Details of the Target

General Information of Target

Target ID LDTP13374
Target Name Zinc finger MYM-type protein 5 (ZMYM5)
Gene Name ZMYM5
Gene ID 9205
Synonyms
ZNF198L1; ZNF237; Zinc finger MYM-type protein 5; Zinc finger protein 198-like 1; Zinc finger protein 237
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTVEKEAPDAHFTVDKQNISLWPREPPPKSGPSLVPGKTPTVRAALICLTLVLVASVLLQ
AVLYPRFMGTISDVKTNVQLLKGRVDNISTLDSEIKKNSDGMEAAGVQIQMVNESLGYVR
SQFLKLKTSVEKANAQIQILTRSWEEVSTLNAQIPELKSDLEKASALNTKIRALQGSLEN
MSKLLKRQNDILQVVSQGWKYFKGNFYYFSLIPKTWYSAEQFCVSRNSHLTSVTSESEQE
FLYKTAGGLIYWIGLTKAGMEGDWSWVDDTPFNKVQSVRFWIPGEPNNAGNNEHCGNIKA
PSLQAWNDAPCDKTFLFICKRPYVPSEP
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Functions as a transcriptional regulator.
Uniprot ID
Q9UJ78
Ensemble ID
ENST00000337963.9
HGNC ID
HGNC:13029

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C137(1.10)  LDD0533  [1]
SF
 Probe Info  		N.A.  LDD0028  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C137(1.04)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C289(0.91)  LDD1508  [3]
 LDCM0216  AC100 HCT 116 C137(1.10)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C137(1.06)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C137(1.12)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C137(1.27)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C137(1.26)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C137(1.18)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C137(1.26)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C137(1.24)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C137(1.12)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C137(0.98)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C289(0.98)  LDD1509  [3]
 LDCM0227  AC110 HCT 116 C137(1.12)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C137(1.08)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C137(1.20)  LDD0546  [1]
 LDCM0263  AC143 HCT 116 C341(0.83)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C341(0.68)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C341(0.73)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C341(0.58)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C341(0.59)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C341(0.52)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C341(0.55)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C341(0.77)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C341(0.72)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C341(0.62)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C341(0.49)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C341(0.62)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C341(0.60)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C341(0.82)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C341(0.82)  LDD2161  [1]
 LDCM0276  AC17 PaTu 8988t C137(0.92)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C137(1.23)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C137(1.00)  LDD1157  [1]
 LDCM0279  AC2 HEK-293T C289(1.06)  LDD1518  [3]
 LDCM0280  AC20 PaTu 8988t C137(1.11)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C137(0.96)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C137(1.23)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C137(1.37)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C137(1.28)  LDD1163  [1]
 LDCM0285  AC25 PaTu 8988t C137(1.07)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C137(1.08)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C137(1.37)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C137(1.79)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C137(1.23)  LDD1168  [1]
 LDCM0290  AC3 HEK-293T C289(0.85)  LDD1529  [3]
 LDCM0291  AC30 PaTu 8988t C137(1.09)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C137(1.04)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C137(1.12)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C137(1.63)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C137(1.04)  LDD1174  [1]
 LDCM0296  AC35 HEK-293T C289(0.91)  LDD1535  [3]
 LDCM0303  AC41 HEK-293T C137(1.33)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C289(0.93)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C289(0.88)  LDD1544  [3]
 LDCM0308  AC46 HCT 116 C341(0.81)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C341(0.90)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C341(0.93)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C341(0.88)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C341(0.91)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C341(0.88)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C341(0.78)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C341(0.79)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C341(0.90)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C341(0.85)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C341(0.80)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C137(1.26)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C289(1.02)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C289(0.97)  LDD1561  [3]
 LDCM0332  AC68 HCT 116 C341(0.93)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C341(0.83)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C341(0.68)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C341(1.04)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C341(1.01)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C341(0.86)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C341(0.79)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C341(0.77)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C341(0.97)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C341(1.03)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C341(0.91)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C341(1.01)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C341(1.02)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C341(1.02)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C341(0.70)  LDD0665  [1]
 LDCM0349  AC83 PaTu 8988t C137(0.71)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C137(0.79)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C137(1.44)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C137(0.77)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C137(0.66)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C137(0.74)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C137(1.04)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C137(0.74)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C137(0.72)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C137(0.81)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C137(0.49)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C137(0.83)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C137(0.62)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C137(0.71)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C137(0.62)  LDD1243  [1]
 LDCM0365  AC98 HCT 116 C137(1.12)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C137(1.15)  LDD0683  [1]
 LDCM0356  AKOS034007680 HEK-293T C137(1.20)  LDD1570  [3]
 LDCM0367  CL1 HCT 116 C137(1.06); C341(1.08)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C137(1.03); C341(1.21)  LDD0685  [1]
 LDCM0374  CL105 PaTu 8988t C137(1.05)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C137(1.08)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C137(0.97)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C137(1.10)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C137(1.21)  LDD1257  [1]
 LDCM0379  CL11 HCT 116 C137(1.09); C341(1.21)  LDD0696  [1]
 LDCM0380  CL110 PaTu 8988t C137(1.38)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C137(1.42)  LDD1260  [1]
 LDCM0382  CL112 PaTu 8988t C137(1.13)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C137(1.05)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C137(1.21)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C137(1.17)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C137(1.35)  LDD1265  [1]
 LDCM0390  CL12 HCT 116 C137(0.99); C341(1.31)  LDD0707  [1]
 LDCM0392  CL121 HCT 116 C341(1.06)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C341(0.87)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C341(0.97)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C341(0.77)  LDD0712  [1]
 LDCM0400  CL13 HCT 116 C137(0.92); C341(1.16)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C137(1.07); C341(1.14)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C341(0.84); C137(0.94)  LDD0719  [1]
 LDCM0404  CL17 HEK-293T C137(0.99)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C289(1.08)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C289(0.95)  LDD1610  [3]
 LDCM0407  CL2 HCT 116 C341(0.77); C137(1.00)  LDD0724  [1]
 LDCM0417  CL29 HEK-293T C137(0.90)  LDD1621  [3]
 LDCM0418  CL3 HCT 116 C137(0.89); C341(0.87)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C289(0.99)  LDD1623  [3]
 LDCM0420  CL31 PaTu 8988t C137(1.07)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C137(1.31)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C137(1.66)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C137(1.66)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C137(1.75)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C137(1.52)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C137(1.87)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C137(1.40)  LDD1307  [1]
 LDCM0429  CL4 HCT 116 C137(1.06); C341(1.06)  LDD0746  [1]
 LDCM0430  CL40 PaTu 8988t C137(1.48)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C137(1.47)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C137(1.79)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C137(2.26)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C137(1.61)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C137(1.40)  LDD1314  [1]
 LDCM0436  CL46 HCT 116 C137(0.77)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C137(0.70)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C137(0.66)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C137(0.88)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C137(0.90); C341(0.95)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C137(0.79)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C137(0.79)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C137(0.93)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C137(0.74)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C137(0.79)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C137(0.80)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C137(0.84)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C137(0.95)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C137(0.84)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C137(0.87)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C137(1.06); C341(0.87)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C137(0.86)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C137(1.16)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C137(1.27)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C137(1.44)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C137(1.40)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C137(1.37)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C137(1.48)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C137(1.80)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C137(1.27)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C137(1.40)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C137(0.81); C341(1.29)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C137(1.35)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C137(1.40)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C137(1.28)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C137(1.56)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C137(1.40)  LDD0784  [1]
 LDCM0469  CL76 PaTu 8988t C137(1.15)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C137(1.08)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C137(1.26)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C137(0.96)  LDD1351  [1]
 LDCM0473  CL8 HCT 116 C137(2.56); C341(0.88)  LDD0790  [1]
 LDCM0474  CL80 PaTu 8988t C137(1.37)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C137(1.25)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C137(1.19)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C137(1.09)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C137(1.33)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C137(1.00)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C137(1.26)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C137(1.71)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C137(1.53)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C137(1.50)  LDD1362  [1]
 LDCM0484  CL9 HCT 116 C137(1.00); C341(1.31)  LDD0801  [1]
 LDCM0485  CL90 PaTu 8988t C137(1.59)  LDD1364  [1]
 LDCM0486  CL91 HEK-293T C289(0.91)  LDD1689  [3]
 LDCM0468  Fragment33 HCT 116 C137(1.47)  LDD0785  [1]
 LDCM0427  Fragment51 PaTu 8988t C137(1.88)  LDD1306  [1]
 LDCM0022  KB02 A101D C137(1.69)  LDD2250  [4]
 LDCM0024  KB05 A101D C137(1.58)  LDD3084  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Paired box protein Pax-5 (PAX5) . Q02548
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homer protein homolog 1 (HOMER1) Homer family Q86YM7
Desmin (DES) Intermediate filament family P17661
Late cornified envelope protein 3B (LCE3B) LCE family Q5TA77
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
FAS-associated death domain protein (FADD) . Q13158
Protein TFG (TFG) . Q92734
Protein ZNRD2 (ZNRD2) . O60232
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840