Details of the Target

General Information of Target

Target ID LDTP13165
Target Name Protein Wnt-16 (WNT16)
Gene Name WNT16
Gene ID 51384
Synonyms
Protein Wnt-16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVRIGLTLLLCAVLLSLASASSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIF
LDSEESELESSIQEEEDSLKSQEGESVTEDISFLESPNPENKDYEEPKKVRKPALTAIEG
TAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQM
QEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQ
AAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYR
YWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDL
IQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMY
SEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQ
GWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCH
TAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQR
EASIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQ
QHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQY
IRETNIRDMFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDMPAPRPPGPRPA
PPQQEGPPEQQPPQ
Target Bioclass
Other
Family
Wnt family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Uniprot ID
Q9UBV4
Ensemble ID
ENST00000222462.3
HGNC ID
HGNC:16267

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.G167AfsTer17 .
CCK81 Deletion: p.G167AfsTer17 .
DU145 SNV: p.C223Y .
HCT116 Deletion: p.G167AfsTer17 .
Ishikawa (Heraklio) 02 ER SNV: p.C168R .
MDAMB468 SNV: p.D273H .
MFE319 Deletion: p.R354del .
RKO Deletion: p.G167AfsTer17 .
SUPT1 Deletion: p.G167AfsTer17 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C223(0.77); C230(0.77); C355(1.03); C364(1.03)  LDD0533  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C223(0.77); C230(0.77); C355(1.03); C364(1.03)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C223(0.77); C230(0.77); C355(1.05); C364(1.05)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C223(0.81); C230(0.81); C355(0.92); C364(0.92)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C223(0.88); C230(0.88); C355(0.98); C364(0.98)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C223(0.90); C230(0.90); C355(1.00); C364(1.00)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C223(1.03); C230(1.03); C355(0.98); C364(0.98)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C223(0.96); C230(0.96); C355(1.26); C364(1.26)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C223(0.76); C230(0.76); C355(1.15); C364(1.15)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C223(0.93); C230(0.93); C355(1.36); C364(1.36)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C223(0.63); C230(0.63); C355(1.10); C364(1.10)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C223(1.06); C230(1.06); C355(1.27); C364(1.27)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C223(0.74); C230(0.74); C355(1.28); C364(1.28)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C223(0.80); C230(0.80); C355(1.08); C364(1.08)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C223(0.90); C230(0.90)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C223(0.94); C230(0.94)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C223(0.99); C230(0.99)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C223(0.97); C230(0.97)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C223(1.04); C230(1.04)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C223(0.99); C230(0.99)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C223(1.03); C230(1.03)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C223(0.87); C230(0.87)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C223(0.89); C230(0.89)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C223(1.03); C230(1.03)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C223(0.74); C230(0.74)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C223(1.04); C230(1.04)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C223(0.87); C230(0.87)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C223(0.81); C230(0.81)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C223(0.89); C230(0.89)  LDD0562  [1]
 LDCM0276  AC17 HCT 116 C223(0.87); C230(0.87)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C223(0.88); C230(0.88)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C223(0.90); C230(0.90)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C223(0.70); C230(0.70)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C223(0.84); C230(0.84)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C223(0.81); C230(0.81)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C223(1.08); C230(1.08)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C223(0.97); C230(0.97)  LDD0601  [1]
 LDCM0320  AC57 HCT 116 C223(1.04); C230(1.04)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C223(0.90); C230(0.90)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C223(1.11); C230(1.11)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C223(1.10); C230(1.10)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C223(0.91); C230(0.91)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C223(1.02); C230(1.02)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C223(0.98); C230(0.98)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C223(1.07); C230(1.07)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C223(1.08); C230(1.08)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C223(0.95); C230(0.95)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C223(1.21); C230(1.21)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C223(1.06); C230(1.06)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C223(0.97); C230(0.97)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C223(1.87); C230(1.87)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C223(1.19); C230(1.19)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C223(1.13); C230(1.13)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C223(1.18); C230(1.18)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C223(1.50); C230(1.50)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C223(1.33); C230(1.33)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C223(1.14); C230(1.14)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C223(1.03); C230(1.03)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C223(0.79); C230(0.79)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C223(0.96); C230(0.96)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C223(1.27); C230(1.27)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C223(1.12); C230(1.12)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C223(1.38); C230(1.38)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C223(1.46); C230(1.46)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C223(1.58); C230(1.58)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C223(1.34); C230(1.34)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C223(1.22); C230(1.22)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C223(1.12); C230(1.12)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C223(1.12); C230(1.12)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C223(1.28); C230(1.28)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C223(1.01); C230(1.01)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C223(1.33); C230(1.33)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C223(1.30); C230(1.30)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C223(1.33); C230(1.33)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C223(1.37); C230(1.37)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C223(1.05); C230(1.05)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C223(1.28); C230(1.28)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C223(1.49); C230(1.49)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C355(1.13); C364(1.13); C223(1.14); C230(1.14)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C223(0.72); C230(0.72); C355(1.02); C364(1.02)  LDD0683  [1]
 LDCM0367  CL1 HCT 116 C355(1.23); C364(1.23)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C355(1.48); C364(1.48)  LDD0685  [1]
 LDCM0374  CL105 HCT 116 C223(0.89); C230(0.89)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C223(1.02); C230(1.02)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C223(0.84); C230(0.84)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C223(1.05); C230(1.05)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C223(1.09); C230(1.09)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C355(1.71); C364(1.71)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C223(1.18); C230(1.18)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C223(1.21); C230(1.21)  LDD0698  [1]
 LDCM0390  CL12 HCT 116 C355(1.85); C364(1.85)  LDD0707  [1]
 LDCM0396  CL125 HCT 116 C223(1.00); C230(1.00)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C223(1.01); C230(1.01)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C223(1.05); C230(1.05)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C223(1.05); C230(1.05)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C355(1.53); C364(1.53)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C355(1.34); C364(1.34)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C355(1.62); C364(1.62)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C355(1.14); C364(1.14)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C355(1.08); C364(1.08)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C355(1.04); C364(1.04)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C355(1.38); C364(1.38)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C355(1.55); C364(1.55)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C355(1.34); C364(1.34)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C355(1.64); C364(1.64)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C355(1.79); C364(1.79)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C355(1.05); C364(1.05)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C355(1.52); C364(1.52)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C355(1.33); C364(1.33)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C355(1.43); C364(1.43)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C355(1.51); C364(1.51)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C355(1.44); C364(1.44)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C355(1.20); C364(1.20)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C355(1.54); C364(1.54)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C355(1.20); C364(1.20)  LDD0736  [1]
 LDCM0429  CL4 HCT 116 C355(1.54); C364(1.54)  LDD0746  [1]
 LDCM0436  CL46 HCT 116 C355(1.05); C364(1.05)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C355(1.00); C364(1.00)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C355(0.98); C364(0.98)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C355(1.09); C364(1.09)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C355(1.49); C364(1.49)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C355(1.29); C364(1.29)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C355(0.96); C364(0.96)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C355(1.42); C364(1.42)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C355(1.39); C364(1.39)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C355(1.06); C364(1.06)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C355(1.16); C364(1.16)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C355(1.06); C364(1.06)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C355(1.17); C364(1.17)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C355(1.32); C364(1.32)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C355(1.14); C364(1.14)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C355(1.49); C364(1.49)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C355(1.06); C364(1.06)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C355(1.18); C364(1.18)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C355(1.45); C364(1.45)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C355(1.32); C364(1.32)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C355(1.43); C364(1.43)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C355(1.48); C364(1.48)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C355(1.47); C364(1.47)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C355(1.21); C364(1.21)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C355(1.49); C364(1.49)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C355(1.32); C364(1.32)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C355(1.61); C364(1.61)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C355(1.17); C364(1.17)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C355(1.39); C364(1.39)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C355(1.35); C364(1.35)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C355(1.36); C364(1.36)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C355(1.48); C364(1.48)  LDD0784  [1]
 LDCM0473  CL8 HCT 116 C355(1.24); C364(1.24)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C355(1.55); C364(1.55)  LDD0801  [1]
 LDCM0468  Fragment33 HCT 116 C355(1.41); C364(1.41)  LDD0785  [1]
 LDCM0022  KB02 CC-LP-1 C81(3.14)  LDD2298  [2]
 LDCM0023  KB03 CC-LP-1 C81(5.02)  LDD2715  [2]
 LDCM0024  KB05 SG231 C81(1.36)  LDD3418  [2]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840