Details of the Target

General Information of Target

Target ID LDTP10179
Target Name Leucine-rich repeat-containing protein 45 (LRRC45)
Gene Name LRRC45
Gene ID 201255
Synonyms
Leucine-rich repeat-containing protein 45
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNG
SRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHF
RAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLF
NVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELG
LCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEG
LEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKM
KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKGQVTRAQEAEENYVIKRELA
VVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETETLGALRE
MQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRELKLQLQELSDTWQAHL
ARGGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQRVVELETQDHIHRNLLNRV
EAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLREADSMAAVAEM
RQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEELKAEVRLLKGPPPFEDPLAFDG
LSLARHLDEDSLPSSDEELLGVGVGAALQDALYPLSPRDARFFRRLERPAKDSEGSSDSD
ADELAAPYSQGLDN
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.
Uniprot ID
Q96CN5
Ensemble ID
ENST00000306688.8
HGNC ID
HGNC:28302

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C83(2.42)  LDD3409  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C385(1.03)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C385(0.91)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C385(1.04)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C385(1.01)  LDD1512  [3]
 LDCM0277  AC18 HEK-293T C385(1.40)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C385(1.12)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C385(0.97)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C385(1.06)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C385(1.07)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C385(0.89)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C83(0.90)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C385(1.09)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C385(1.06)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C385(0.91)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C385(1.53)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C385(0.99)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C385(0.87)  LDD1530  [3]
 LDCM0293  AC32 HEK-293T C83(0.97)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C385(1.22)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C385(0.91)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C385(1.07)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C385(0.99)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C385(0.92)  LDD1538  [3]
 LDCM0301  AC4 HEK-293T C385(0.93)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C83(0.98)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C385(1.38)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C385(1.18)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C385(1.03)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C385(1.23)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C385(0.96)  LDD1547  [3]
 LDCM0310  AC48 HEK-293T C83(0.88)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C385(1.26)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C385(1.06)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C385(1.02)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C385(0.96)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C385(1.16)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C385(1.01)  LDD1556  [3]
 LDCM0319  AC56 HEK-293T C83(1.07)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C385(1.13)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C385(0.88)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C385(0.88)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C385(1.12)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C385(1.23)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C385(1.01)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C83(1.02)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C83(0.97)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C385(1.13)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C83(0.81)  LDD1514  [3]
 LDCM0368  CL10 HEK-293T C385(0.98)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C385(0.99)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C385(1.09)  LDD1575  [3]
 LDCM0373  CL104 HEK-293T C385(1.17)  LDD1577  [3]
 LDCM0375  CL106 HEK-293T C385(0.85)  LDD1579  [3]
 LDCM0377  CL108 HEK-293T C385(1.05)  LDD1581  [3]
 LDCM0380  CL110 HEK-293T C385(1.10)  LDD1584  [3]
 LDCM0382  CL112 HEK-293T C385(1.64)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C385(1.08)  LDD1588  [3]
 LDCM0386  CL116 HEK-293T C385(1.09)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C385(1.12)  LDD1592  [3]
 LDCM0390  CL12 HEK-293T C83(1.06)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C385(1.00)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C385(0.97)  LDD1597  [3]
 LDCM0395  CL124 HEK-293T C385(1.67)  LDD1599  [3]
 LDCM0397  CL126 HEK-293T C385(0.87)  LDD1601  [3]
 LDCM0399  CL128 HEK-293T C385(1.56)  LDD1603  [3]
 LDCM0401  CL14 HEK-293T C385(0.92)  LDD1605  [3]
 LDCM0403  CL16 HEK-293T C385(1.26)  LDD1607  [3]
 LDCM0405  CL18 HEK-293T C385(0.99)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C385(0.93)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C385(0.94)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C385(1.28)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C385(1.19)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C385(1.02)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C83(0.85)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C385(0.92)  LDD1618  [3]
 LDCM0416  CL28 HEK-293T C385(1.28)  LDD1620  [3]
 LDCM0419  CL30 HEK-293T C385(1.36)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C385(0.94)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C385(1.08)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C385(1.00)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C385(1.25)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C83(1.34)  LDD1629  [3]
 LDCM0429  CL4 HEK-293T C385(1.07)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C385(1.42)  LDD1634  [3]
 LDCM0432  CL42 HEK-293T C385(0.96)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C385(0.94)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C385(1.08)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C385(1.41)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C385(1.00)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C83(1.72)  LDD1642  [3]
 LDCM0441  CL50 HEK-293T C385(1.02)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C385(1.43)  LDD1646  [3]
 LDCM0445  CL54 HEK-293T C385(1.14)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C385(1.09)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C385(1.14)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C385(1.13)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C385(1.06)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C385(0.98)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C83(1.22)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C385(0.94)  LDD1657  [3]
 LDCM0456  CL64 HEK-293T C385(1.28)  LDD1659  [3]
 LDCM0458  CL66 HEK-293T C385(0.91)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C385(1.05)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C385(1.04)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C385(1.36)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C385(0.95)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C385(1.02)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C83(0.72)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C385(1.05)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C385(1.24)  LDD1672  [3]
 LDCM0471  CL78 HEK-293T C385(1.13)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C385(1.14)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C385(0.89)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C385(1.04)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C385(1.22)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C385(0.91)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C83(0.84)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C385(0.94)  LDD1683  [3]
 LDCM0482  CL88 HEK-293T C385(1.05)  LDD1685  [3]
 LDCM0484  CL9 HEK-293T C385(1.13)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C385(1.07)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C385(1.00)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C385(1.16)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C385(1.12)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C385(1.04)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C83(1.74)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C385(0.98)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C385(1.04)  LDD1631  [3]
 LDCM0022  KB02 AN3-CA C83(1.64)  LDD2264  [1]
 LDCM0023  KB03 AN3-CA C83(2.19)  LDD2681  [1]
 LDCM0024  KB05 RL95-2 C83(2.42)  LDD3409  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) Class-II pyridoxal-phosphate-dependent aminotransferase family P13196
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 89 (CCDC89) CCDC89 family Q8N998
KxDL motif-containing protein 1 (KXD1) KXD1 family Q9BQD3
Colorectal mutant cancer protein (MCC) MCC family P23508
Protein SSX7 (SSX7) SSX family Q7RTT5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402