Details of the Target

General Information of Target

Target ID LDTP11236
Target Name Brain-enriched guanylate kinase-associated protein (BEGAIN)
Gene Name BEGAIN
Gene ID 57596
Synonyms
KIAA1446; Brain-enriched guanylate kinase-associated protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPLSPPLCTLPPGPEPPRFVCYCEGEESGEGDRGGFNLYVTDAAELWSTCFTPDSLAAL
KARFGLSAAEDITPRFRAACEQQAVALTLQEDRASLTLSGGPSALAFDLSKVPGPEAAPR
LRALTLGLAKRVWSLERRLAAAEETAVSPRKSPRPAGPQLFLPDPDPQRGGPGPGVRRRC
PGESLINPGFKSKKPAGGVDFDET
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May sustain the structure of the postsynaptic density (PSD).
Uniprot ID
Q9BUH8
Ensemble ID
ENST00000355173.7
HGNC ID
HGNC:24163

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C124(0.90); C133(0.90)  LDD0533  [1]
IPM
 Probe Info  		C442(0.00); C491(0.00)  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C124(0.90); C133(0.90)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C124(1.05); C133(1.05)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C124(1.18); C133(1.18)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C124(1.34); C133(1.34)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C124(1.26); C133(1.26)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C124(1.34); C133(1.34)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C124(1.09); C133(1.09)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C124(1.08); C133(1.03)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C124(1.27); C133(1.26)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C124(0.93); C133(1.38)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C124(1.06); C133(1.10)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C124(1.05); C133(1.17)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C124(1.11); C133(0.71)  LDD0546  [1]
 LDCM0246  AC128 HCT 116 C124(1.24); C133(1.24)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C124(1.13); C133(1.13)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C124(1.30); C133(1.30)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C124(1.20); C133(1.20)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C124(1.12); C133(1.12)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C124(0.71); C133(0.71)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C124(1.19); C133(1.19)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C124(0.82); C133(0.82)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C124(0.85); C133(0.85)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C124(0.86); C133(0.86)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C124(0.91); C133(0.91)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C124(0.94); C133(0.94)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C124(0.94); C133(0.94)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C124(1.07); C133(1.07)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C124(0.93); C133(0.93)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C124(1.15); C133(1.15)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C124(1.44); C133(1.44)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C124(1.13); C133(1.13)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C124(1.32); C133(1.32)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C124(1.45); C133(1.45)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C124(2.47); C133(2.47)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C124(1.60); C133(1.60)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C124(1.68); C133(1.68)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C124(1.16); C133(1.16)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C124(1.62); C133(1.62)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C124(1.90); C133(1.90)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C124(1.41); C133(1.41)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C124(2.04); C133(2.04)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C124(1.19); C133(1.19)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C124(1.48); C133(1.48)  LDD2161  [1]
 LDCM0285  AC25 HCT 116 C124(0.90); C133(0.90)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C124(0.96); C133(0.96)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C124(1.49); C133(1.49)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C124(1.34); C133(1.34)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C124(1.16); C133(1.16)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C124(1.04); C133(1.04)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C124(1.36); C133(1.36)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C124(1.07); C133(1.07)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C124(1.27); C133(1.27)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C124(1.56); C133(1.56)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C124(0.70); C133(0.70)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C124(1.00); C133(1.00)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C124(0.81); C133(0.81)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C124(0.71); C133(0.71)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C124(0.89); C133(0.89)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C124(0.99); C133(0.99)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C124(0.78); C133(0.78)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C124(1.10); C133(1.10)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C124(0.95); C133(0.95)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C124(0.77); C133(0.77)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C124(1.16); C133(1.16)  LDD0624  [1]
 LDCM0365  AC98 HCT 116 C124(1.71); C133(1.71)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C124(0.90); C133(0.90)  LDD0683  [1]
 LDCM0382  CL112 HCT 116 C124(0.99); C133(0.99)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C124(1.21); C133(1.21)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C124(1.24); C133(1.24)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C124(1.14); C133(1.14)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C124(1.15); C133(1.15)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C124(1.39); C133(1.39)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C124(0.83); C133(0.83)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C124(1.08); C133(1.08)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C124(0.85); C133(0.85)  LDD0708  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Protein mab-21-like 3 (MAB21L3) Mab-21 family Q8N8X9
GTP-binding protein GEM (GEM) RGK family P55040
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 319 (ZNF319) Krueppel C2H2-type zinc-finger protein family Q9P2F9
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Retinoblastoma-like protein 1 (RBL1) Retinoblastoma protein (RB) family P28749
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
Bone morphogenetic protein 7 (BMP7) TGF-beta family P18075
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Proline-rich protein 35 (PRR35) . P0CG20
RAS protein activator like-3 (RASAL3) . Q86YV0

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255