Details of the Target

General Information of Target

Target ID LDTP12231
Target Name Protein TANC2 (TANC2)
Gene Name TANC2
Gene ID 26115
Synonyms
KIAA1148; KIAA1636; Protein TANC2; Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNTAPSRPSPTRRDPYGFGDSRDSRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRDL
RDHRHSRDLRDHRDSRSVRDVRDVRDLRDFRDLRDSRDFRDQRDPMYDRYRDMRDSRDPM
YRREGSYDRYLRMDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREEL
YRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQ
ALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNE
CREKEREEIARQAAKMADEAILQERERGGPEEGVRGGHPPAIQSLINLLADNRYLTAEET
DKIINYLRERKERLMRSSTDSLPGPISRQPLGATSGASLKTQPSSQPLQSGQVLPSATPT
PSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQAS
GNQPPSILGQGGSAQNMGPRPGAPSQGLFGQPSSRLAPASNMTSQRPVSSTGINFDNPSV
QKALDTLIQSGPALSHLVSQTTAQMGQPQAPMGSYQRHY
Target Bioclass
Other
Family
TANC family
Subcellular location
Cell projection, dendritic spine
Function Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines.
Uniprot ID
Q9HCD6
Ensemble ID
ENST00000389520.8
HGNC ID
HGNC:30212

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.12  LDD0402  [1]
STPyne
 Probe Info  		K1272(0.19); K7(10.00)  LDD0277  [2]
DBIA
 Probe Info  		C1365(1.97)  LDD3352  [3]
IA-alkyne
 Probe Info  		C1050(0.00); C1372(0.00); C507(0.00)  LDD0162  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		C1820(0.00); C1729(0.00)  LDD0147  [6]
TFBX
 Probe Info  		C1372(0.00); C1050(0.00); C1729(0.00)  LDD0148  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		9.30  LDD0443  [8]
NAIA_5
 Probe Info  		C388(0.00); C507(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C953(0.93)  LDD1508  [9]
 LDCM0237  AC12 HEK-293T C162(0.91)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C162(1.16)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C162(1.39)  LDD1513  [9]
 LDCM0277  AC18 HEK-293T C953(1.08)  LDD1516  [9]
 LDCM0279  AC2 HEK-293T C953(1.05)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C162(0.94)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C162(1.01)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C162(0.94)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C162(1.33)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C162(0.88); C1729(0.99)  LDD1523  [9]
 LDCM0286  AC26 HEK-293T C953(0.92)  LDD1525  [9]
 LDCM0288  AC28 HEK-293T C162(1.00)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C162(1.00)  LDD1528  [9]
 LDCM0291  AC30 HEK-293T C162(1.42)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C162(1.43)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C162(0.87); C1729(1.15)  LDD1532  [9]
 LDCM0295  AC34 HEK-293T C953(0.99)  LDD1534  [9]
 LDCM0297  AC36 HEK-293T C162(1.11)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C162(0.99)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C162(1.36)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C162(1.47)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C162(1.05)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C162(1.20); C1729(1.18)  LDD1541  [9]
 LDCM0304  AC42 HEK-293T C953(1.00)  LDD1543  [9]
 LDCM0306  AC44 HEK-293T C162(0.89)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C162(1.28)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C162(0.99)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C162(1.35)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C162(1.29); C1729(1.22)  LDD1549  [9]
 LDCM0312  AC5 HEK-293T C162(1.10)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C953(1.00)  LDD1552  [9]
 LDCM0315  AC52 HEK-293T C162(0.87)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C162(0.95)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C162(1.47)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C162(1.21)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C162(1.10); C1729(1.13)  LDD1558  [9]
 LDCM0321  AC58 HEK-293T C953(0.96)  LDD1560  [9]
 LDCM0323  AC6 HEK-293T C162(1.16)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C162(1.37)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C162(1.34)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C162(1.34)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C162(1.24)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C162(0.92); C1729(1.16)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C162(1.10)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C162(1.16); C1729(1.02)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C162(1.05)  LDD1511  [9]
 LDCM0275  AKOS034007705 HEK-293T C162(1.33); C1729(1.15)  LDD1514  [9]
 LDCM0632  CL-Sc Hep-G2 C388(1.37)  LDD2227  [5]
 LDCM0368  CL10 HEK-293T C162(1.24)  LDD1572  [9]
 LDCM0372  CL103 HEK-293T C162(0.81)  LDD1576  [9]
 LDCM0376  CL107 HEK-293T C162(0.69)  LDD1580  [9]
 LDCM0379  CL11 HEK-293T C162(1.66)  LDD1583  [9]
 LDCM0381  CL111 HEK-293T C162(1.40)  LDD1585  [9]
 LDCM0385  CL115 HEK-293T C162(1.04)  LDD1589  [9]
 LDCM0389  CL119 HEK-293T C162(1.10)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C162(1.19); C1729(0.94)  LDD1594  [9]
 LDCM0394  CL123 HEK-293T C162(0.88)  LDD1598  [9]
 LDCM0398  CL127 HEK-293T C162(0.90)  LDD1602  [9]
 LDCM0402  CL15 HEK-293T C162(1.03)  LDD1606  [9]
 LDCM0405  CL18 HEK-293T C953(1.18)  LDD1609  [9]
 LDCM0408  CL20 HEK-293T C162(1.18)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C162(2.51)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C162(1.79)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C162(1.48)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C162(1.27); C1729(0.85)  LDD1616  [9]
 LDCM0415  CL27 HEK-293T C162(0.84)  LDD1619  [9]
 LDCM0418  CL3 HEK-293T C162(0.69)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C953(0.93)  LDD1623  [9]
 LDCM0421  CL32 HEK-293T C162(1.08)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C162(1.69)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C162(1.19)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C162(1.35)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C162(0.90); C1729(0.87)  LDD1629  [9]
 LDCM0428  CL39 HEK-293T C162(0.69)  LDD1632  [9]
 LDCM0432  CL42 HEK-293T C953(1.17)  LDD1636  [9]
 LDCM0434  CL44 HEK-293T C162(0.97)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C162(2.22)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C162(1.13)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C162(1.52)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C162(1.06); C1729(0.83)  LDD1642  [9]
 LDCM0445  CL54 HEK-293T C953(1.08)  LDD1648  [9]
 LDCM0447  CL56 HEK-293T C162(1.45)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C162(2.55)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C162(1.26)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C162(1.27)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C953(1.06)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C162(0.92); C1729(0.92)  LDD1655  [9]
 LDCM0455  CL63 HEK-293T C162(0.91)  LDD1658  [9]
 LDCM0458  CL66 HEK-293T C953(1.05)  LDD1661  [9]
 LDCM0460  CL68 HEK-293T C162(0.94)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C162(1.92)  LDD1664  [9]
 LDCM0463  CL70 HEK-293T C162(1.17)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C162(1.91)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C162(0.82); C1729(0.97)  LDD1668  [9]
 LDCM0471  CL78 HEK-293T C953(1.09)  LDD1674  [9]
 LDCM0473  CL8 HEK-293T C162(1.06)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C162(0.99)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C162(2.13)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C162(1.77)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C162(1.19)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C162(0.94); C1729(1.20)  LDD1681  [9]
 LDCM0481  CL87 HEK-293T C162(0.92)  LDD1684  [9]
 LDCM0484  CL9 HEK-293T C162(2.06)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C953(1.03)  LDD1688  [9]
 LDCM0487  CL92 HEK-293T C162(1.22)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C162(1.81)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C162(1.41)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C162(1.21)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C162(0.87); C1729(0.91)  LDD1694  [9]
 LDCM0494  CL99 HEK-293T C162(0.96)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C162(1.02)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C162(0.80)  LDD1671  [9]
 LDCM0022  KB02 HEK-293T C162(0.77)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C162(1.11)  LDD1497  [9]
 LDCM0024  KB05 NCI-H1975 C1365(1.97)  LDD3352  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402