Details of the Target

General Information of Target

Target ID LDTP12618
Target Name TBC1 domain family member 22B (TBC1D22B)
Gene Name TBC1D22B
Gene ID 55633
Synonyms
C6orf197; TBC1 domain family member 22B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNAGPSWNKVQHSKNSSGKRQSKSQVPHASSQPRSSLTAVTQPTEEKLKESISPEARRKR
NPLGSRCQGASGNKLFLDFQSMKIIKENADEDSASDLSDSERIPIPPSPLTPPDLNLRAE
EIDPVYFDLHPGQGHTKPEYYYPNFLPSPFSSWDLRDMALLLNAENKTEAVPRVGGLLGK
YIDRLIQLEWLQVQTVQCEKAKGGKARPPTAPGTSGALKSPGRSKLIASALSKPLPHQEG
ASKSGPSRKKAFHHEEIHPSHYAFETSPRPIDVLGGTRFCSQRQTLEMRTEEKKKKSSKS
TKLQRWDLSGSGSSSKVETSGHIRVPKQAAVILDSADSCKASKTQAHAHPRKKGKAESCG
HATVSSEKKLKTNGVKQNTYKLK
Target Bioclass
Other
Function May act as a GTPase-activating protein for Rab family protein(s).
Uniprot ID
Q9NU19
Ensemble ID
ENST00000373491.3
HGNC ID
HGNC:21602

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K106(6.61)  LDD0277  [1]
AZ-9
 Probe Info  		E382(0.96)  LDD2208  [2]
BTD
 Probe Info  		C144(0.95)  LDD2117  [3]
DBIA
 Probe Info  		C144(102.19)  LDD0209  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C144(0.95)  LDD2117  [3]
 LDCM0281  AC21 HEK-293T C206(0.96)  LDD1520  [8]
 LDCM0284  AC24 HEK-293T C206(1.10)  LDD1523  [8]
 LDCM0289  AC29 HEK-293T C206(1.01)  LDD1528  [8]
 LDCM0293  AC32 HEK-293T C206(0.96)  LDD1532  [8]
 LDCM0296  AC35 PaTu 8988t C206(0.95)  LDD1175  [9]
 LDCM0297  AC36 PaTu 8988t C206(0.80)  LDD1176  [9]
 LDCM0298  AC37 PaTu 8988t C206(1.32)  LDD1177  [9]
 LDCM0299  AC38 PaTu 8988t C206(1.03)  LDD1178  [9]
 LDCM0300  AC39 PaTu 8988t C206(0.80)  LDD1179  [9]
 LDCM0302  AC40 PaTu 8988t C206(0.82)  LDD1181  [9]
 LDCM0303  AC41 PaTu 8988t C206(0.90)  LDD1182  [9]
 LDCM0304  AC42 PaTu 8988t C206(0.98)  LDD1183  [9]
 LDCM0305  AC43 PaTu 8988t C206(1.11)  LDD1184  [9]
 LDCM0306  AC44 PaTu 8988t C206(1.17)  LDD1185  [9]
 LDCM0307  AC45 PaTu 8988t C206(1.12)  LDD1186  [9]
 LDCM0310  AC48 HEK-293T C206(1.14)  LDD1549  [8]
 LDCM0312  AC5 HEK-293T C206(1.09)  LDD1551  [8]
 LDCM0316  AC53 HEK-293T C206(1.08)  LDD1555  [8]
 LDCM0319  AC56 HEK-293T C206(1.13)  LDD1558  [8]
 LDCM0325  AC61 HEK-293T C206(1.10)  LDD1564  [8]
 LDCM0328  AC64 HEK-293T C206(1.02)  LDD1567  [8]
 LDCM0345  AC8 HEK-293T C206(1.15)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C206(1.02)  LDD1511  [8]
 LDCM0275  AKOS034007705 HEK-293T C206(1.12)  LDD1514  [8]
 LDCM0367  CL1 PaTu 8988t C206(1.20)  LDD1246  [9]
 LDCM0368  CL10 PaTu 8988t C206(1.17)  LDD1247  [9]
 LDCM0371  CL102 HEK-293T C354(0.85)  LDD1575  [8]
 LDCM0375  CL106 HEK-293T C354(0.90)  LDD1579  [8]
 LDCM0379  CL11 PaTu 8988t C206(1.13)  LDD1258  [9]
 LDCM0380  CL110 HEK-293T C354(0.76)  LDD1584  [8]
 LDCM0384  CL114 HEK-293T C354(0.75)  LDD1588  [8]
 LDCM0387  CL117 PaTu 8988t C206(0.96)  LDD1266  [9]
 LDCM0388  CL118 PaTu 8988t C206(1.14)  LDD1267  [9]
 LDCM0389  CL119 PaTu 8988t C206(0.79)  LDD1268  [9]
 LDCM0390  CL12 PaTu 8988t C206(0.92)  LDD1269  [9]
 LDCM0391  CL120 PaTu 8988t C206(0.98)  LDD1270  [9]
 LDCM0393  CL122 HEK-293T C354(0.90)  LDD1597  [8]
 LDCM0397  CL126 HEK-293T C354(0.75)  LDD1601  [8]
 LDCM0400  CL13 PaTu 8988t C206(1.27)  LDD1279  [9]
 LDCM0401  CL14 PaTu 8988t C206(1.07)  LDD1280  [9]
 LDCM0402  CL15 PaTu 8988t C206(0.76)  LDD1281  [9]
 LDCM0407  CL2 PaTu 8988t C206(0.87)  LDD1286  [9]
 LDCM0409  CL21 HEK-293T C206(0.98)  LDD1613  [8]
 LDCM0412  CL24 HEK-293T C206(1.03)  LDD1616  [8]
 LDCM0414  CL26 HEK-293T C354(0.97)  LDD1618  [8]
 LDCM0418  CL3 PaTu 8988t C206(0.93)  LDD1297  [9]
 LDCM0420  CL31 PaTu 8988t C206(1.02)  LDD1299  [9]
 LDCM0421  CL32 PaTu 8988t C206(0.82)  LDD1300  [9]
 LDCM0422  CL33 PaTu 8988t C206(0.80)  LDD1301  [9]
 LDCM0423  CL34 PaTu 8988t C206(0.79)  LDD1302  [9]
 LDCM0424  CL35 PaTu 8988t C206(0.83)  LDD1303  [9]
 LDCM0425  CL36 PaTu 8988t C206(0.49)  LDD1304  [9]
 LDCM0426  CL37 PaTu 8988t C206(1.08)  LDD1305  [9]
 LDCM0428  CL39 PaTu 8988t C206(1.30)  LDD1307  [9]
 LDCM0429  CL4 PaTu 8988t C206(0.84)  LDD1308  [9]
 LDCM0430  CL40 PaTu 8988t C206(0.77)  LDD1309  [9]
 LDCM0431  CL41 PaTu 8988t C206(0.97)  LDD1310  [9]
 LDCM0432  CL42 PaTu 8988t C206(0.92)  LDD1311  [9]
 LDCM0433  CL43 PaTu 8988t C206(1.00)  LDD1312  [9]
 LDCM0434  CL44 PaTu 8988t C206(0.91)  LDD1313  [9]
 LDCM0435  CL45 PaTu 8988t C206(0.74)  LDD1314  [9]
 LDCM0438  CL48 HEK-293T C206(1.05)  LDD1642  [8]
 LDCM0440  CL5 PaTu 8988t C206(1.37)  LDD1319  [9]
 LDCM0441  CL50 HEK-293T C354(1.22)  LDD1645  [8]
 LDCM0448  CL57 HEK-293T C206(1.04)  LDD1651  [8]
 LDCM0451  CL6 PaTu 8988t C206(0.96)  LDD1330  [9]
 LDCM0452  CL60 HEK-293T C206(1.08)  LDD1655  [8]
 LDCM0453  CL61 PaTu 8988t C206(1.13)  LDD1332  [9]
 LDCM0454  CL62 PaTu 8988t C206(1.18)  LDD1333  [9]
 LDCM0455  CL63 PaTu 8988t C206(1.18)  LDD1334  [9]
 LDCM0456  CL64 PaTu 8988t C206(1.34)  LDD1335  [9]
 LDCM0457  CL65 PaTu 8988t C206(1.22)  LDD1336  [9]
 LDCM0458  CL66 PaTu 8988t C206(1.26)  LDD1337  [9]
 LDCM0459  CL67 PaTu 8988t C206(1.29)  LDD1338  [9]
 LDCM0460  CL68 PaTu 8988t C206(1.56)  LDD1339  [9]
 LDCM0461  CL69 PaTu 8988t C206(1.37)  LDD1340  [9]
 LDCM0462  CL7 PaTu 8988t C206(1.01)  LDD1341  [9]
 LDCM0463  CL70 PaTu 8988t C206(1.53)  LDD1342  [9]
 LDCM0464  CL71 PaTu 8988t C206(1.32)  LDD1343  [9]
 LDCM0465  CL72 PaTu 8988t C206(1.43)  LDD1344  [9]
 LDCM0466  CL73 PaTu 8988t C206(1.32)  LDD1345  [9]
 LDCM0467  CL74 PaTu 8988t C206(1.22)  LDD1346  [9]
 LDCM0473  CL8 PaTu 8988t C206(0.94)  LDD1352  [9]
 LDCM0475  CL81 HEK-293T C206(0.98)  LDD1678  [8]
 LDCM0478  CL84 HEK-293T C206(0.98)  LDD1681  [8]
 LDCM0480  CL86 HEK-293T C354(0.89)  LDD1683  [8]
 LDCM0484  CL9 PaTu 8988t C206(1.10)  LDD1363  [9]
 LDCM0488  CL93 HEK-293T C206(1.13)  LDD1691  [8]
 LDCM0491  CL96 HEK-293T C206(1.06)  LDD1694  [8]
 LDCM0493  CL98 HEK-293T C354(0.91)  LDD1696  [8]
 LDCM0625  F8 Ramos C144(1.27)  LDD2187  [10]
 LDCM0573  Fragment11 Ramos C144(15.92)  LDD2190  [10]
 LDCM0575  Fragment13 Ramos C144(0.84)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C144(0.93)  LDD2193  [10]
 LDCM0582  Fragment23 Ramos C144(1.59)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C144(0.93)  LDD2197  [10]
 LDCM0589  Fragment31 Ramos C144(0.87)  LDD2200  [10]
 LDCM0468  Fragment33 PaTu 8988t C206(1.37)  LDD1347  [9]
 LDCM0596  Fragment38 Ramos C144(1.24)  LDD2203  [10]
 LDCM0427  Fragment51 PaTu 8988t C206(0.82)  LDD1306  [9]
 LDCM0614  Fragment56 Ramos C144(0.86)  LDD2205  [10]
 LDCM0023  KB03 Jurkat C144(102.19)  LDD0209  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Golgi resident protein GCP60 (ACBD3) . Q9H3P7
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Zinc finger protein 90 homolog (ZFP90) Krueppel C2H2-type zinc-finger protein family Q8TF47
Golgin-45 (BLZF1) . Q9H2G9
High mobility group protein 20A (HMG20A) . Q9NP66
LIM/homeobox protein Lhx8 (LHX8) . Q68G74
Zinc finger and SCAN domain-containing protein 4 (ZSCAN4) . Q8NAM6
Other
Click To Hide/Show 30 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Coiled-coil domain-containing protein 88B (CCDC88B) CCDC88 family A6NC98
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
RNA-binding protein 48 (RBM48) RBM48 family Q5RL73
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
Spermatogenesis-associated protein 2 (SPATA2) SPATA2 family Q9UM82
Testis-expressed protein 11 (TEX11) SPO22 family Q8IYF3
Transforming acidic coiled-coil-containing protein 3 (TACC3) TACC family Q9Y6A5
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Four and a half LIM domains protein 3 (FHL3) . Q13643
PRKCA-binding protein (PICK1) . Q9NRD5
Puratrophin-1 (PLEKHG4) . Q58EX7
Rho guanine nucleotide exchange factor 9 (ARHGEF9) . O43307
RNA-binding protein 10 (RBM10) . P98175
Vinexin (SORBS3) . O60504

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578