Details of the Target

General Information of Target

Target ID LDTP13872
Target Name Ninein-like protein (NINL)
Gene Name NINL
Gene ID 22981
Synonyms
KIAA0980; NLP; Ninein-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYLSRFLSIHALWVTVSSVMQPYPLVWGHYDLCKTQIYTEEGKVWDYMACQPESTDMTKY
LKVKLDPPDITCGDPPETFCAMGNPYMCNNECDASTPELAHPPELMFDFEGRHPSTFWQS
ATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYAT
DCLDAFHMDPKSVKDLSQHTVLEIICTEEYSTGYTTNSKIIHFEIKDRFAFFAGPRLRNM
ASLYGQLDTTKKLRDFFTVTDLRIRLLRPAVGEIFVDELHLARYFYAISDIKVRGRCKCN
LHATVCVYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISS
IGNCECFGHSNRCSYIDLLNTVICVSCKHNTRGQHCELCRLGYFRNASAQLDDENVCIEC
YCNPLGSIHDRCNGSGFCECKTGTTGPKCDECLPGNSWHYGCQPNVCDNELLHCQNGGTC
HNNVRCLCPAAYTGILCEKLRCEEAGSCGSDSGQGAPPHGSPALLLLTTLLGTASPLVF
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells. May play a role in ovarian carcinogenesis.
Uniprot ID
Q9Y2I6
Ensemble ID
ENST00000278886.11
HGNC ID
HGNC:29163

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G229W .
HT115 SNV: p.R1366C .
KMCH1 SNV: p.D865Y .
LS513 SNV: p.G232Ter .
MCC26 SNV: p.R1366C .
MEC1 SNV: p.K1128M .
MELJUSO SNV: p.A965G .
MEWO SNV: p.Q1244P .
MFE296 SNV: p.T122I .
MFE319 SNV: p.A134V; p.Q788Ter .
MOLT4 SNV: p.R667C .
MSTO211H SNV: p.L270P .
NCIH1993 SNV: p.L262V .
NCIH2172 SNV: p.W986C; p.R1000L .
NCIH2286 SNV: p.Q998H .
SG231 SNV: p.R880S .
SKMEL2 SNV: p.H727R .
SW1271 SNV: p.R404M .
TE11 SNV: p.V1295G .
TE4 SNV: p.R458L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C853(0.99)  LDD1509  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C853(0.99)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C853(0.79)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C853(0.83)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C853(0.89)  LDD1513  [1]
 LDCM0278  AC19 HEK-293T C853(1.33)  LDD1517  [1]
 LDCM0280  AC20 HEK-293T C853(0.92)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C853(0.86)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C853(0.86)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C853(0.74)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C853(1.44); C790(1.00)  LDD1523  [1]
 LDCM0287  AC27 HEK-293T C853(1.04)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C853(1.33)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C853(0.89)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C853(1.26)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C853(0.91)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C853(0.76)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C853(0.74); C790(0.96)  LDD1532  [1]
 LDCM0296  AC35 HEK-293T C853(0.98)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C853(0.89)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C853(0.85)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C853(0.96)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C853(1.18)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C853(1.13)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C853(0.90); C790(0.94)  LDD1541  [1]
 LDCM0305  AC43 HEK-293T C853(0.97)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C853(1.00)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C853(1.15)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C853(0.94)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C853(0.89)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C853(1.52); C790(1.07)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C853(0.80)  LDD1551  [1]
 LDCM0314  AC51 HEK-293T C853(1.38)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C853(1.13)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C853(0.93)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C853(0.83)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C853(1.08)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C853(1.27); C790(1.08)  LDD1558  [1]
 LDCM0322  AC59 HEK-293T C853(1.14)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C853(0.95)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C853(1.13)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C853(1.38)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C853(1.08)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C853(0.94)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C853(1.72); C790(1.00)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C853(1.09)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C853(1.38); C790(0.98)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C853(0.78)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C853(1.33); C790(1.05)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C853(0.63)  LDD1572  [1]
 LDCM0379  CL11 HEK-293T C853(0.56)  LDD1583  [1]
 LDCM0390  CL12 HEK-293T C853(0.62); C790(1.14)  LDD1594  [1]
 LDCM0406  CL19 HEK-293T C853(0.87)  LDD1610  [1]
 LDCM0408  CL20 HEK-293T C853(0.70)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C853(0.66)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C853(0.47)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C853(0.47)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C853(0.68); C790(1.17)  LDD1616  [1]
 LDCM0420  CL31 HEK-293T C853(0.69)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C853(0.53)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C853(0.63)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C853(0.51)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C853(0.55)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C853(0.66); C790(1.26)  LDD1629  [1]
 LDCM0433  CL43 HEK-293T C853(0.74)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C853(0.69)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C853(0.65)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C853(0.52)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C853(0.50)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C853(0.66); C790(1.27)  LDD1642  [1]
 LDCM0446  CL55 HEK-293T C853(0.89)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C853(0.62)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C853(0.56)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C853(0.48)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C853(0.54)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C853(0.57); C790(1.14)  LDD1655  [1]
 LDCM0459  CL67 HEK-293T C853(0.90)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C853(0.66)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C853(0.63)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C853(0.82)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C853(0.54)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C853(0.56)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C853(0.66); C790(1.19)  LDD1668  [1]
 LDCM0472  CL79 HEK-293T C853(0.76)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C853(0.64)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C853(0.97)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C853(0.85)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C853(0.52)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C853(0.47)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C853(0.66); C790(1.15)  LDD1681  [1]
 LDCM0484  CL9 HEK-293T C853(0.82)  LDD1687  [1]
 LDCM0486  CL91 HEK-293T C853(1.01)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C853(0.91)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C853(0.66)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C853(0.58)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C853(0.81)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C853(0.88); C790(1.11)  LDD1694  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
REST corepressor 3 (RCOR3) CoREST family Q9P2K3
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM161A (FAM161A) FAM161 family Q3B820
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4) . Q8NA19
RNA-binding protein 41 (RBM41) . Q96IZ5
SH2 domain-containing protein 4A (SH2D4A) . Q9H788

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019