Details of the Target

General Information of Target

Target ID LDTP13769
Target Name SH2B adapter protein 3 (SH2B3)
Gene Name SH2B3
Gene ID 10019
Synonyms
LNK; SH2B adapter protein 3; Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; Signal transduction protein Lnk
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQWTKVLGLGLGAAALLGLGIILGHFAIPKKANSLAPQDLDLEILETVMGQLDAHRIREN
LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV
GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ
GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP
PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG
TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD
RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL
IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD
LSIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARI
YPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFL
QAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQLM
LLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQL
SIVVTALEGAAATLRPVADL
Target Type
Literature-reported
Target Bioclass
Other
Family
SH2B adapter family
Function Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
TTD ID
T44585
Uniprot ID
Q9UQQ2
DrugMap ID
TT36N7Z
Ensemble ID
ENST00000341259.7
HGNC ID
HGNC:29605

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C254(1.88)  LDD3369  [1]
AHL-Pu-1
 Probe Info  		C450(3.60)  LDD0170  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C450(3.60)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C450(2.95)  LDD0171  [2]
 LDCM0216  AC100 PaTu 8988t C450(0.92); C454(0.92)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C450(1.06); C454(1.06)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C450(1.05); C454(1.05)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C450(1.20); C454(1.20)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C450(1.17); C454(1.17)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C450(1.07); C454(1.07)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C450(1.15); C454(1.15)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C450(1.20); C454(1.20)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C450(1.08); C454(1.08)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C450(1.11); C454(1.11)  LDD1104  [4]
 LDCM0227  AC110 PaTu 8988t C450(1.23); C454(1.23)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C450(1.19); C454(1.19)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C450(1.23); C454(1.23)  LDD1108  [4]
 LDCM0365  AC98 PaTu 8988t C450(1.07); C454(1.07)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C450(1.22); C454(1.22)  LDD1245  [4]
 LDCM0420  CL31 PaTu 8988t C450(1.22); C454(1.22)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C450(1.20); C454(1.20)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C450(1.66); C454(1.66)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C450(1.48); C454(1.48)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C450(1.25); C454(1.25)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C450(2.18); C454(2.18)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C450(1.29); C454(1.29)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C450(1.40); C454(1.40)  LDD1307  [4]
 LDCM0430  CL40 PaTu 8988t C450(1.02); C454(1.02)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C450(1.41); C454(1.41)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C450(1.12); C454(1.12)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C450(1.26); C454(1.26)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C450(1.08); C454(1.08)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C450(1.77); C454(1.77)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C450(1.29); C454(1.29)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C450(1.15); C454(1.15)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C450(1.21); C454(1.21)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C450(1.22); C454(1.22)  LDD1318  [4]
 LDCM0441  CL50 PaTu 8988t C450(1.52); C454(1.52)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C450(1.73); C454(1.73)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C450(1.16); C454(1.16)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C450(1.56); C454(1.56)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C450(1.20); C454(1.20)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C450(1.15); C454(1.15)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C450(1.21); C454(1.21)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C450(1.50); C454(1.50)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C450(1.05); C454(1.05)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C450(1.14); C454(1.14)  LDD1329  [4]
 LDCM0452  CL60 PaTu 8988t C450(1.22); C454(1.22)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C450(1.06); C454(1.06)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C450(1.16); C454(1.16)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C450(1.05); C454(1.05)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C450(1.70); C454(1.70)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C450(1.22); C454(1.22)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C450(1.24); C454(1.24)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C450(1.52); C454(1.52)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C450(1.91); C454(1.91)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C450(1.80); C454(1.80)  LDD1340  [4]
 LDCM0463  CL70 PaTu 8988t C450(1.15); C454(1.15)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C450(1.20); C454(1.20)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C450(0.93); C454(0.93)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C450(2.07); C454(2.07)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C450(1.31); C454(1.31)  LDD1346  [4]
 LDCM0468  Fragment33 PaTu 8988t C450(1.27); C454(1.27)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C450(1.10); C454(1.10)  LDD1306  [4]
 LDCM0022  KB02 MCAS C254(1.32)  LDD2449  [1]
 LDCM0023  KB03 MCAS C254(1.44)  LDD2866  [1]
 LDCM0024  KB05 OAW-42 C254(1.88)  LDD3369  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pazopanib Small molecular drug DB06589

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.