Details of the Target

General Information of Target

Target ID LDTP13017
Target Name Zinc finger protein ZFAT (ZFAT)
Gene Name ZFAT
Gene ID 57623
Synonyms
KIAA1485; ZFAT1; ZNF406; Zinc finger protein ZFAT; Zinc finger gene in AITD susceptibility region; Zinc finger protein 406
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPHIQPF
KDEYEKFSGAYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQK
EITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVGDF
IRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFS
SRIECESPNNDLSRFRGFLEHSNKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKA
MLNNSGPRYKRSKLERRANTDVLWCVMLLVIMCLTGAVGHGIWLSRYEKMHFFNVPEPDG
HIISPLLAGFYMFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVDFYNEKMDSIVQC
RALNIAEDLGQIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENARRLESYQEAVSEDE
DFIDTVSGSLSNMAKPRAPSCRTVHNGPLGNKPSNHLAGSSFTLGSGEGASEVPHSRQAA
FSSPIETDVVPDTRLLDKFSQITPRLFMPLDETIQNPPMETLYIIDFFIALAICNTVVVS
APNQPRQKIRHPSLGGLPIKSLEEIKSLFQRWSVRRSSSPSLNSGKEPSSGVPNAFVSRL
PLFSRMKPASPVEEEVSQVCESPQCSSSSACCTETEKQHGDAGLLNGKAESLPGQPLACN
LCYEAESPDEAALVYAARAYQCTLRSRTPEQVMVDFAALGPLTFQLLHILPFDSVRKRMS
VVVRHPLSNQVVVYTKGADSVIMELLSVASPDGASLEKQQMIVREKTQKHLDDYAKQGLR
TLCIAKKVMSDTEYAEWLRNHFLAETSIDNREELLLESAMRLENKLTLLGATGIEDRLQE
GVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSKDACGMLMST
ILKELQKKTQALPEQVSLSEDLLQPPVPRDSGLRAGLIITGKTLEFALQESLQKQFLELT
SWCQAVVCCRATPLQKSEVVKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQ
AVMASDFAVSQFKHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGT
SMTDYWVLIFFNLLFTSAPPVIYGVLEKDVSAETLMQLPELYRSGQKSEAYLPHTFWITL
LDAFYQSLVCFFVPYFTYQGSDTDIFAFGNPLNTAALFIVLLHLVIESKSLTWIHLLVII
GSILSYFLFAIVFGAMCVTCNPPSNPYWIMQEHMLDPVFYLVCILTTSIALLPRFVYRVL
QGSLFPSPILRAKHFDRLTPEERTKALKKWRGAGKMNQVTSKYANQSAGKSGRRPMPGPS
AVFAMKSASSCAIEQGNLSLCETALDQGYSETKAFEMAGPSKGKES
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated.
Uniprot ID
Q9P243
Ensemble ID
ENST00000377838.8
HGNC ID
HGNC:19899

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A498 SNV: p.E7Ter .
BXPC3 SNV: p.L336Q .
CAL27 SNV: p.A976S .
COLO792 SNV: p.P670L .
DU145 SNV: p.P686H .
EFO27 SNV: p.K1076E .
HCT116 Deletion: p.L598CfsTer2
SNV: p.Y1091H		 .
HT115 SNV: p.V528A .
HUCCT1 SNV: p.V69A .
JHH7 SNV: p.K925R .
LS180 SNV: p.K725T; p.R867K .
MFE319 SNV: p.L1148I .
NCIH2286 SNV: p.K15E .
ONS76 SNV: p.S364A .
PC14 SNV: p.G740R .
PC9 SNV: p.G740R .
RKO SNV: p.E1206G .
SKMEL28 SNV: p.F326S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C434(1.11); C437(1.11)  LDD0547  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C392(1.01)  LDD1508  [2]
 LDCM0230  AC113 HCT 116 C434(1.11); C437(1.11)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C434(1.09); C437(1.09)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C434(1.30); C437(1.30)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C434(1.11); C437(1.11)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C434(0.82); C437(0.82)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C434(1.08); C437(1.08)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C434(1.34); C437(1.34)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C434(1.06); C437(1.06)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C434(1.00); C437(1.00)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C434(1.16); C437(1.16)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C434(1.42); C437(1.42)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C434(1.05); C437(1.05)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C434(1.20); C437(1.20)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C434(1.22); C437(1.22)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C434(0.89); C437(0.89)  LDD0562  [1]
 LDCM0276  AC17 HCT 116 C434(0.90); C437(0.90)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C434(0.95); C437(0.95)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C434(0.97); C437(0.97)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C392(1.12)  LDD1518  [2]
 LDCM0280  AC20 HCT 116 C434(1.10); C437(1.10)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C434(1.07); C437(1.07)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C434(0.89); C437(0.89)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C434(0.81); C437(0.81)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C434(0.90); C437(0.90)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C434(1.03); C437(1.03)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C434(1.00); C437(1.00)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C434(1.06); C437(1.06)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C434(1.02); C437(1.02)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C434(1.00); C437(1.00)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C434(1.05); C437(1.05)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C434(1.12); C437(1.12)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C434(1.14); C437(1.14)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C434(1.09); C437(1.09)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C434(1.10); C437(1.10)  LDD0612  [1]
 LDCM0302  AC40 HEK-293T C392(0.93)  LDD1541  [2]
 LDCM0304  AC42 HEK-293T C392(1.04)  LDD1543  [2]
 LDCM0310  AC48 HEK-293T C392(0.91)  LDD1549  [2]
 LDCM0313  AC50 HEK-293T C392(0.94)  LDD1552  [2]
 LDCM0319  AC56 HEK-293T C392(1.03)  LDD1558  [2]
 LDCM0321  AC58 HEK-293T C392(0.97)  LDD1560  [2]
 LDCM0328  AC64 HEK-293T C392(0.95)  LDD1567  [2]
 LDCM0332  AC68 HCT 116 C434(0.89); C437(0.89)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C434(0.80); C437(0.80)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C434(0.91); C437(0.91)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C434(1.00); C437(1.00)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C434(0.88); C437(0.88)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C434(0.88); C437(0.88)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C434(1.02); C437(1.02)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C434(1.06); C437(1.06)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C434(0.79); C437(0.79)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C434(0.95); C437(0.95)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C434(0.85); C437(0.85)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C434(0.91); C437(0.91)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C392(0.86)  LDD1569  [2]
 LDCM0346  AC80 HCT 116 C434(0.81); C437(0.81)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C434(1.07); C437(1.07)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C434(1.06); C437(1.06)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C434(1.11); C437(1.11)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C434(1.15); C437(1.15)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C434(1.04); C437(1.04)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C434(1.06); C437(1.06)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C434(1.00); C437(1.00)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C434(0.89); C437(0.89)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C434(1.05); C437(1.05)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C434(1.20); C437(1.20)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C434(1.06); C437(1.06)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C434(1.06); C437(1.06)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C434(0.93); C437(0.93)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C434(1.00); C437(1.00)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C434(0.91); C437(0.91)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C434(0.98); C437(0.98)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C434(0.89); C437(0.89)  LDD0681  [1]
 LDCM0275  AKOS034007705 HEK-293T C392(0.83)  LDD1514  [2]
 LDCM0369  CL100 HEK-293T C392(1.10)  LDD1573  [2]
 LDCM0373  CL104 HEK-293T C392(0.94)  LDD1577  [2]
 LDCM0374  CL105 HCT 116 C434(1.00); C437(1.00)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C434(1.33); C437(1.33)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C434(1.11); C437(1.11)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C434(1.19); C437(1.19)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C434(0.97); C437(0.97)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C434(1.07); C437(1.07)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C434(0.89); C437(0.89)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C434(0.94); C437(0.94)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C434(1.02); C437(1.02)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C434(0.87); C437(0.87)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C434(1.00); C437(1.00)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C434(1.08); C437(1.08)  LDD0703  [1]
 LDCM0390  CL12 HEK-293T C392(0.83)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C392(0.86)  LDD1595  [2]
 LDCM0395  CL124 HEK-293T C392(1.05)  LDD1599  [2]
 LDCM0399  CL128 HEK-293T C392(0.92)  LDD1603  [2]
 LDCM0403  CL16 HEK-293T C392(1.08)  LDD1607  [2]
 LDCM0405  CL18 HEK-293T C392(0.95)  LDD1609  [2]
 LDCM0412  CL24 HEK-293T C392(1.11)  LDD1616  [2]
 LDCM0416  CL28 HEK-293T C392(1.10)  LDD1620  [2]
 LDCM0419  CL30 HEK-293T C392(1.17)  LDD1623  [2]
 LDCM0425  CL36 HEK-293T C392(0.75)  LDD1629  [2]
 LDCM0429  CL4 HEK-293T C392(1.08)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C392(0.77)  LDD1634  [2]
 LDCM0432  CL42 HEK-293T C392(0.92)  LDD1636  [2]
 LDCM0438  CL48 HEK-293T C392(0.90)  LDD1642  [2]
 LDCM0443  CL52 HEK-293T C392(1.40)  LDD1646  [2]
 LDCM0445  CL54 HEK-293T C392(0.96)  LDD1648  [2]
 LDCM0451  CL6 HEK-293T C392(0.85)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C392(1.01)  LDD1655  [2]
 LDCM0453  CL61 HCT 116 C434(0.86); C437(0.86)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C434(1.31); C437(1.31)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C434(1.53); C437(1.53)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C434(1.77); C437(1.77)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C434(1.78); C437(1.78)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C434(1.87); C437(1.87)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C434(1.24); C437(1.24)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C434(1.09); C437(1.09)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C434(0.99); C437(0.99)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C434(1.54); C437(1.54)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C434(1.24); C437(1.24)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C434(1.18); C437(1.18)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C434(1.16); C437(1.16)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C434(1.54); C437(1.54)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C392(0.98)  LDD1672  [2]
 LDCM0471  CL78 HEK-293T C392(0.99)  LDD1674  [2]
 LDCM0478  CL84 HEK-293T C392(0.96)  LDD1681  [2]
 LDCM0482  CL88 HEK-293T C392(0.90)  LDD1685  [2]
 LDCM0485  CL90 HEK-293T C392(0.85)  LDD1688  [2]
 LDCM0491  CL96 HEK-293T C392(0.93)  LDD1694  [2]
 LDCM0468  Fragment33 HCT 116 C434(1.44); C437(1.44)  LDD0785  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402