Details of the Target

General Information of Target

Target ID LDTP10237
Target Name Endoplasmic reticulum lectin 1 (ERLEC1)
Gene Name ERLEC1
Gene ID 27248
Synonyms
C2orf30; XTP3TPB; Endoplasmic reticulum lectin 1; ER lectin; Erlectin; XTP3-transactivated gene B protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVVDFWTWEQTFQELIQEAKPRATWTLKLDGNLQLDCLAQGWKQYQQRAFGWFRCSSCQR
SWASAQVQILCHTYWEHWTSQGQVRMRLFGQRCQKCSWSQYEMPEFSSDSTMRILSNLVQ
HILKKYYGNGTRKSPEMPVILEVSLEGSHDTANCEACTLGICGQGLKSCMTKPSKSLLPH
LKTGNSSPGIGAVYLANQAKNQSAEAKEAKGSGYEKLGPSRDPDPLNICVFILLLVFIVV
KCFTSE
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum lumen
Function
Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins.
Uniprot ID
Q96DZ1
Ensemble ID
ENST00000185150.9
HGNC ID
HGNC:25222

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P442L DBIA    Probe Info 
IGROV1 SNV: p.H443N .
LUDLU1 SNV: p.S173L DBIA    Probe Info 
MFE319 SNV: p.N145D .
NCIH1155 SNV: p.H413Y DBIA    Probe Info 
NCIH3122 SNV: p.D403Y DBIA    Probe Info 
RVH421 SNV: p.K163N DBIA    Probe Info 
U2OS SNV: p.I117V .
YSCCC SNV: p.E92Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C113(3.34)  LDD3310  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C113(0.00); C421(0.00); C261(0.00)  LDD0162  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
NAIA_5
 Probe Info  		C261(0.00); C79(0.00); C344(0.00); C421(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C261(0.93)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C261(1.09)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C261(0.98)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C261(0.87)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C261(0.85)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C261(1.08)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C261(1.23)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C261(0.74)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C261(1.03)  LDD1519  [6]
 LDCM0282  AC22 HEK-293T C261(0.79)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C261(0.84)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C261(0.87)  LDD1523  [6]
 LDCM0286  AC26 HEK-293T C261(0.92)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C261(0.81)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C261(1.07)  LDD1527  [6]
 LDCM0290  AC3 HEK-293T C261(1.06)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C261(0.82)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C261(1.07)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C261(0.66)  LDD1532  [6]
 LDCM0295  AC34 HEK-293T C261(0.94)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C261(0.95)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C261(1.09)  LDD1536  [6]
 LDCM0299  AC38 HEK-293T C261(1.02)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C261(1.03)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C261(0.95)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C261(0.84)  LDD1541  [6]
 LDCM0304  AC42 HEK-293T C261(0.85)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C261(1.19)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C261(1.20)  LDD1545  [6]
 LDCM0308  AC46 HEK-293T C261(1.19)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C261(0.97)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C261(0.68)  LDD1549  [6]
 LDCM0313  AC50 HEK-293T C261(1.07)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C261(0.79)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C261(0.81)  LDD1554  [6]
 LDCM0317  AC54 HEK-293T C261(0.84)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C261(0.81)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C261(1.20)  LDD1558  [6]
 LDCM0321  AC58 HEK-293T C261(1.19)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C261(1.06)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C261(1.09)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C261(1.20)  LDD1563  [6]
 LDCM0326  AC62 HEK-293T C261(0.94)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C261(1.09)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C261(1.15)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C261(0.82)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C261(0.89)  LDD1569  [6]
 LDCM0275  AKOS034007705 HEK-293T C261(0.76)  LDD1514  [6]
 LDCM0630  CCW28-3 231MFP C22(1.49)  LDD2214  [7]
 LDCM0368  CL10 HEK-293T C261(1.67)  LDD1572  [6]
 LDCM0372  CL103 HEK-293T C261(0.79)  LDD1576  [6]
 LDCM0376  CL107 HEK-293T C261(0.96)  LDD1580  [6]
 LDCM0379  CL11 HEK-293T C261(1.68)  LDD1583  [6]
 LDCM0381  CL111 HEK-293T C261(1.12)  LDD1585  [6]
 LDCM0385  CL115 HEK-293T C261(0.89)  LDD1589  [6]
 LDCM0389  CL119 HEK-293T C261(0.90)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C261(1.17)  LDD1594  [6]
 LDCM0394  CL123 HEK-293T C261(1.06)  LDD1598  [6]
 LDCM0398  CL127 HEK-293T C261(1.03)  LDD1602  [6]
 LDCM0402  CL15 HEK-293T C261(1.43)  LDD1606  [6]
 LDCM0405  CL18 HEK-293T C261(1.20)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C261(1.07)  LDD1610  [6]
 LDCM0408  CL20 HEK-293T C261(1.36)  LDD1612  [6]
 LDCM0410  CL22 HEK-293T C261(1.60)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C261(1.49)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C261(1.20)  LDD1616  [6]
 LDCM0415  CL27 HEK-293T C261(1.19)  LDD1619  [6]
 LDCM0418  CL3 HEK-293T C261(1.33)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C261(0.90)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C261(1.28)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C261(1.21)  LDD1625  [6]
 LDCM0423  CL34 HEK-293T C261(1.24)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C261(1.29)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C261(1.48)  LDD1629  [6]
 LDCM0428  CL39 HEK-293T C261(1.00)  LDD1632  [6]
 LDCM0432  CL42 HEK-293T C261(1.06)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C261(1.38)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C261(2.58)  LDD1638  [6]
 LDCM0436  CL46 HEK-293T C261(1.18)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C261(1.82)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C261(1.85)  LDD1642  [6]
 LDCM0445  CL54 HEK-293T C261(1.62)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C261(1.17)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C261(1.12)  LDD1650  [6]
 LDCM0449  CL58 HEK-293T C261(1.62)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C261(1.45)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C261(1.30)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C261(1.04)  LDD1655  [6]
 LDCM0455  CL63 HEK-293T C261(0.84)  LDD1658  [6]
 LDCM0458  CL66 HEK-293T C261(1.49)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C261(1.39)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C261(1.15)  LDD1663  [6]
 LDCM0462  CL7 HEK-293T C261(1.37)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C261(1.35)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C261(1.38)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C261(0.85)  LDD1668  [6]
 LDCM0471  CL78 HEK-293T C261(1.00)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C261(0.90)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C261(1.46)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C261(1.30)  LDD1677  [6]
 LDCM0476  CL82 HEK-293T C261(1.29)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C261(1.27)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C261(1.45)  LDD1681  [6]
 LDCM0481  CL87 HEK-293T C261(1.24)  LDD1684  [6]
 LDCM0485  CL90 HEK-293T C261(1.29)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C261(0.99)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C261(1.74)  LDD1690  [6]
 LDCM0489  CL94 HEK-293T C261(1.35)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C261(1.09)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C261(1.09)  LDD1694  [6]
 LDCM0494  CL99 HEK-293T C261(0.93)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C261(1.41)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C261(1.45)  LDD1671  [6]
 LDCM0022  KB02 769-P C113(1.85)  LDD2246  [1]
 LDCM0023  KB03 769-P C113(2.25)  LDD2663  [1]
 LDCM0024  KB05 COLO792 C113(3.34)  LDD3310  [1]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.