Details of the Target

General Information of Target

Target ID LDTP10859
Target Name Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2)
Gene Name ACOX2
Gene ID 8309
Synonyms
Peroxisomal acyl-coenzyme A oxidase 2; EC 1.17.99.3; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase; THCA-CoA oxidase; THCCox
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP
RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT
QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
Target Bioclass
Enzyme
Family
Acyl-CoA oxidase family
Subcellular location
Peroxisome
Function Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. Capable of oxidizing short as well as long chain 2-methyl branched fatty acids.
Uniprot ID
Q99424
Ensemble ID
ENST00000302819.10
HGNC ID
HGNC:120

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C412(2.66)  LDD1699  [1]
IPM
 Probe Info  		C412(0.00); C65(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C412(1.48)  LDD3380  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C412(0.71)  LDD2142  [1]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C412(1.09)  LDD2112  [1]
 LDCM0545  Acetamide MDA-MB-231 C412(0.47)  LDD2138  [1]
 LDCM0520  AKOS000195272 MDA-MB-231 C412(0.64)  LDD2113  [1]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C412(1.93)  LDD1702  [1]
 LDCM0022  KB02 A2780 C412(1.83)  LDD2254  [3]
 LDCM0023  KB03 MDA-MB-231 C412(4.92)  LDD1701  [1]
 LDCM0024  KB05 OV-90 C412(1.48)  LDD3380  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C412(1.56)  LDD2092  [1]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C412(2.04)  LDD2094  [1]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C412(0.39)  LDD2096  [1]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C412(1.01)  LDD2097  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C412(0.79)  LDD2100  [1]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C412(0.69)  LDD2101  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C412(0.56)  LDD2104  [1]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C412(0.47)  LDD2106  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C412(0.76)  LDD2108  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C412(0.53)  LDD2114  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C412(0.60)  LDD2115  [1]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C412(0.74)  LDD2116  [1]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C412(0.61)  LDD2118  [1]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C412(0.73)  LDD2122  [1]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C412(0.75)  LDD2124  [1]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C412(5.12)  LDD2126  [1]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C412(0.55)  LDD2133  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C412(0.57)  LDD2134  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C412(1.10)  LDD2141  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C412(0.46)  LDD2145  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C412(1.40)  LDD2148  [1]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C412(0.49)  LDD2150  [1]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C412(0.59)  LDD2151  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein light chain Tctex-type 1 (DYNLT1) Dynein light chain Tctex-type family P63172

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840