Details of the Target

General Information of Target

Target ID LDTP12479
Target Name Delta-like protein 4 (DLL4)
Gene Name DLL4
Gene ID 54567
Synonyms
Delta-like protein 4; Drosophila Delta homolog 4; Delta4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAVSVTPIRDTKWLTLEVCREFQRGTCSRPDTECKFAHPSKSCQVENGRVIACFDSLKGR
CSRENCKYLHPPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSV
APSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKLMRTD
RLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPP
AHLQAKIKAAQYQVNQAAAAQAAATAAAMTQSAVKSLKRPLEATFDLGIPQAVLPPLPKR
PALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPVPMVHGATPATVSAATTSATSV
PFAATATANQIPIISAEHLTSHKYVTQM
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.
TTD ID
T55273
Uniprot ID
Q9NR61
DrugMap ID
TTV23LH
Ensemble ID
ENST00000249749.7
HGNC ID
HGNC:2910
ChEMBL ID
CHEMBL3712916

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C653(1.32)  LDD3380  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C653(1.06)  LDD1507  [3]
 LDCM0237  AC12 HEK-293T C653(1.09); C310(0.77); C312(0.77)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C653(1.04); C310(0.90); C312(0.90)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C653(0.88)  LDD1515  [3]
 LDCM0280  AC20 HEK-293T C653(0.99); C310(0.95); C312(0.95)  LDD1519  [3]
 LDCM0283  AC23 HEK-293T C653(0.99); C310(0.86); C312(0.86)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C653(0.90)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C653(0.93)  LDD1524  [3]
 LDCM0288  AC28 HEK-293T C653(1.03); C310(0.87); C312(0.87)  LDD1527  [3]
 LDCM0292  AC31 HEK-293T C653(1.10); C310(0.92); C312(0.92)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C653(0.90)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C653(1.09)  LDD1533  [3]
 LDCM0297  AC36 HEK-293T C653(1.03); C310(0.93); C312(0.93)  LDD1536  [3]
 LDCM0300  AC39 HEK-293T C653(0.94); C310(0.76); C312(0.76)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C653(1.10); C310(0.79); C312(0.79)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C653(0.90)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C653(1.27)  LDD1542  [3]
 LDCM0306  AC44 HEK-293T C653(1.09); C310(0.70); C312(0.70)  LDD1545  [3]
 LDCM0309  AC47 HEK-293T C653(1.01); C310(0.86); C312(0.86)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C653(0.88)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C653(1.11)  LDD1550  [3]
 LDCM0315  AC52 HEK-293T C653(1.02); C310(0.78); C312(0.78)  LDD1554  [3]
 LDCM0318  AC55 HEK-293T C653(1.02); C310(0.88); C312(0.88)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C653(0.92)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C653(1.22)  LDD1559  [3]
 LDCM0324  AC60 HEK-293T C653(0.99); C310(1.04); C312(1.04)  LDD1563  [3]
 LDCM0327  AC63 HEK-293T C653(1.07); C310(0.80); C312(0.80)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C653(0.94)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C653(0.93); C310(0.85); C312(0.85)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C653(0.86)  LDD1569  [3]
 LDCM0356  AKOS034007680 HEK-293T C653(1.07)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C653(1.03)  LDD1514  [3]
 LDCM0369  CL100 HEK-293T C653(1.00)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C653(1.12)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C653(1.11); C310(0.70); C312(0.70)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C653(1.17)  LDD1577  [3]
 LDCM0375  CL106 HEK-293T C653(0.92)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C653(0.87); C310(0.83); C312(0.83)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C653(0.98)  LDD1581  [3]
 LDCM0379  CL11 HEK-293T C653(1.18); C310(0.94); C312(0.94)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C653(0.94)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C653(0.97); C310(0.70); C312(0.70)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C653(0.99)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C653(1.21)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C653(1.07); C310(0.77); C312(0.77)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C653(1.02)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C653(1.04)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C653(1.12); C310(1.03); C312(1.03)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C653(0.97)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C653(1.06)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C653(1.06)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C653(1.10); C310(0.61); C312(0.61)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C653(1.01)  LDD1599  [3]
 LDCM0397  CL126 HEK-293T C653(1.08)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C653(1.07); C310(0.73); C312(0.73)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C653(1.05)  LDD1603  [3]
 LDCM0401  CL14 HEK-293T C653(0.82)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C653(1.29); C310(0.88); C312(0.88)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C653(1.08)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C653(1.38)  LDD1608  [3]
 LDCM0407  CL2 HEK-293T C653(0.95)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C653(1.15); C310(1.13); C312(1.13)  LDD1612  [3]
 LDCM0411  CL23 HEK-293T C653(1.17); C310(1.03); C312(1.03)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C653(1.01)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C653(0.87)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C653(0.98); C310(0.88); C312(0.88)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C653(1.07)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C653(0.97)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C653(1.04); C310(0.76); C312(0.76)  LDD1622  [3]
 LDCM0421  CL32 HEK-293T C653(1.07); C310(0.93); C312(0.93)  LDD1625  [3]
 LDCM0424  CL35 HEK-293T C653(1.00); C310(0.90); C312(0.90)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C653(0.97)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C653(1.07); C310(0.93); C312(0.93)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C653(1.13)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C653(0.96)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C653(1.02)  LDD1635  [3]
 LDCM0434  CL44 HEK-293T C653(0.97); C310(0.86); C312(0.86)  LDD1638  [3]
 LDCM0437  CL47 HEK-293T C653(1.08); C310(1.12); C312(1.12)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C653(0.92)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C653(1.08)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C653(1.20)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C653(1.09)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C653(1.34)  LDD1647  [3]
 LDCM0447  CL56 HEK-293T C653(1.05); C310(1.02); C312(1.02)  LDD1650  [3]
 LDCM0450  CL59 HEK-293T C653(1.14); C310(0.91); C312(0.91)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C653(0.97)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C653(1.04)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C653(1.05); C310(0.73); C312(0.73)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C653(1.21)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C653(1.10)  LDD1660  [3]
 LDCM0460  CL68 HEK-293T C653(1.12); C310(1.11); C312(1.11)  LDD1663  [3]
 LDCM0464  CL71 HEK-293T C653(1.11); C310(0.93); C312(0.93)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C653(0.94)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C653(0.90)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C653(0.98)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C653(1.39)  LDD1673  [3]
 LDCM0473  CL8 HEK-293T C653(1.58); C310(0.93); C312(0.93)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C653(1.05); C310(0.80); C312(0.80)  LDD1677  [3]
 LDCM0477  CL83 HEK-293T C653(1.03); C310(1.01); C312(1.01)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C653(1.01)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C653(0.98)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C653(1.07); C310(0.65); C312(0.65)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C653(1.09)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C653(1.12)  LDD1686  [3]
 LDCM0487  CL92 HEK-293T C653(1.27); C310(1.02); C312(1.02)  LDD1690  [3]
 LDCM0490  CL95 HEK-293T C653(1.36); C310(0.84); C312(0.84)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C653(1.02)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C653(0.74)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C653(0.92); C310(0.55); C312(0.55)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C653(1.09); C310(0.83); C312(0.83)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C653(1.04); C310(0.64); C312(0.64)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C653(1.02)  LDD1631  [3]
 LDCM0022  KB02 FU-OV-1 C653(1.36)  LDD2328  [1]
 LDCM0023  KB03 A2780 C653(1.34)  LDD2671  [1]
 LDCM0024  KB05 OV-90 C653(1.32)  LDD3380  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Synaptojanin-2-binding protein (SYNJ2BP) . P57105

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dilpacimab Antibody DMEV15
Phase 1
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nov1501 Antibody DIPY14
Regn-421 Antibody D06VCC
Abt-165 . D0PP6A
Navicixizumab . D00IVN
Omp-21m18 . D0GS9X

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402