Details of the Target

General Information of Target

Target ID LDTP11320
Target Name Coiled-coil domain-containing protein 106 (CCDC106)
Gene Name CCDC106
Gene ID 29903
Synonyms
Coiled-coil domain-containing protein 106
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALYQRWRCLRLQGLQACRLHTAVVSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRT
IKISLPGGQKIDAVAWNTTPYQLARQISSTLADTAVAAQVNGEPYDLERPLETDSDLRFL
TFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRGPSTEYGFYHDFFLGKERTIRGSELPV
LERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLIEEKVTGPTATVYGCGTLVDLC
QGPHLRHTGQIGGLKLLSNSSSLWRSSGAPETLQRVSGISFPTTELLRVWEAWREEAELR
DHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIRAEYAHRGFSEVKTPTLFSTK
LWEQSGHWEHYQEDMFAVQPPGSDRPPSSQSDDSTRHITDTLALKPMNCPAHCLMFAHRP
RSWRELPLRLADFGALHRAEASGGLGGLTRLRCFQQDDAHIFCTTDQLEAEIQSCLDFLR
SVYAVLGFSFRLALSTRPSGFLGDPCLWDQAEQVLKQALKEFGEPWDLNSGDGAFYGPKI
DVHLHDALGRPHQCGTIQLDFQLPLRFDLQYKGQAGALERPVLIHRAVLGSVERLLGVLA
ESCGGKWPLWLSPFQVVVIPVGSEQEEYAKEAQQSLRAAGLVSDLDADSGLTLSRRIRRA
QLAHYNFQFVVGQKEQSKRTVNIRTRDNRRLGEWDLPEAVQRLVELQNTRVPNAEEIF
Target Bioclass
Other
Subcellular location
Nucleus
Function Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
Uniprot ID
Q9BWC9
Ensemble ID
ENST00000308964.7
HGNC ID
HGNC:30181

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C108(5.24)  LDD0371  [1]
DBIA
 Probe Info  		C108(1.06)  LDD0078  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
ENE
 Probe Info  		N.A.  LDD0006  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C108(5.24)  LDD0371  [1]
 LDCM0215  AC10 HEK-293T C184(0.94)  LDD1508  [7]
 LDCM0259  AC14 HEK-293T C184(1.05)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C184(1.10)  LDD1513  [7]
 LDCM0277  AC18 HEK-293T C184(0.97)  LDD1516  [7]
 LDCM0279  AC2 HEK-293T C184(0.84)  LDD1518  [7]
 LDCM0281  AC21 HEK-293T C184(0.94); C108(1.05)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C184(0.96)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C184(1.00)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C184(0.99)  LDD1523  [7]
 LDCM0286  AC26 HEK-293T C184(1.02)  LDD1525  [7]
 LDCM0289  AC29 HEK-293T C184(1.10); C108(1.05)  LDD1528  [7]
 LDCM0291  AC30 HEK-293T C184(1.04)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C184(1.16)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C184(1.15)  LDD1532  [7]
 LDCM0295  AC34 HEK-293T C184(0.93)  LDD1534  [7]
 LDCM0298  AC37 HEK-293T C184(1.03); C108(1.05)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C184(1.11)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C184(1.08)  LDD1539  [7]
 LDCM0302  AC40 HEK-293T C184(0.98)  LDD1541  [7]
 LDCM0304  AC42 HEK-293T C184(1.11)  LDD1543  [7]
 LDCM0307  AC45 HEK-293T C184(1.16); C108(1.12)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C184(1.00)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C184(1.09)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C184(0.94)  LDD1549  [7]
 LDCM0312  AC5 HEK-293T C184(1.04); C108(0.94)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C184(0.97)  LDD1552  [7]
 LDCM0316  AC53 HEK-293T C184(1.13); C108(1.03)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C184(1.06)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C184(1.01)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C184(0.93)  LDD1558  [7]
 LDCM0321  AC58 HEK-293T C184(0.98)  LDD1560  [7]
 LDCM0323  AC6 HEK-293T C184(1.02)  LDD1562  [7]
 LDCM0325  AC61 HEK-293T C184(1.07); C108(1.05)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C184(1.05)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C184(1.16)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C184(1.00)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C184(1.02)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C184(0.94)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C184(1.01); C108(1.04)  LDD1511  [7]
 LDCM0275  AKOS034007705 HEK-293T C184(0.99)  LDD1514  [7]
 LDCM0020  ARS-1620 HCC44 C108(1.06)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C184(1.09)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C184(1.50)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C184(0.92)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C184(1.05)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C184(0.93)  LDD1575  [7]
 LDCM0373  CL104 HEK-293T C184(0.88)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C184(0.94)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C184(1.04)  LDD1579  [7]
 LDCM0377  CL108 HEK-293T C184(1.00)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C184(0.97)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C184(1.47)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C184(1.16)  LDD1584  [7]
 LDCM0382  CL112 HEK-293T C184(1.06)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C184(1.10)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C184(0.98)  LDD1588  [7]
 LDCM0386  CL116 HEK-293T C184(0.96)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C184(1.04)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C184(1.07)  LDD1592  [7]
 LDCM0390  CL12 HEK-293T C184(1.13)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C184(0.93)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C184(1.02)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C184(0.99)  LDD1597  [7]
 LDCM0395  CL124 HEK-293T C184(0.99)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C184(0.97)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C184(1.03)  LDD1601  [7]
 LDCM0399  CL128 HEK-293T C184(0.95)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C184(1.21)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C184(0.99)  LDD1605  [7]
 LDCM0403  CL16 HEK-293T C184(0.92)  LDD1607  [7]
 LDCM0405  CL18 HEK-293T C184(0.89)  LDD1609  [7]
 LDCM0407  CL2 HEK-293T C184(1.01)  LDD1611  [7]
 LDCM0409  CL21 HEK-293T C184(1.24); C108(0.98)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C184(1.34)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C184(1.52)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C184(1.15)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C184(1.00)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C184(1.04)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C184(0.92)  LDD1620  [7]
 LDCM0419  CL30 HEK-293T C184(0.91)  LDD1623  [7]
 LDCM0422  CL33 HEK-293T C184(1.25); C108(0.94)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C184(1.27)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C184(1.57)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C184(1.18)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C184(1.05)  LDD1630  [7]
 LDCM0429  CL4 HEK-293T C184(1.06)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C184(0.99)  LDD1634  [7]
 LDCM0432  CL42 HEK-293T C184(0.99)  LDD1636  [7]
 LDCM0435  CL45 HEK-293T C184(1.22); C108(0.97)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C184(1.38)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C184(1.64)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C184(1.07)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C184(1.04)  LDD1643  [7]
 LDCM0441  CL50 HEK-293T C184(1.17)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C184(0.96)  LDD1646  [7]
 LDCM0445  CL54 HEK-293T C184(1.09)  LDD1648  [7]
 LDCM0448  CL57 HEK-293T C184(1.28); C108(1.02)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C184(1.31)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C184(1.43)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C184(0.92)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C184(1.03)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C184(1.01)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C184(1.14)  LDD1657  [7]
 LDCM0456  CL64 HEK-293T C184(0.92)  LDD1659  [7]
 LDCM0458  CL66 HEK-293T C184(1.17)  LDD1661  [7]
 LDCM0461  CL69 HEK-293T C184(1.28); C108(1.04)  LDD1664  [7]
 LDCM0463  CL70 HEK-293T C184(1.38)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C184(1.62)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C184(1.31)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C184(0.94)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C184(1.09)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C184(0.92)  LDD1672  [7]
 LDCM0471  CL78 HEK-293T C184(1.02)  LDD1674  [7]
 LDCM0475  CL81 HEK-293T C184(1.22); C108(1.00)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C184(1.31)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C184(1.56)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C184(1.08)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C184(0.99)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C184(0.94)  LDD1683  [7]
 LDCM0482  CL88 HEK-293T C184(0.83)  LDD1685  [7]
 LDCM0484  CL9 HEK-293T C184(1.13); C108(1.08)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C184(1.11)  LDD1688  [7]
 LDCM0488  CL93 HEK-293T C184(1.12); C108(0.92)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C184(1.12)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C184(1.75)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C184(0.98)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C184(1.20)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C184(0.96)  LDD1696  [7]
 LDCM0427  Fragment51 HEK-293T C184(0.98)  LDD1631  [7]
 LDCM0022  KB02 HCT 116 C108(2.21)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C108(2.00)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C108(3.52)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-dependent L-type calcium channel subunit alpha-1S (CACNA1S) Calcium channel alpha-1 subunit (TC 1.A.1.11) family Q13698
Cellular tumor antigen p53 (TP53) P53 family P04637
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Kelch repeat and BTB domain-containing protein 7 (KBTBD7) . Q8WVZ9
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) . Q969R5
Melanoma-associated antigen 11 (MAGEA11) . P43364
Nuclear transport factor 2 (NUTF2) . P61970
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402