Details of the Target

General Information of Target

Target ID LDTP11962
Target Name Zinc finger protein Pegasus (IKZF5)
Gene Name IKZF5
Gene ID 64376
Synonyms
ZNFN1A5; Zinc finger protein Pegasus; Ikaros family zinc finger protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASRNGFEAVEAEGSAGCRGSSGMEVVLPLDPAVPAPLCPHGPTLLFVKVTQGKEETRR
FYACSACRDRKDCNFFQWEDEKLSGARLAAREAHNRRCQPPLSRTQCVERYLKFIELPLT
QRKFCQTCQQLLLPDDWGQHSEHQVLGNVSITQLRRPSQLLYPLENKKTNAQYLFADRSC
QFLVDLLSALGFRRVLCVGTPRLHELIKLTASGDKKSNIKSLLLDIDFRYSQFYMEDSFC
HYNMFNHHFFDGKTALEVCRAFLQEDKGEGIIMVTDPPFGGLVEPLAITFKKLIAMWKEG
QSQDDSHKELPIFWIFPYFFESRICQFFPSFQMLDYQVDYDNHALYKHGKTGRKQSPVRI
FTNIPPNKIILPTEEGYRFCSPCQRYVSLENQHCELCNSCTSKDGRKWNHCFLCKKCVKP
SWIHCSICNHCAVPDHSCEGPKHGCFICGELDHKRSTCPNIATSKRANKAVRKQKQRKSN
KMKMETTKGQSMNHTSATRRKKRRERAHQYLGS
Target Bioclass
Transcription factor
Family
Ikaros C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence. Involved in megakaryocyte differentiation.
Uniprot ID
Q9H5V7
Ensemble ID
ENST00000368886.10
HGNC ID
HGNC:14283

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C409(0.99)  LDD1702  [1]
DBIA
 Probe Info  		C140(1.02); C143(1.02)  LDD0547  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HCT 116 C140(1.02); C143(1.02)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C140(0.95); C143(0.95)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C140(1.16); C143(1.16)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C140(1.21); C143(1.21)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C140(1.17); C143(1.17)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C140(1.12); C143(1.12)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C140(1.24); C143(1.24)  LDD0553  [2]
 LDCM0238  AC120 HCT 116 C140(1.02); C143(1.02)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C140(0.87); C143(0.87)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C140(0.97); C143(0.97)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C140(0.85); C143(0.85)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C140(1.26); C143(1.26)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C140(1.02); C143(1.02)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C140(0.94); C143(0.94)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C140(1.10); C143(1.10)  LDD0562  [2]
 LDCM0263  AC143 HCT 116 C140(1.07); C143(1.07)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C140(0.91); C143(0.91)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C140(1.01); C143(1.01)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C140(1.00); C143(1.00)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C140(1.14); C143(1.14)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C140(1.00); C143(1.00)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C140(1.25); C143(1.25)  LDD0586  [2]
 LDCM0271  AC150 HCT 116 C140(1.11); C143(1.11)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C140(0.95); C143(0.95)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C140(1.24); C143(1.24)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C140(1.19); C143(1.19)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C140(0.90); C143(0.90)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C140(0.85); C143(0.85)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C140(1.06); C143(1.06)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C140(0.97); C143(0.97)  LDD2161  [2]
 LDCM0281  AC21 HEK-293T C409(1.07)  LDD1520  [4]
 LDCM0289  AC29 HEK-293T C409(1.03)  LDD1528  [4]
 LDCM0296  AC35 HCT 116 C140(0.99); C143(0.99)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C140(1.02); C143(1.02)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C140(0.75); C143(0.75)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C140(1.06); C143(1.06)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C140(1.04); C143(1.04)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C140(1.00); C143(1.00)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C140(0.94); C143(0.94)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C140(1.10); C143(1.10)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C140(1.41); C143(1.41)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C140(0.90); C143(0.90)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C140(0.79); C143(0.79)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C140(0.98); C143(0.98)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C140(1.00); C143(1.00)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C140(1.07); C143(1.07)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C140(0.91); C143(0.91)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C409(1.06)  LDD1551  [4]
 LDCM0313  AC50 HCT 116 C140(1.27); C143(1.27)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C140(0.95); C143(0.95)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C140(1.02); C143(1.02)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C140(0.89); C143(0.89)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C140(1.18); C143(1.18)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C140(1.09); C143(1.09)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C140(0.91); C143(0.91)  LDD0636  [2]
 LDCM0325  AC61 HEK-293T C409(1.05)  LDD1564  [4]
 LDCM0332  AC68 HCT 116 C140(1.02); C143(1.02)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C140(0.99); C143(0.99)  LDD0650  [2]
 LDCM0335  AC70 HCT 116 C140(0.94); C143(0.94)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C140(1.20); C143(1.20)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C140(1.16); C143(1.16)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C140(1.08); C143(1.08)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C140(1.12); C143(1.12)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C140(1.03); C143(1.03)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C140(1.22); C143(1.22)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C140(1.11); C143(1.11)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C140(0.91); C143(0.91)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C140(1.18); C143(1.18)  LDD0661  [2]
 LDCM0346  AC80 HCT 116 C140(1.17); C143(1.17)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C140(1.19); C143(1.19)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C140(1.07); C143(1.07)  LDD0665  [2]
 LDCM0248  AKOS034007472 HEK-293T C409(1.06)  LDD1511  [4]
 LDCM0020  ARS-1620 HCC44 C87(0.97); C140(1.21); C143(1.21)  LDD2171  [2]
 LDCM0367  CL1 HEK-293T C409(1.01)  LDD1571  [4]
 LDCM0370  CL101 HEK-293T C409(1.05)  LDD1574  [4]
 LDCM0374  CL105 HEK-293T C409(0.99)  LDD1578  [4]
 LDCM0378  CL109 HEK-293T C409(0.98)  LDD1582  [4]
 LDCM0383  CL113 HEK-293T C409(1.04)  LDD1587  [4]
 LDCM0387  CL117 HCT 116 C140(1.12); C143(1.12)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C140(1.04); C143(1.04)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C140(1.07); C143(1.07)  LDD0706  [2]
 LDCM0391  CL120 HCT 116 C140(1.02); C143(1.02)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C140(0.93); C143(0.93)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C140(1.25); C143(1.25)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C140(1.05); C143(1.05)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C140(0.81); C143(0.81)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C409(1.01)  LDD1600  [4]
 LDCM0400  CL13 HEK-293T C409(1.22)  LDD1604  [4]
 LDCM0409  CL21 HEK-293T C409(1.05)  LDD1613  [4]
 LDCM0413  CL25 HEK-293T C409(0.96)  LDD1617  [4]
 LDCM0422  CL33 HEK-293T C409(0.96)  LDD1626  [4]
 LDCM0426  CL37 HEK-293T C409(1.13)  LDD1630  [4]
 LDCM0435  CL45 HEK-293T C409(1.17)  LDD1639  [4]
 LDCM0436  CL46 HCT 116 C140(1.44); C143(1.44)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C140(1.19); C143(1.19)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C140(1.16); C143(1.16)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C140(1.04); C143(1.04)  LDD0756  [2]
 LDCM0441  CL50 HCT 116 C140(0.84); C143(0.84)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C140(1.05); C143(1.05)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C140(1.35); C143(1.35)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C140(0.79); C143(0.79)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C140(0.88); C143(0.88)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C140(1.26); C143(1.26)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C140(0.96); C143(0.96)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C140(1.43); C143(1.43)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C140(0.96); C143(0.96)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C140(1.38); C143(1.38)  LDD0767  [2]
 LDCM0452  CL60 HCT 116 C140(1.83); C143(1.83)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C409(1.06)  LDD1656  [4]
 LDCM0461  CL69 HEK-293T C409(1.17)  LDD1664  [4]
 LDCM0466  CL73 HEK-293T C409(0.99)  LDD1669  [4]
 LDCM0475  CL81 HEK-293T C409(1.21)  LDD1678  [4]
 LDCM0479  CL85 HEK-293T C409(1.18)  LDD1682  [4]
 LDCM0484  CL9 HEK-293T C409(1.05)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C409(1.16)  LDD1691  [4]
 LDCM0492  CL97 HEK-293T C409(0.94)  LDD1695  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C409(0.99)  LDD1702  [1]
 LDCM0022  KB02 CAL-51 C409(2.05)  LDD2288  [5]
 LDCM0023  KB03 CAL-51 C409(1.54)  LDD2705  [5]
 LDCM0024  KB05 SKMEL24 C409(2.05)  LDD3323  [5]
 LDCM0021  THZ1 HCT 116 C87(0.97); C140(1.21); C143(1.21)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840