Details of the Target

General Information of Target

Target ID LDTP13801
Target Name Protein FAM50B (FAM50B)
Gene Name FAM50B
Gene ID 26240
Synonyms
X5L; Protein FAM50B; Protein XAP-5-like
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNARGLGSELKDSIPVTELSASGPFESHDLLRKGFSCVKNELLPSHPLELSEKNFQLNQD
KMNFSTLRNIQGLFAPLKLQMEFKAVQQVQRLPFLSSSNLSLDVLRGNDETIGFEDILND
PSQSEVMGEPHLMVEYKLGLL
Target Bioclass
Other
Family
FAM50 family
Uniprot ID
Q9Y247
Ensemble ID
ENST00000380274.2
HGNC ID
HGNC:18789

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C119(1.63)  LDD3332  [1]
HHS-475
 Probe Info  		Y53(0.68)  LDD0264  [2]
HHS-465
 Probe Info  		Y53(7.99)  LDD2237  [3]
Acrolein
 Probe Info  		N.A.  LDD0221  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C119(0.86)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C119(0.97)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C119(0.57)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C119(0.65)  LDD1510  [6]
 LDCM0270  AC15 HEK-293T C119(1.05)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C119(1.00)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C119(0.88)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C119(0.65)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C119(0.77)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C119(0.75)  LDD1519  [6]
 LDCM0283  AC23 HEK-293T C119(0.91)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C119(1.07)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C119(0.83)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C119(1.19)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C119(0.73)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C119(0.69)  LDD1527  [6]
 LDCM0290  AC3 HEK-293T C119(1.00)  LDD1529  [6]
 LDCM0292  AC31 HEK-293T C119(1.03)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C119(1.42)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C119(1.06)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C119(1.19)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C119(0.67)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C119(0.82)  LDD1536  [6]
 LDCM0300  AC39 HEK-293T C119(1.01)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C119(0.53)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C119(1.16)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C119(1.15)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C119(1.12)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C119(0.67)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C119(0.72)  LDD1545  [6]
 LDCM0309  AC47 HEK-293T C119(1.09)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C119(1.03)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C119(0.96)  LDD1550  [6]
 LDCM0313  AC50 HEK-293T C119(0.72)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C119(0.76)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C119(0.79)  LDD1554  [6]
 LDCM0318  AC55 HEK-293T C119(0.95)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C119(1.30)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C119(1.09)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C119(0.86)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C119(0.79)  LDD1561  [6]
 LDCM0324  AC60 HEK-293T C119(0.67)  LDD1563  [6]
 LDCM0327  AC63 HEK-293T C119(0.93)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C119(1.15)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C119(1.19)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C119(1.08)  LDD1569  [6]
 LDCM0356  AKOS034007680 HEK-293T C119(0.93)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C119(1.11)  LDD1514  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0369  CL100 HEK-293T C119(1.58)  LDD1573  [6]
 LDCM0373  CL104 HEK-293T C119(1.13)  LDD1577  [6]
 LDCM0377  CL108 HEK-293T C119(0.84)  LDD1581  [6]
 LDCM0379  CL11 HEK-293T C119(0.81)  LDD1583  [6]
 LDCM0382  CL112 HEK-293T C119(1.35)  LDD1586  [6]
 LDCM0386  CL116 HEK-293T C119(1.49)  LDD1590  [6]
 LDCM0390  CL12 HEK-293T C119(1.37)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C119(1.03)  LDD1595  [6]
 LDCM0395  CL124 HEK-293T C119(1.54)  LDD1599  [6]
 LDCM0399  CL128 HEK-293T C119(1.47)  LDD1603  [6]
 LDCM0403  CL16 HEK-293T C119(1.19)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C119(0.85)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C119(0.90)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C119(0.64)  LDD1610  [6]
 LDCM0408  CL20 HEK-293T C119(0.72)  LDD1612  [6]
 LDCM0411  CL23 HEK-293T C119(1.05)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C119(1.39)  LDD1616  [6]
 LDCM0416  CL28 HEK-293T C119(0.81)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C119(0.92)  LDD1621  [6]
 LDCM0419  CL30 HEK-293T C119(0.84)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C119(0.64)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C119(0.62)  LDD1625  [6]
 LDCM0424  CL35 HEK-293T C119(1.16)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C119(0.92)  LDD1629  [6]
 LDCM0429  CL4 HEK-293T C119(0.78)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C119(0.98)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C119(1.17)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C119(0.69)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C119(0.93)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C119(0.66)  LDD1638  [6]
 LDCM0437  CL47 HEK-293T C119(1.03)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C119(0.91)  LDD1642  [6]
 LDCM0440  CL5 HEK-293T C119(0.91)  LDD1644  [6]
 LDCM0443  CL52 HEK-293T C119(0.77)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C119(0.77)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C119(0.93)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C119(0.49)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C119(0.53)  LDD1650  [6]
 LDCM0450  CL59 HEK-293T C119(1.03)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C119(1.13)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C119(1.23)  LDD1655  [6]
 LDCM0456  CL64 HEK-293T C119(1.06)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C119(0.94)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C119(1.25)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C119(0.71)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C119(0.67)  LDD1663  [6]
 LDCM0462  CL7 HEK-293T C119(0.60)  LDD1665  [6]
 LDCM0464  CL71 HEK-293T C119(0.97)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C119(1.03)  LDD1668  [6]
 LDCM0469  CL76 HEK-293T C119(1.47)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C119(1.00)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C119(0.87)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C119(0.69)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C119(0.60)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C119(0.58)  LDD1677  [6]
 LDCM0477  CL83 HEK-293T C119(1.03)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C119(0.76)  LDD1681  [6]
 LDCM0482  CL88 HEK-293T C119(1.18)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C119(0.92)  LDD1686  [6]
 LDCM0485  CL90 HEK-293T C119(0.71)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C119(0.80)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C119(0.52)  LDD1690  [6]
 LDCM0490  CL95 HEK-293T C119(1.10)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C119(1.21)  LDD1694  [6]
 LDCM0116  HHS-0101 DM93 Y53(0.68)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y53(0.54)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y53(0.84)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y53(0.63)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y53(0.57)  LDD0268  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0022  KB02 COR-L88 C119(1.99)  LDD2311  [1]
 LDCM0023  KB03 A673 C119(0.95)  LDD2678  [1]
 LDCM0024  KB05 MKN45 C119(1.63)  LDD3332  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase Midline-1 (MID1) TRIM/RBCC family O15344
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Tripartite motif-containing protein 14 (TRIM14) TRIM/RBCC family Q14142
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-2 (ACTN2) Alpha-actinin family P35609
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
TBC1 domain family member 1 (TBC1D1) . Q86TI0
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 89 (CCDC89) CCDC89 family Q8N998
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Cyclin-C (CCNC) Cyclin family P24863
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Huntingtin-associated protein 1 (HAP1) . P54257
Nuclear transport factor 2 (NUTF2) . P61970
Protein KASH5 (KASH5) . Q8N6L0
Ubiquitin-like protein 5 (UBL5) . Q9BZL1
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402