Details of the Target

General Information of Target

Target ID LDTP12824
Target Name Homeobox protein Hox-C10 (HOXC10)
Gene Name HOXC10
Gene ID 3226
Synonyms
HOX3I; Homeobox protein Hox-C10; Homeobox protein Hox-3I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLAEERAALAAENADGEPGADRRLRLLGTYVAMSLRPAAGAWERCAGSAEAEQLLQAFL
GRDAAEGPRPLLVVRPGPRGLAIRPGLEVGPESGLAGAKALFFLRTGPEPPGPDSFRGAV
VCGDLPAAPLEHLAALFSEVVLPVLANEKNRLNWPHMICEDVRRHAHSLQCDLSVILEQV
KGKTLLPLPAGSEKMEFADSKSETVLDSIDKSVIYAIESAVIKWSYQVQVVLKRESSQPL
LQGENPTPKVELEFWKSRYEDLKYIYNQLRTITVRGMAKLLDKLQSSYFPAFKAMYRDVV
AALAEAQDIHVHLIPLQRHLEALENAEFPEVKPQLRPLLHVVCLIWATCKSYRSPGRLTV
LLQEICNLLIQQASNYLSPEDLLRSEVEESQRKLQVVSDTLSFFKQEFQDRRENLHTYFK
ENQEVKEWDFQSSLVFVRLDGFLGQLHVVEGLLKTALDFHKLGKVEFSGVRGNALSQQVQ
QMHEEFQEMYRLLSGSSSDCLYLQSTDFENDVSEFNQKVEDLDRRLGTIFIQAFDDAPGL
EHAFKLLDIAGNLLERPLVARDTSDKYLVLIQMFNKDLDAVRMIYSQHVQEEAELGFSPV
HKNMPTVAGGLRWAQELRQRIQGPFSNFGRITHPCMESAEGKRMQQKYEDMLSLLEKYET
RLYEDWCRTVSEKSQYNLSQPLLKRDPETKEITINFNPQLISVLKEMSYLEPREMKHMPE
TAAAMFSSRDFYRQLVANLELMANWYNKVMKTLLEVEFPLVEEELQNIDLRLRAAEETLN
WKTEGICDYVTEITSSIHDLEQRIQKTKDNVEEIQNIMKTWVTPIFKTKDGKRESLLSLD
DRHDRMEKYYNLIKESGLKIHALVQENLGLFSADPTSNIWKTYVNSIDNLLLNGFFLAIE
CSLKYLLENTECKAGLTPIFEAQLSLAIPELVFYPSLESGVKGGFCDIVEGLITSIFRIP
SLVPRLSPQNGSPHYQVDLDGIPDLANMRRTLMERVQRMMGLCCGYQSTFSQYSYLYVED
RKEVLGQFLLYGHILTPEEIEDHVEDGIPENPPLLSQFKVQIDSYETLYEEVCRLEPIKV
FDGWMKIDIRPFKASLLNIIKRWSLLFKQHLVDHVTHSLANLDAFIKKSESGLLKKVEKG
DFQGLVEIMGHLMAVKERQSNTDEMFEPLKQTIELLKTYEQELPETVFKQLEELPEKWNN
IKKVAITVKQQVAPLQANEVTLLRQRCTAFDAEQQQFWEQFHKEAPFRFDSIHPHQMLDA
RHIEIQQMESTMASISESASLFEVNVPDYKQLRQCRKEVCQLKELWDTIGMVTSSIHAWE
TTPWRNINVEAMELECKQFARHIRNLDKEVRAWDAFTGLESTVWNTLSSLRAVAELQNPA
IRERHWRQLMQATGVSFTMDQDTTLAHLLQLQLHHYEDEVRGIVDKAAKEMGMEKTLKEL
QTTWAGMEFQYEPHPRTNVPLLCSDEDLIEVLEDNQVQLQNLVMSKYVAFFLEEVSGWQK
KLSTVDAVISIWFEVQRTWTHLESIFTGSEDIRAQLPQDSKRFEGIDIDFKELAYDAQKI
PNVVQTTNKPGLYEKLEDIQGRLCLCEKALAEYLDTKRLAFPRFYFLSSSDLLDILSNGT
APQQVQRHLSKLFDNMAKMRFQLDASGEPTKTSLGMYSKEEEYVAFSEPCDCSGQVEIWL
NHVLGHMKATVRHEMTEGVTAYEEKPREQWLFDHPAQVALTCTQIWWTTEVGMAFARLEE
GYESAMKDYYKKQVAQLKTLITMLIGQLSKGDRQKIMTICTIDVHARDVVAKMIAQKVDN
AQAFLWLSQLRHRWDDEVKHCFANICDAQFLYSYEYLGNTPRLVITPLTDRCYITLTQSL
HLTMSGAPAGPAGTGKTETTKDLGRALGILVYVFNCSEQMDYKSCGNIYKGLAQTGAWGC
FDEFNRISVEVLSVVAVQVKSIQDAIRDKKQWFSFLGEEISLNPSVGIFITMNPGYAGRT
ELPENLKSLFRPCAMVVPDFELICEIMLVAEGFIEAQSLARKFITLYQLCKELLSKQDHY
DWGLRAIKSVLVVAGSLKRGDPDRPEDQVLMRSLRDFNIPKIVTDDMPIFMGLIGDLFPA
LDVPRRRDPNFEALVRKAIVDLKLQAEDNFVLKVVQLEELLAVRHSVFVVGGAGTGKSQV
LRSLHKTYQIMKRRPVWTDLNPKAVTNDELFGIINPATGEWKDGLFSSIMRELANITHDG
PKWILLDGDIDPMWIESLNTVMDDNKVLTLASNERIPLNPTMKLLFEISHLRTATPATVS
RAGILYINPADLGWNPPVSSWIEKREIQTERANLTILFDKYLPTCLDTLRTRFKKIIPIP
EQSMVQMVCHLLECLLTTEDIPADCPKEIYEHYFVFAAIWAFGGAMVQDQLVDYRAEFSK
WWLTEFKTVKFPSQGTIFDYYIDPETKKFEPWSKLVPQFEFDPEMPLQACLVHTSETIRV
CYFMERLMARQRPVMLVGTAGTGKSVLVGAKLASLDPEAYLVKNVPFNYYTTSAMLQAVL
EKPLEKKAGRNYGPPGNKKLIYFIDDMNMPEVDAYGTVQPHTIIRQHLDYGHWYDRSKLS
LKEITNVQYVSCMNPTAGSFTINPRLQRHFSVFVLSFPGADALSSIYSIILTQHLKLGNF
PASLQKSIPPLIDLALAFHQKIATTFLPTGIKFHYIFNLRDFANIFQGILFSSVECVKST
WDLIRLYLHESNRVYRDKMVEEKDFDLFDKIQTEVLKKTFDDIEDPVEQTQSPNLYCHFA
NGIGEPKYMPVQSWELLTQTLVEALENHNEVNTVMDLVLFEDAMRHVCHINRILESPRGN
ALLVGVGGSGKQSLTRLAAFISSMDVFQITLRKGYQIQDFKMDLASLCLKAGVKNLNTVF
LMTDAQVADERFLVLINDLLASGEIPDLYSDDEVENIISNVRNEVKSQGLVDNRENCWKF
FIDRIRRQLKVTLCFSPVGNKLRVRSRKFPAIVNCTAIHWFHEWPQQALESVSLRFLQNT
EGIEPTVKQSISKFMAFVHTSVNQTSQSYLSNEQRYNYTTPKSFLEFIRLYQSLLHRHRK
ELKCKTERLENGLLKLHSTSAQVDDLKAKLAAQEVELKQKNEDADKLIQVVGVETDKVSR
EKAMADEEEQKVAVIMLEVKQKQKDCEEDLAKAEPALTAAQAALNTLNKTNLTELKSFGS
PPLAVSNVSAAVMVLMAPRGRVPKDRSWKAAKVTMAKVDGFLDSLINFNKENIHENCLKA
IRPYLQDPEFNPEFVATKSYAAAGLCSWVINIVRFYEVFCDVEPKRQALNKATADLTAAQ
EKLAAIKAKIAHLNENLAKLTARFEKATADKLKCQQEAEVTAVTISLANRLVGGLASENV
RWADAVQNFKQQERTLCGDILLITAFISYLGFFTKKYRQSLLDRTWRPYLSQLKTPIPVT
PALDPLRMLMDDADVAAWQNEGLPADRMSVENATILINCERWPLMVDPQLQGIKWIKNKY
GEDLRVTQIGQKGYLQIIEQALEAGAVVLIENLEESIDPVLGPLLGREVIKKGRFIKIGD
KECEYNPKFRLILHTKLANPHYQPELQAQATLINFTVTRDGLEDQLLAAVVSMERPDLEQ
LKSDLTKQQNGFKITLKTLEDSLLSRLSSASGNFLGETVLVENLEITKQTAAEVEKKVQE
AKVTEVKINEAREHYRPAAARASLLYFIMNDLSKIHPMYQFSLKAFSIVFQKAVERAAPD
ESLRERVANLIDSITFSVYQYTIRGLFECDKLTYLAQLTFQILLMNREVNAVELDFLLRS
PVQTGTASPVEFLSHQAWGAVKVLSSMEEFSNLDRDIEGSAKSWKKFVESECPEKEKLPQ
EWKNKTALQRLCMLRAMRPDRMTYALRDFVEEKLGSKYVVGRALDFATSFEESGPATPMF
FILSPGVDPLKDVESQGRKLGYTFNNQNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQN
IHLVAKWLSTLEKKLEEHSENSHPEFRVFMSAEPAPSPEGHIIPQGILENSIKITNEPPT
GMHANLHKALDNFTQDTLEMCSRETEFKSILFALCYFHAVVAERRKFGPQGWNRSYPFNT
GDLTISVNVLYNFLEANAKVPYDDLRYLFGEIMYGGHITDDWDRRLCRTYLGEFIRPEML
EGELSLAPGFPLPGNMDYNGYHQYIDAELPPESPYLYGLHPNAEIGFLTQTSEKLFRTVL
ELQPRDSQARDGAGATREEKVKALLEEILERVTDEFNIPELMAKVEERTPYIVVAFQECG
RMNILTREIQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAW
FPDLLNRIKELEAWTGDFTMPSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQMALQCDM
TKKNREEFRSPPREGAYIHGLFMEGACWDTQAGIITEAKLKDLTPPMPVMFIKAIPADKQ
DCRSVYSCPVYKTSQRGPTYVWTFNLKTKENPSKWVLAGVALLLQI
Target Bioclass
Transcription factor
Family
Abd-B homeobox family
Subcellular location
Nucleus
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Uniprot ID
Q9NYD6
Ensemble ID
ENST00000303460.5
HGNC ID
HGNC:5122

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C111(1.12); C112(1.12)  LDD0078  [1]
IPM
 Probe Info  		N.A.  LDD0025  [2]
TFBX
 Probe Info  		C164(0.00); C47(0.00)  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C47(1.15)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C47(1.18)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C47(0.96)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C47(1.07)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C47(1.01)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C47(1.03)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C47(1.00)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C47(0.96)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C47(1.15)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C47(1.09)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C47(0.98)  LDD1519  [3]
 LDCM0282  AC22 HEK-293T C47(1.07)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C47(1.01)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C47(1.15)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C47(0.99)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C47(1.05)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C47(1.09)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C47(1.08)  LDD1527  [3]
 LDCM0290  AC3 HEK-293T C47(1.06)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C47(0.87)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C47(0.97)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C47(0.97)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C47(1.12)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C47(1.04)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C47(1.18)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C47(1.08)  LDD1536  [3]
 LDCM0299  AC38 HEK-293T C47(1.05)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C47(1.14)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C47(1.10)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C47(1.10)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C47(0.99)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C47(1.06)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C47(1.02)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C47(1.00)  LDD1545  [3]
 LDCM0308  AC46 HEK-293T C47(1.00)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C47(1.07)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C47(1.11)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C47(1.00)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C47(1.01)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C47(1.06)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C47(1.11)  LDD1554  [3]
 LDCM0317  AC54 HEK-293T C47(1.06)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C47(1.07)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C47(1.10)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C47(0.95)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C47(1.10)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C47(0.95)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C47(1.11)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C47(1.11)  LDD1563  [3]
 LDCM0326  AC62 HEK-293T C47(1.02)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C47(1.01)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C47(1.12)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C47(1.03)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C47(1.06)  LDD1569  [3]
 LDCM0356  AKOS034007680 HEK-293T C47(0.86)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C47(1.06)  LDD1514  [3]
 LDCM0020  ARS-1620 HCC44 C111(1.12); C112(1.12)  LDD0078  [1]
 LDCM0368  CL10 HEK-293T C47(0.97)  LDD1572  [3]
 LDCM0379  CL11 HEK-293T C47(1.03)  LDD1583  [3]
 LDCM0390  CL12 HEK-293T C47(1.03)  LDD1594  [3]
 LDCM0404  CL17 HEK-293T C47(1.03)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C47(1.15)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C47(1.02)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C47(1.14)  LDD1612  [3]
 LDCM0410  CL22 HEK-293T C47(1.03)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C47(1.08)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C47(1.06)  LDD1616  [3]
 LDCM0417  CL29 HEK-293T C47(0.97)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C47(1.12)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C47(0.97)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C47(1.15)  LDD1625  [3]
 LDCM0423  CL34 HEK-293T C47(0.91)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C47(1.06)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C47(1.09)  LDD1629  [3]
 LDCM0431  CL41 HEK-293T C47(0.88)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C47(1.16)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C47(1.02)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C47(1.17)  LDD1638  [3]
 LDCM0436  CL46 HEK-293T C47(0.98)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C47(1.06)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C47(1.24)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C47(0.95)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C47(0.93)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C47(1.04)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C47(0.97)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C47(1.07)  LDD1650  [3]
 LDCM0449  CL58 HEK-293T C47(1.11)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C47(1.04)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C47(1.01)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C47(1.31)  LDD1655  [3]
 LDCM0457  CL65 HEK-293T C47(0.97)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C47(1.13)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C47(1.05)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C47(1.10)  LDD1663  [3]
 LDCM0462  CL7 HEK-293T C47(1.02)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C47(1.17)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C47(0.99)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C47(1.13)  LDD1668  [3]
 LDCM0470  CL77 HEK-293T C47(0.99)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C47(1.11)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C47(1.11)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C47(1.00)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C47(1.04)  LDD1677  [3]
 LDCM0476  CL82 HEK-293T C47(1.00)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C47(1.02)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C47(1.05)  LDD1681  [3]
 LDCM0483  CL89 HEK-293T C47(1.06)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C47(0.97)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C47(1.06)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C47(1.22)  LDD1690  [3]
 LDCM0489  CL94 HEK-293T C47(1.12)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C47(1.18)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C47(1.02)  LDD1694  [3]
 LDCM0022  KB02 A-375 C47(3.77)  LDD2255  [4]
 LDCM0023  KB03 A-375 C47(4.18)  LDD2672  [4]
 LDCM0024  KB05 NCI-H1155 C47(4.25)  LDD3342  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 21 (USP21) Peptidase C19 family Q9UK80

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840