Details of the Target

General Information of Target

Target ID LDTP10623
Target Name Zinc finger matrin-type protein 2 (ZMAT2)
Gene Name ZMAT2
Gene ID 153527
Synonyms
Zinc finger matrin-type protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASSASARTPAGKRVINQEELRRLMKEKQRLSTSRKRIESPFAKYNRLGQLSCALCNTPV
KSELLWQTHVLGKQHREKVAELKGAKEASQGSSASSAPHSVKRKAPDADDQDVKRAKATL
VPQVQPSTSAWTTNFDKIGKEFIRATPSKPSGLSLLPDYEDEEEEEEEEEGDGERKRGDA
SKPLSDAQGKEHSVSSSREVTSSVLPNDFFSTNPPKAPIIPHSGSIEKAEIHEKVVERRE
NTAEALPEGFFDDPEVDARVRKVDAPKDQMDKEWDEFQKAMRQVNTISEAIVAEEDEEGR
LDRQIGEIDEQIECYRRVEKLRNRQDEIKNKLKEILTIKELQKKEEENADSDDEGELQDL
LSQDWRVKGALL
Target Bioclass
Other
Subcellular location
Nucleus
Function Involved in pre-mRNA splicing as a component of the spliceosome.
Uniprot ID
Q96NC0
Ensemble ID
ENST00000274712.8
HGNC ID
HGNC:26433

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K123(3.13); K45(6.43); K64(4.35)  LDD0277  [1]
IA-alkyne
 Probe Info  		C85(5.13); C82(7.69); C87(9.05)  LDD2157  [2]
Probe 1
 Probe Info  		Y140(37.72)  LDD3495  [3]
HHS-465
 Probe Info  		Y140(7.76); Y21(10.00)  LDD2237  [4]
DBIA
 Probe Info  		C87(0.95)  LDD1492  [5]
Lodoacetamide azide
 Probe Info  		C82(0.00); C85(0.00); C87(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
NHS
 Probe Info  		K61(0.00); K8(0.00)  LDD0010  [8]
Ox-W18
 Probe Info  		N.A.  LDD2175  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C87(0.86)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C87(0.85)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C87(0.97)  LDD1513  [5]
 LDCM0280  AC20 HEK-293T C87(0.67)  LDD1519  [5]
 LDCM0282  AC22 HEK-293T C87(0.91)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C87(1.00)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C87(1.08)  LDD1523  [5]
 LDCM0288  AC28 HEK-293T C87(0.67)  LDD1527  [5]
 LDCM0291  AC30 HEK-293T C87(0.89)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C87(0.93)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C87(0.75)  LDD1532  [5]
 LDCM0297  AC36 HEK-293T C87(0.80)  LDD1536  [5]
 LDCM0299  AC38 HEK-293T C87(0.88)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C87(0.94)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C87(0.57)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C87(0.75)  LDD1541  [5]
 LDCM0306  AC44 HEK-293T C87(0.75)  LDD1545  [5]
 LDCM0308  AC46 HEK-293T C87(0.85)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C87(0.39)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C87(0.65)  LDD1549  [5]
 LDCM0315  AC52 HEK-293T C87(0.66)  LDD1554  [5]
 LDCM0317  AC54 HEK-293T C87(0.49)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C87(0.93)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C87(0.73)  LDD1558  [5]
 LDCM0323  AC6 HEK-293T C87(0.88)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C87(0.72)  LDD1563  [5]
 LDCM0326  AC62 HEK-293T C87(0.90)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C87(0.85)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C87(1.05)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C87(1.00)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C87(0.92)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C87(0.84)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C87(0.94)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C87(0.89)  LDD1572  [5]
 LDCM0370  CL101 HEK-293T C87(0.73)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C87(0.61)  LDD1575  [5]
 LDCM0374  CL105 HEK-293T C87(0.72)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C87(0.80)  LDD1579  [5]
 LDCM0378  CL109 HEK-293T C87(0.72)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C87(1.04)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C87(0.59)  LDD1584  [5]
 LDCM0383  CL113 HEK-293T C87(0.59)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C87(0.75)  LDD1588  [5]
 LDCM0387  CL117 HEK-293T C87(0.82)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C87(0.74)  LDD1592  [5]
 LDCM0390  CL12 HEK-293T C87(0.91)  LDD1594  [5]
 LDCM0392  CL121 HEK-293T C87(0.84)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C87(0.37)  LDD1597  [5]
 LDCM0396  CL125 HEK-293T C87(0.76)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C87(0.98)  LDD1601  [5]
 LDCM0400  CL13 HEK-293T C87(0.79)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C87(1.04)  LDD1605  [5]
 LDCM0407  CL2 HEK-293T C87(0.97)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C87(1.08)  LDD1612  [5]
 LDCM0410  CL22 HEK-293T C87(0.98)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C87(1.14)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C87(0.96)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C87(0.67)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C87(0.86)  LDD1618  [5]
 LDCM0421  CL32 HEK-293T C87(0.98)  LDD1625  [5]
 LDCM0423  CL34 HEK-293T C87(1.02)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C87(1.00)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C87(0.88)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C87(0.71)  LDD1630  [5]
 LDCM0434  CL44 HEK-293T C87(0.95)  LDD1638  [5]
 LDCM0436  CL46 HEK-293T C87(0.99)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C87(0.96)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C87(0.82)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C87(0.87)  LDD1643  [5]
 LDCM0441  CL50 HEK-293T C87(0.80)  LDD1645  [5]
 LDCM0447  CL56 HEK-293T C87(1.08)  LDD1650  [5]
 LDCM0449  CL58 HEK-293T C87(1.04)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C87(0.94)  LDD1653  [5]
 LDCM0452  CL60 HEK-293T C87(0.88)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C87(0.77)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C87(0.33)  LDD1657  [5]
 LDCM0460  CL68 HEK-293T C87(1.06)  LDD1663  [5]
 LDCM0463  CL70 HEK-293T C87(1.11)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C87(1.02)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C87(1.17)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C87(1.00)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C87(0.93)  LDD1670  [5]
 LDCM0473  CL8 HEK-293T C87(0.61)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C87(1.00)  LDD1677  [5]
 LDCM0476  CL82 HEK-293T C87(1.17)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C87(0.86)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C87(0.86)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C87(0.77)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C87(1.36)  LDD1683  [5]
 LDCM0487  CL92 HEK-293T C87(0.85)  LDD1690  [5]
 LDCM0489  CL94 HEK-293T C87(1.02)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C87(0.67)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C87(0.88)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C87(0.63)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C87(0.74)  LDD1696  [5]
 LDCM0427  Fragment51 HEK-293T C87(0.90)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C87(0.95)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C87(0.99)  LDD1497  [5]
 LDCM0024  KB05 HEK-293T C87(0.96)  LDD1502  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenylate kinase 8 (AK8) Adenylate kinase family Q96MA6
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Protein NDRG1 (NDRG1) NDRG family Q92597
Presenilin-2 (PSEN2) Peptidase A22A family P49810
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase TRIM36 (TRIM36) TRIM/RBCC family Q9NQ86
E3 ubiquitin-protein ligase TRIM37 (TRIM37) TRIM/RBCC family O94972
Ataxin-3 (ATXN3) . P54252
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Peroxisome assembly protein 26 (PEX26) Peroxin-26 family Q7Z412
Alpha-synuclein (SNCA) Synuclein family P37840
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Homeobox protein MOX-2 (MEOX2) . P50222
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Other
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Ataxin-1 (ATXN1) ATXN1 family P54253
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) CALCOCO family Q9P1Z2
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Peripherin (PRPH) Intermediate filament family P41219
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
tRNA-splicing endonuclease subunit Sen15 (TSEN15) SEN15 family Q8WW01
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Huntingtin-associated protein 1 (HAP1) . P54257
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Nuclear transport factor 2 (NUTF2) . P61970
Polyhomeotic-like protein 2 (PHC2) . Q8IXK0
PRKCA-binding protein (PICK1) . Q9NRD5
Sperm-associated antigen 5 (SPAG5) . Q96R06
TNFAIP3-interacting protein 1 (TNIP1) . Q15025

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252