Details of the Target

General Information of Target

Target ID LDTP13563
Target Name Zinc finger protein 490 (ZNF490)
Gene Name ZNF490
Gene ID 57474
Synonyms
KIAA1198; Zinc finger protein 490
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MENRPGSFQYVPVQLQGGAPWGFTLKGGLEHCEPLTVSKIEDGGKAALSQKMRTGDELVN
INGTPLYGSRQEALILIKGSFRILKLIVRRRNAPVSRPHSWHVAKLLEGCPEAATTMHFP
SEAFSLSWHSGCNTSDVCVQWCPLSRHCSTEKSSSIGSMESLEQPGQATYESHLLPIDQN
MYPNQRDSAYSSFSASSNASDCALSLRPEEPASTDCIMQGPGPTKAPSGRPNVAETSGGS
RRTNGGHLTPSSQMSSRPQEGYQSGPAKAVRGPPQPPVRRDSLQASRAQLLNGEQRRASE
PVVPLPQKEKLSLEPVLPARNPNRFCCLSGHDQVTSEGHQNCEFSQPPESSQQGSEHLLM
QASTKAVGSPKACDRASSVDSNPLNEASAELAKASFGRPPHLIGPTGHRHSAPEQLLASH
LQHVHLDTRGSKGMELPPVQDGHQWTLSPLHSSHKGKKSPCPPTGGTHDQSSKERKTRQV
DDRSLVLGHQSQSSPPHGEADGHPSEKGFLDPNRTSRAASELANQQPSASGSLVQQATDC
SSTTKAASGTEAGEEGDSEPKECSRMGGRRSGGTRGRSIQNRRKSERFATNLRNEIQRRK
AQLQKSKGPLSQLCDTKEPVEETQEPPESPPLTASNTSLLSSCKKPPSPRDKLFNKSMML
RARSSECLSQAPESHESRTGLEGRISPGQRPGQSSLGLNTWWKAPDPSSSDPEKAHAHCG
VRGGHWRWSPEHNSQPLVAAAMEGPSNPGDNKELKASTAQAGEDAILLPFADRRKFFEES
SKSLSTSHLPGLTTHSNKTFTQRPKPIDQNFQPMSSSCRELRRHPMDQSYHSADQPYHAT
DQSYHSMSPLQSETPTYSECFASKGLENSMCCKPLHCGDFDYHRTCSYSCSVQGALVHDP
CIYCSGEICPALLKRNMMPNCYNCRCHHHQCIRCSVCYHNPQHSALEDSSLAPGNTWKPR
KLTVQEFPGDKWNPITGNRKTSQSGREMAHSKTSFSWATPFHPCLENPALDLSSYRAISS
LDLLGDFKHALKKSEETSVYEEGSSLASMPHPLRSRAFSESHISLAPQSTRAWGQHRREL
FSKGDETQSDLLGARKKAFPPPRPPPPNWEKYRLFRAAQQQKQQQQQQKQQEEEEEEEEE
EEEEEEEEEEEAEEEEEELPPQYFSSETSGSCALNPEEVLEQPQPLSFGHLEGSRQGSQS
VPAEQESFALHSSDFLPPIRGHLGSQPEQAQPPCYYGIGGLWRTSGQEATESAKQEFQHF
SPPSGAPGIPTSYSAYYNISVAKAELLNKLKDQPEMAEIGLGEEEVDHELAQKKIQLIES
ISRKLSVLREAQRGLLEDINANSALGEEVEANLKAVCKSNEFEKYHLFVGDLDKVVNLLL
SLSGRLARVENALNSIDSEANQEKLVLIEKKQQLTGQLADAKELKEHVDRREKLVFGMVS
RYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLRESLLLGPSNF
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9ULM2
Ensemble ID
ENST00000311437.11
HGNC ID
HGNC:23705

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C308(2.31)  LDD0170  [1]
DBIA
 Probe Info  		C133(25.53); C485(13.73); C317(20.86)  LDD0209  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C308(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C308(2.25)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C485(0.96)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C485(1.07)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C485(0.95)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C485(0.91)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C485(1.08)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C485(1.25)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C485(1.07)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C485(1.10)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C485(2.35)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C485(0.97)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C485(1.07)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C485(0.86)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C485(0.90)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C485(0.96)  LDD1522  [5]
 LDCM0285  AC25 HEK-293T C485(0.97)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C485(0.96)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C485(0.94)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C485(1.00)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C485(0.91)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C485(1.10)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C485(0.89)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C485(1.04)  LDD1531  [5]
 LDCM0294  AC33 HEK-293T C485(0.97)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C485(1.03)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C485(1.10)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C485(0.93)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C485(0.84)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C485(0.93)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C485(0.98)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C485(1.02)  LDD1540  [5]
 LDCM0303  AC41 HEK-293T C485(0.99)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C485(1.16)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C485(1.04)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C485(1.02)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C485(0.99)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C485(0.84)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C485(1.16)  LDD1548  [5]
 LDCM0311  AC49 HEK-293T C485(0.97)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C485(0.94)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C485(1.05)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C485(0.95)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C485(1.05)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C485(0.89)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C485(1.00)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C485(0.89)  LDD1557  [5]
 LDCM0320  AC57 HEK-293T C485(1.01)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C485(0.99)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C485(0.99)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C485(0.85)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C485(0.97)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C485(0.98)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C485(0.90)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C485(0.98)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C485(1.07)  LDD1568  [5]
 LDCM0248  AKOS034007472 HEK-293T C485(0.89)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C485(1.10)  LDD1570  [5]
 LDCM0367  CL1 HEK-293T C485(1.00)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C485(1.24)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C485(1.07)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C485(0.98)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C485(1.01)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C485(1.00)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C485(1.02)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C485(0.95)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C485(1.06)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C485(0.99)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C485(0.98)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C485(0.97)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C485(1.11)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C485(1.16)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C485(1.05)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C485(1.09)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C485(0.92)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C485(1.09)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C485(1.06)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C485(1.01)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C485(0.99)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C485(1.08)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C485(0.98)  LDD1593  [5]
 LDCM0391  CL120 HEK-293T C485(1.05)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C485(0.99)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C485(1.05)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C485(0.96)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C485(1.03)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C485(1.06)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C485(1.06)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C485(1.04)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C485(1.00)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C485(1.02)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C485(1.12)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C485(1.02)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C485(1.07)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C485(1.14)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C485(1.05)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C485(1.12)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C485(1.24)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C485(0.95)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C485(0.93)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C485(1.05)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C485(0.99)  LDD1615  [5]
 LDCM0413  CL25 HEK-293T C485(0.94)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C485(1.02)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C485(0.99)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C485(1.08)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C485(0.98)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C485(0.99)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C485(1.00)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C485(1.01)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C485(1.00)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C485(1.01)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C485(0.98)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C485(0.98)  LDD1628  [5]
 LDCM0426  CL37 HEK-293T C485(0.97)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C485(1.16)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C485(1.03)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C485(1.04)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C485(1.04)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C485(1.00)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C485(0.88)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C485(0.99)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C485(1.22)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C485(0.96)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C485(1.15)  LDD1641  [5]
 LDCM0439  CL49 HEK-293T C485(0.95)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C485(1.03)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C485(1.06)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C485(1.05)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C485(1.08)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C485(0.85)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C485(0.94)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C485(1.05)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C485(1.05)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C485(0.78)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C485(0.97)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C485(1.15)  LDD1654  [5]
 LDCM0453  CL61 HEK-293T C485(1.07)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C485(1.01)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C485(0.95)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C485(1.09)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C485(1.03)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C485(1.24)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C485(0.94)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C485(1.03)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C485(0.97)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C485(0.99)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C485(0.83)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C485(1.06)  LDD1667  [5]
 LDCM0466  CL73 HEK-293T C485(0.96)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C485(1.10)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C485(0.99)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C485(1.21)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C485(0.95)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C485(0.91)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C485(1.06)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C485(0.98)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C485(0.88)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C485(0.93)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C485(0.97)  LDD1680  [5]
 LDCM0479  CL85 HEK-293T C485(0.95)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C485(1.18)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C485(1.05)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C485(1.06)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C485(0.98)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C485(1.23)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C485(1.33)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C485(0.97)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C485(1.08)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C485(0.95)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C485(1.00)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C485(1.25)  LDD1693  [5]
 LDCM0492  CL97 HEK-293T C485(0.99)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C485(1.06)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C485(0.98)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C485(1.23)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C485(0.98)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C485(1.05)  LDD1631  [5]
 LDCM0022  KB02 786-O C485(4.73)  LDD2247  [6]
 LDCM0023  KB03 Jurkat C133(25.53); C485(13.73); C317(20.86)  LDD0209  [2]
 LDCM0024  KB05 NB1 C485(3.95)  LDD3340  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Glutaredoxin-3 (GLRX3) . O76003
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Syntaxin-1A (STX1A) Syntaxin family Q16623
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Brorin (VWC2) . Q2TAL6
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Huntingtin-associated protein 1 (HAP1) . P54257
Testis-expressed protein 19 (TEX19) . Q8NA77
TNF receptor-associated factor 1 (TRAF1) . Q13077
Zinc finger C4H2 domain-containing protein (ZC4H2) . Q9NQZ6

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840