-293T C46(1.18)  LDD1608  [3]
 LDCM0407  CL2 HEK-293T C46(1.05)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C46(1.03)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C255(1.10)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C46(1.21); C255(1.07)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C255(1.15)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C46(0.89); C255(0.97)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C46(1.01)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C46(1.02)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C46(1.01)  LDD1619  [3]
 LDCM0417  CL29 HEK-293T C46(1.06)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C46(0.94)  LDD1622  [3]
 LDCM0421  CL32 HEK-293T C46(0.92)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C255(0.93)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C46(0.97); C255(1.06)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C255(1.28)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C46(0.97); C255(1.23)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C46(1.09)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C46(1.03)  LDD1632  [3]
 LDCM0431  CL41 HEK-293T C46(1.16)  LDD1635  [3]
 LDCM0434  CL44 HEK-293T C46(0.93)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C255(1.03)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C46(1.05); C255(1.08)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C255(1.00)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C46(0.97); C255(1.00)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C46(1.09)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C46(1.03)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C46(1.17)  LDD1645  [3]
 LDCM0444  CL53 HEK-293T C46(1.16)  LDD1647  [3]
 LDCM0447  CL56 HEK-293T C46(0.93)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C255(1.11)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C46(1.17); C255(1.19)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C255(1.29)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C46(1.14); C255(1.33)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C46(1.08)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C46(1.16)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C46(1.10)  LDD1658  [3]
 LDCM0457  CL65 HEK-293T C46(1.00)  LDD1660  [3]
 LDCM0460  CL68 HEK-293T C46(1.04)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C255(1.02)  LDD1664  [3]
 LDCM0463  CL70 HEK-293T C46(1.08); C255(1.10)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C255(1.37)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C46(1.17); C255(1.15)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C46(1.24)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C46(1.09)  LDD1670  [3]
 LDCM0470  CL77 HEK-293T C46(1.16)  LDD1673  [3]
 LDCM0473  CL8 HEK-293T C46(0.85)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C46(1.01)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C255(1.13)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C46(1.18); C255(1.15)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C255(1.19)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C46(0.98); C255(1.22)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C46(0.99)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C46(1.09)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C46(1.07)  LDD1684  [3]
 LDCM0483  CL89 HEK-293T C46(1.10)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C255(0.92)  LDD1687  [3]
 LDCM0487  CL92 HEK-293T C46(0.89)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C255(1.05)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C46(1.08); C255(1.12)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C255(1.21)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C46(1.01); C255(1.24)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C46(0.96)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C46(1.08)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C46(1.09)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C46(1.21)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C46(1.07)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C46(1.03)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C255(1.00)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C255(1.03)  LDD1497  [3]
 LDCM0024  KB05 RPMI-7951 C46(2.04)  LDD3410  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription regulator protein BACH1 (BACH1) BZIP family O14867
Protein c-Fos (FOS) BZIP family P01100
Transcription factor Maf (MAF) BZIP family O75444
Transcription factor MafB (MAFB) BZIP family Q9Y5Q3
Interferon regulatory factor 3 (IRF3) IRF family Q14653
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402