Details of the Target

General Information of Target

Target ID LDTP13747
Target Name Sialidase-3 (NEU3)
Gene Name NEU3
Gene ID 10825
Synonyms
Sialidase-3; EC 3.2.1.18; Ganglioside sialidasedis; Membrane sialidase; N-acetyl-alpha-neuraminidase 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDH
ERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTE
THQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSS
RSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKS
KDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPAS
GRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTG
PEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSES
SPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRR
MGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRP
GWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPT
RRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRS
RTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQR
RGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLS
GSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSP
HPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVK
SSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVE
SRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEK
SKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSH
SESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQS
DSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSL
VFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSEL
KEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNS
PLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSG
HSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSR
SGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSP
SSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESD
SSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDS
SPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKT
KSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSR
SSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR
RQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAP
WKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSR
RRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRR
RSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRK
RSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHS
GSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGP
GPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSL
RTAPAANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPS
AVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVG
PRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPP
LLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSR
CLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSA
LAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVP
SPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRR
PSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSRSP
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 33 family
Subcellular location
Cell membrane
Function
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes.
Uniprot ID
Q9UQ49
Ensemble ID
ENST00000294064.9
HGNC ID
HGNC:7760
ChEMBL ID
CHEMBL3046

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C136(1.94)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [3]
Lodoacetamide azide
 Probe Info  		C295(0.00); C226(0.00)  LDD0037  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C273(1.14); C279(1.14)  LDD1093  [2]
 LDCM0215  AC10 PaTu 8988t C273(1.54); C279(1.54)  LDD1094  [2]
 LDCM0226  AC11 PaTu 8988t C273(1.00); C279(1.00)  LDD1105  [2]
 LDCM0237  AC12 PaTu 8988t C273(1.00); C279(1.00)  LDD1116  [2]
 LDCM0259  AC14 PaTu 8988t C273(0.70); C279(0.70)  LDD1138  [2]
 LDCM0270  AC15 PaTu 8988t C273(0.84); C279(0.84)  LDD1149  [2]
 LDCM0276  AC17 HEK-293T C415(1.29)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C415(0.99)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C415(1.32)  LDD1517  [6]
 LDCM0279  AC2 PaTu 8988t C273(1.37); C279(1.37)  LDD1158  [2]
 LDCM0280  AC20 HEK-293T C415(0.95)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C415(0.97)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C415(0.87)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C415(1.46); C226(0.81); C242(1.06)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C415(1.02)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C415(1.24)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C415(0.97)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C415(0.94)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C415(1.02)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C415(1.08)  LDD1528  [6]
 LDCM0290  AC3 PaTu 8988t C273(1.42); C279(1.42)  LDD1169  [2]
 LDCM0291  AC30 HEK-293T C415(0.90)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C415(0.93); C226(1.16); C242(1.17)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C415(0.99)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C415(1.05)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C415(0.92)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C415(0.97)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C415(1.19)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C415(0.93)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C415(1.06)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C415(1.05); C226(1.24); C242(0.96)  LDD1539  [6]
 LDCM0301  AC4 PaTu 8988t C273(1.08); C279(1.08)  LDD1180  [2]
 LDCM0302  AC40 HEK-293T C415(1.11)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C415(1.03)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C415(0.96)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C415(1.04)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C415(1.04)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C415(1.11)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C415(1.11)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C415(0.97)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C415(1.17)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C415(1.05)  LDD0909  [2]
 LDCM0312  AC5 PaTu 8988t C273(2.43); C279(2.43)  LDD1191  [2]
 LDCM0313  AC50 HEK-293T C415(1.10)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C415(1.03)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C415(1.00)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C415(0.92)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C415(1.19)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C415(1.00)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C415(1.16)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C415(0.95)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C415(0.89)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C415(0.93)  LDD0920  [2]
 LDCM0323  AC6 PaTu 8988t C273(1.29); C279(1.29)  LDD1202  [2]
 LDCM0324  AC60 HEK-293T C415(0.81)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C415(0.85)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C415(0.84)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C415(0.75)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C415(0.71)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C415(0.76)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C415(0.84)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C415(0.76)  LDD0929  [2]
 LDCM0334  AC7 PaTu 8988t C273(1.13); C279(1.13)  LDD1213  [2]
 LDCM0345  AC8 PaTu 8988t C273(0.82); C279(0.82)  LDD1224  [2]
 LDCM0349  AC83 HEK-293T C415(0.85)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C415(0.89)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C415(0.89)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C415(0.84)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C415(0.87)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C415(0.94)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C415(0.92)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C415(0.82)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C415(0.89)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C415(0.81)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C415(0.69)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C415(0.98)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C415(0.80)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C415(0.86)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C415(0.95)  LDD0962  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C273(1.66); C279(1.66)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C273(1.23); C279(1.23)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C273(1.62); C279(1.62)  LDD1154  [2]
 LDCM0367  CL1 PaTu 8988t C273(1.07); C279(1.07)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C273(1.28); C279(1.28)  LDD1247  [2]
 LDCM0369  CL100 PaTu 8988t C273(0.97); C279(0.97)  LDD1248  [2]
 LDCM0370  CL101 PaTu 8988t C273(1.39); C279(1.39)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C273(1.20); C279(1.20)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C273(1.22); C279(1.22)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C273(1.39); C279(1.39)  LDD1252  [2]
 LDCM0374  CL105 HEK-293T C415(1.05)  LDD1578  [6]
 LDCM0376  CL107 HEK-293T C415(1.11)  LDD1580  [6]
 LDCM0378  CL109 HEK-293T C415(1.03)  LDD1582  [6]
 LDCM0379  CL11 PaTu 8988t C273(0.93); C279(0.93)  LDD1258  [2]
 LDCM0381  CL111 HEK-293T C415(0.95)  LDD1585  [6]
 LDCM0383  CL113 HEK-293T C415(1.04)  LDD1587  [6]
 LDCM0385  CL115 HEK-293T C415(0.91)  LDD1589  [6]
 LDCM0387  CL117 HEK-293T C415(1.01)  LDD1591  [6]
 LDCM0389  CL119 HEK-293T C415(1.15)  LDD1593  [6]
 LDCM0390  CL12 PaTu 8988t C273(1.39); C279(1.39)  LDD1269  [2]
 LDCM0392  CL121 HEK-293T C415(1.10)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C415(1.11)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C415(1.20)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C415(0.96)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C415(0.85)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C415(0.88)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C415(0.90)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C415(0.85)  LDD0997  [2]
 LDCM0400  CL13 PaTu 8988t C273(1.46); C279(1.46)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C273(1.40); C279(1.40)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C273(1.26); C279(1.26)  LDD1281  [2]
 LDCM0403  CL16 HEK-293T C415(0.84)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C415(0.36)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C415(1.05)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C415(1.13)  LDD1004  [2]
 LDCM0407  CL2 PaTu 8988t C273(0.92); C279(0.92)  LDD1286  [2]
 LDCM0408  CL20 HEK-293T C415(0.99)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C415(0.93)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C415(1.01)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C415(0.97)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C415(1.03)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C415(0.86)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C415(0.89)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C415(0.99)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C415(0.96)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C415(0.87)  LDD1015  [2]
 LDCM0418  CL3 PaTu 8988t C273(1.51); C279(1.51)  LDD1297  [2]
 LDCM0419  CL30 HEK-293T C415(1.09)  LDD1017  [2]
 LDCM0420  CL31 PaTu 8988t C273(1.14); C279(1.14)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C273(1.56); C279(1.56)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C273(1.78); C279(1.78)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C273(1.60); C279(1.60)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C273(1.64); C279(1.64)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C273(1.79); C279(1.79)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C273(2.32); C279(2.32)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C273(1.86); C279(1.86)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C273(1.36); C279(1.36)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C273(1.38); C279(1.38)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C273(1.63); C279(1.63)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C273(2.14); C279(2.14)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C273(2.30); C279(2.30)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C273(1.97); C279(1.97)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C273(1.94); C279(1.94)  LDD1314  [2]
 LDCM0436  CL46 HEK-293T C415(1.04)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C415(1.29); C226(1.24); C242(1.11)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C415(1.04)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C415(1.04)  LDD1643  [6]
 LDCM0440  CL5 PaTu 8988t C273(1.24); C279(1.24)  LDD1319  [2]
 LDCM0444  CL53 HEK-293T C415(1.00)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C415(0.94)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C415(1.04)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C415(1.31)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C415(1.11)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C415(1.10)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C415(1.27); C226(1.32); C242(0.90)  LDD1653  [6]
 LDCM0451  CL6 PaTu 8988t C273(1.57); C279(1.57)  LDD1330  [2]
 LDCM0452  CL60 HEK-293T C415(0.67)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C415(1.01)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C415(0.84)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C415(0.82)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C415(1.07)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C415(1.01)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C415(1.07)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C415(1.10)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C415(0.99)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C415(0.99)  LDD1059  [2]
 LDCM0462  CL7 PaTu 8988t C273(1.38); C279(1.38)  LDD1341  [2]
 LDCM0463  CL70 HEK-293T C415(1.16)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C415(0.98)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C415(0.96)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C415(0.95)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C415(0.99)  LDD1065  [2]
 LDCM0470  CL77 HEK-293T C415(1.49)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C415(1.02)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C415(0.95)  LDD1675  [6]
 LDCM0473  CL8 PaTu 8988t C273(0.99); C279(0.99)  LDD1352  [2]
 LDCM0474  CL80 HEK-293T C415(1.12)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C415(1.02)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C415(1.04)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C415(1.30); C226(1.24); C242(1.06)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C415(1.05)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C415(0.92)  LDD1682  [6]
 LDCM0481  CL87 HEK-293T C415(0.90)  LDD1684  [6]
 LDCM0483  CL89 HEK-293T C415(1.00)  LDD1686  [6]
 LDCM0484  CL9 PaTu 8988t C273(1.55); C279(1.55)  LDD1363  [2]
 LDCM0485  CL90 HEK-293T C415(0.97)  LDD1688  [6]
 LDCM0486  CL91 PaTu 8988t C273(1.21); C279(1.21)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C273(2.76); C279(2.76)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C273(1.28); C279(1.28)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C273(0.93); C279(0.93)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C273(1.17); C279(1.17)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C273(1.41); C279(1.41)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C273(1.45); C279(1.45)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C273(1.16); C279(1.16)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C273(1.22); C279(1.22)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C415(0.93)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C415(0.93)  LDD1066  [2]
 LDCM0427  Fragment51 PaTu 8988t C273(1.54); C279(1.54)  LDD1306  [2]
 LDCM0022  KB02 HCT 116 C136(1.94)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C136(1.45)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C136(1.75)  LDD0082  [2]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402