Details of the Target

General Information of Target

Target ID LDTP13326
Target Name Dachshund homolog 1 (DACH1)
Gene Name DACH1
Gene ID 1602
Synonyms
DACH; Dachshund homolog 1; Dach1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQPRPQLDLKASR
KLPKLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRS
LAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILA
RGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLK
VIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHC
FEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDS
WEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKM
FQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPP
GSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQ
EPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHK
MEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCV
LQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGM
QLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEA
NASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFR
RAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGIL
TSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQR
VQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMVPKKQPERCLP
KGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHL
ENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLINL
MELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFF
SGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWM
DIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGG
QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNM
ISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLS
IVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNI
GLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPM
LRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE
DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL
HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAII
QKAFRKYMMKVTKGDQGDQNDLENGPHSPLQTLCNGDLSSFGVAKGKVHCD
Target Bioclass
Transcription factor
Family
DACH/dachshund family
Subcellular location
Nucleus
Function
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.
Uniprot ID
Q9UI36
Ensemble ID
ENST00000613252.5
HGNC ID
HGNC:2663

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C243(3.05)  LDD3370  [1]
IA-alkyne
 Probe Info  		C279(0.00); C243(0.00); C206(0.00)  LDD0165  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C243(0.87)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C243(1.09)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C243(0.98)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C243(1.00); C206(0.97)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C243(0.90)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C243(1.15)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C243(0.93)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C243(0.99)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C243(0.87)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C243(0.99)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C243(0.95); C206(0.97)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C279(1.07)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C243(0.86)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C243(1.10)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C243(1.07); C279(0.92)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C243(0.95)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C243(1.00)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C243(0.99)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C243(0.93); C206(0.90)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C279(1.03)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C243(0.97)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C243(1.26)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C243(0.94)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C243(1.14); C279(1.15)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C243(1.15)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C243(1.08)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C243(1.04)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C243(0.94); C206(0.98)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C279(1.07)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C243(1.01)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C243(0.96)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C243(0.86); C206(0.92)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C243(1.14); C279(1.09)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C243(0.92)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C243(1.15)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C243(1.02)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C243(0.95); C206(1.12)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C279(1.01)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C243(1.01)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C243(0.97)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C243(1.03); C279(1.20)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C243(1.01)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C279(1.11)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C243(1.11)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C243(1.01)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C243(1.04); C206(0.97)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C279(1.30)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C243(0.92)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C243(1.03)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C243(1.00); C279(1.07)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C243(1.10)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C243(1.17)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C243(1.07)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C243(0.72)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C243(0.82); C206(0.88)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C279(1.03)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C243(0.84)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C243(1.11)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C243(0.91); C279(1.47)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C243(1.06)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C243(1.17); C279(1.33)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C279(0.97)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C243(1.07)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C243(1.18); C279(1.08)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C243(1.22)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C243(1.10)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C243(1.25)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C243(0.96)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C243(1.09)  LDD1576  [3]
 LDCM0374  CL105 HEK-293T C243(0.93)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C243(1.06)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C243(1.05)  LDD1580  [3]
 LDCM0378  CL109 HEK-293T C243(0.90)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C243(1.26)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C243(0.88)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C243(0.96)  LDD1585  [3]
 LDCM0383  CL113 HEK-293T C243(0.94)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C243(0.99)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C243(1.13)  LDD1589  [3]
 LDCM0387  CL117 HEK-293T C243(1.01)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C243(0.97)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C243(1.05)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C243(1.15); C279(0.58)  LDD1594  [3]
 LDCM0392  CL121 HEK-293T C243(1.01)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C243(0.92)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C243(0.90)  LDD1598  [3]
 LDCM0396  CL125 HEK-293T C243(0.98)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C243(0.87)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C243(0.94)  LDD1602  [3]
 LDCM0400  CL13 HEK-293T C243(1.12)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C243(1.16)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C243(1.05)  LDD1606  [3]
 LDCM0404  CL17 HEK-293T C243(1.03)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C243(1.29)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C243(1.08)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C243(1.11)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C243(1.14); C206(0.98)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C279(0.58)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C243(1.19)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C243(1.44)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C243(1.22); C279(0.69)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C243(1.04)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C243(0.97)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C243(1.06)  LDD1619  [3]
 LDCM0417  CL29 HEK-293T C243(1.13)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C243(1.14)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C243(1.10)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C243(1.01)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C243(1.07); C206(1.09)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C279(0.57)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C243(1.33)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C243(1.41)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C243(1.01); C279(0.63)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C243(1.11)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C243(1.08)  LDD1632  [3]
 LDCM0431  CL41 HEK-293T C243(1.23)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C243(1.00)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C243(1.10)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C243(1.22); C206(0.96)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C279(0.67)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C243(1.10)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C243(1.40)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C243(1.15); C279(0.95)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C243(0.97)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C243(1.01)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C243(1.14)  LDD1645  [3]
 LDCM0444  CL53 HEK-293T C243(1.03)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C243(1.04)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C243(1.11)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C243(1.05); C206(0.97)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C279(0.74)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C243(1.09)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C243(1.83)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C243(1.01)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C243(1.12); C279(0.72)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C243(1.02)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C243(0.92)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C243(1.02)  LDD1658  [3]
 LDCM0457  CL65 HEK-293T C243(1.02)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C243(1.12)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C243(1.04)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C243(1.20); C206(0.86)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C279(0.91)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C243(0.99)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C243(1.05)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C243(1.24)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C243(1.20); C279(0.75)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C243(1.08)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C243(0.98)  LDD1670  [3]
 LDCM0470  CL77 HEK-293T C243(0.99)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C243(1.18)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C243(1.09)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C243(0.92); C206(0.73)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C243(1.01); C206(1.01)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C279(0.86)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C243(1.15)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C243(1.27)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C243(1.11); C279(0.80)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C243(0.96)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C243(0.94)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C243(0.79)  LDD1684  [3]
 LDCM0483  CL89 HEK-293T C243(1.01)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C279(0.71)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C243(1.01)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C243(1.10)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C243(1.00); C206(0.99)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C279(0.77)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C243(0.96)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C243(1.09)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C243(1.05); C279(0.93)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C243(1.05)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C243(0.91)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C243(0.89)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C243(1.00)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C243(1.00)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C243(0.96)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C279(1.01); C243(0.95)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C279(1.01); C243(1.00)  LDD1497  [3]
 LDCM0024  KB05 OCI-AML-2 C243(3.05)  LDD3370  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) Adenosylhomocysteinase family O43865
N-acetyl-D-glucosamine kinase (NAGK) Eukaryotic-type N-acetylglucosamine kinase family Q9UJ70
E3 ubiquitin-protein ligase RNF14 (RNF14) RBR family Q9UBS8
Peptidyl-prolyl cis-trans isomerase G (PPIG) . Q13427
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 4 (SMAD4) Dwarfin/SMAD family Q13485
Nuclear receptor corepressor 1 (NCOR1) N-CoR nuclear receptor corepressors family O75376
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Fibroblast growth factor 12 (FGF12) Heparin-binding growth factors family P61328
Splicing factor U2AF 65 kDa subunit (U2AF2) Splicing factor SR family P26368
Multiple myeloma tumor-associated protein 2 (MMTAG2) . Q9BU76
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402