Details of the Target

General Information of Target

Target ID LDTP10384
Target Name Protein disulfide isomerase CRELD1 (CRELD1)
Gene Name CRELD1
Gene ID 78987
Synonyms
CIRRIN; Protein disulfide isomerase CRELD1; EC 5.3.4.1; Cysteine-rich with EGF-like domain protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG
MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTST
NNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLH
ANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPR
KHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEA
DNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKS
PSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMC
AHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECG
RCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHG
CEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF
Target Bioclass
Enzyme
Family
CRELD family
Subcellular location
Membrane
Function Protein disulfide isomerase. Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane.
Uniprot ID
Q96HD1
Ensemble ID
ENST00000326434.9
HGNC ID
HGNC:14630

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.F215L .
A375 SNV: p.L14H .
COLO678 SNV: p.C135G .
Ishikawa (Heraklio) 02 ER SNV: p.E104G .
MCC26 SNV: p.W15C .
MELHO SNV: p.C135G .
NCIH1155 SNV: p.S207N .
NCIH1666 Insertion: p.G157WfsTer14 .
PF382 SNV: p.P45L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		8.05  LDD0318  [1]
DBIA
 Probe Info  		C292(1.62)  LDD3413  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C135(0.99); C292(1.18)  LDD1509  [6]
 LDCM0259  AC14 HEK-293T C278(0.92); C332(0.94)  LDD1512  [6]
 LDCM0278  AC19 HEK-293T C135(1.10); C292(1.35)  LDD1517  [6]
 LDCM0282  AC22 HEK-293T C278(1.04); C332(0.92)  LDD1521  [6]
 LDCM0284  AC24 HEK-293T C292(1.20)  LDD1523  [6]
 LDCM0287  AC27 HEK-293T C135(1.09); C292(1.01)  LDD1526  [6]
 LDCM0290  AC3 HEK-293T C135(1.05); C292(0.94)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C278(1.00); C332(0.84)  LDD1530  [6]
 LDCM0293  AC32 HEK-293T C292(1.16)  LDD1532  [6]
 LDCM0296  AC35 HEK-293T C135(0.87); C292(1.08)  LDD1535  [6]
 LDCM0299  AC38 HEK-293T C278(0.95); C332(0.89)  LDD1538  [6]
 LDCM0302  AC40 HEK-293T C292(1.07)  LDD1541  [6]
 LDCM0305  AC43 HEK-293T C135(1.13); C292(1.20)  LDD1544  [6]
 LDCM0308  AC46 HEK-293T C278(1.07); C332(0.82)  LDD1547  [6]
 LDCM0310  AC48 HEK-293T C292(1.25)  LDD1549  [6]
 LDCM0314  AC51 HEK-293T C135(1.03); C292(1.05)  LDD1553  [6]
 LDCM0317  AC54 HEK-293T C278(1.25); C332(1.00)  LDD1556  [6]
 LDCM0319  AC56 HEK-293T C292(1.23)  LDD1558  [6]
 LDCM0322  AC59 HEK-293T C135(1.00); C292(1.12)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C278(1.10); C332(0.90)  LDD1562  [6]
 LDCM0326  AC62 HEK-293T C278(0.93); C332(0.91)  LDD1565  [6]
 LDCM0328  AC64 HEK-293T C292(1.19)  LDD1567  [6]
 LDCM0345  AC8 HEK-293T C292(1.10)  LDD1569  [6]
 LDCM0275  AKOS034007705 HEK-293T C292(1.16)  LDD1514  [6]
 LDCM0368  CL10 HEK-293T C278(1.07); C332(1.05)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C135(0.89); C292(1.01); C332(1.37)  LDD1573  [6]
 LDCM0373  CL104 HEK-293T C135(1.03); C292(1.15); C332(0.88)  LDD1577  [6]
 LDCM0377  CL108 HEK-293T C135(1.08); C292(1.14); C332(0.84)  LDD1581  [6]
 LDCM0382  CL112 HEK-293T C135(0.91); C292(1.17); C332(0.94)  LDD1586  [6]
 LDCM0386  CL116 HEK-293T C135(0.90); C292(1.29); C332(1.20)  LDD1590  [6]
 LDCM0390  CL12 HEK-293T C292(1.34)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C135(1.01); C292(1.13); C332(0.96)  LDD1595  [6]
 LDCM0395  CL124 HEK-293T C135(1.01); C292(1.13); C332(0.88)  LDD1599  [6]
 LDCM0399  CL128 HEK-293T C135(0.80); C292(1.03); C332(1.04)  LDD1603  [6]
 LDCM0403  CL16 HEK-293T C135(0.99); C292(1.12); C332(0.94)  LDD1607  [6]
 LDCM0406  CL19 HEK-293T C135(1.12); C292(1.09)  LDD1610  [6]
 LDCM0410  CL22 HEK-293T C278(0.91); C332(0.97)  LDD1614  [6]
 LDCM0412  CL24 HEK-293T C292(1.40)  LDD1616  [6]
 LDCM0416  CL28 HEK-293T C135(1.11); C292(1.10); C332(0.81)  LDD1620  [6]
 LDCM0420  CL31 HEK-293T C135(1.05); C292(1.09)  LDD1624  [6]
 LDCM0423  CL34 HEK-293T C278(1.13); C332(1.07)  LDD1627  [6]
 LDCM0425  CL36 HEK-293T C292(1.48)  LDD1629  [6]
 LDCM0429  CL4 HEK-293T C135(0.96); C292(1.08); C332(1.12)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C135(1.03); C292(1.14); C332(0.85)  LDD1634  [6]
 LDCM0433  CL43 HEK-293T C135(0.83); C292(1.10)  LDD1637  [6]
 LDCM0436  CL46 HEK-293T C278(1.17); C332(0.43)  LDD1640  [6]
 LDCM0438  CL48 HEK-293T C292(1.27)  LDD1642  [6]
 LDCM0443  CL52 HEK-293T C135(0.99); C292(1.06); C332(1.01)  LDD1646  [6]
 LDCM0446  CL55 HEK-293T C135(1.18); C292(1.00)  LDD1649  [6]
 LDCM0449  CL58 HEK-293T C278(0.86); C332(1.00)  LDD1652  [6]
 LDCM0452  CL60 HEK-293T C292(1.47)  LDD1655  [6]
 LDCM0456  CL64 HEK-293T C135(0.74); C292(1.06); C332(1.00)  LDD1659  [6]
 LDCM0459  CL67 HEK-293T C135(1.10); C292(1.24)  LDD1662  [6]
 LDCM0462  CL7 HEK-293T C135(0.98); C292(1.07)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C278(0.99); C332(1.02)  LDD1666  [6]
 LDCM0465  CL72 HEK-293T C292(1.48)  LDD1668  [6]
 LDCM0469  CL76 HEK-293T C135(1.04); C292(1.17); C332(1.00)  LDD1672  [6]
 LDCM0472  CL79 HEK-293T C135(1.00); C292(0.95)  LDD1675  [6]
 LDCM0476  CL82 HEK-293T C278(0.94); C332(0.97)  LDD1679  [6]
 LDCM0478  CL84 HEK-293T C292(1.24)  LDD1681  [6]
 LDCM0482  CL88 HEK-293T C135(0.85); C292(1.14); C332(1.17)  LDD1685  [6]
 LDCM0486  CL91 HEK-293T C135(0.97); C292(1.15)  LDD1689  [6]
 LDCM0489  CL94 HEK-293T C278(0.97); C332(0.96)  LDD1692  [6]
 LDCM0491  CL96 HEK-293T C292(1.24)  LDD1694  [6]
 LDCM0022  KB02 CAL-120 C343(1.93)  LDD2284  [2]
 LDCM0023  KB03 CAL-120 C343(3.13)  LDD2701  [2]
 LDCM0024  KB05 RVH-421 C292(1.62)  LDD3413  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402