Details of the Target

General Information of Target

Target ID LDTP10063
Target Name Adiponectin receptor protein 1 (ADIPOR1)
Gene Name ADIPOR1
Gene ID 51094
Synonyms
PAQR1; TESBP1A; Adiponectin receptor protein 1; Progestin and adipoQ receptor family member 1; Progestin and adipoQ receptor family member I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFRGLSSWLGLQQPVAGGGQPNGDAPPEQPSETVAESAEEELQQAGDQELLHQAKDFGNY
LFNFASAATKKITESVAETAQTIKKSVEEGKIDGIIDKTIIGDFQKEQKKFVEEQHTKKS
EAAVPPWVDTNDEETIQQQILALSADKRNFLRDPPAGVQFNFDFDQMYPVALVMLQEDEL
LSKMRFALVPKLVKEEVFWRNYFYRVSLIKQSAQLTALAAQQQAAGKEEKSNGREQDLPL
AEAVRPKTPPVVIKSQLKTQEDEEEISTSPGVSEFVSDAFDACNLNQEDLRKEMEQLVLD
KKQEETAVLEEDSADWEKELQQELQEYEVVTESEKRDENWDKEIEKMLQEEN
Target Bioclass
Transporter and channel
Family
ADIPOR family
Subcellular location
Cell membrane
Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin.
Uniprot ID
Q96A54
Ensemble ID
ENST00000340990.10
HGNC ID
HGNC:24040
ChEMBL ID
CHEMBL3392946

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C54(2.21)  LDD0168  [1]
DBIA
 Probe Info  		C54(1.15); C369(0.98)  LDD1492  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C54(2.21)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C54(2.80)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C54(1.58)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C54(0.98)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C54(1.11)  LDD1509  [2]
 LDCM0259  AC14 HEK-293T C54(1.19)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C54(0.87)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C54(1.08)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C54(1.08)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C54(1.04)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C54(1.10)  LDD1518  [2]
 LDCM0281  AC21 HEK-293T C54(0.91)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C54(0.98)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C54(1.00)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C54(1.26)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C54(1.17)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C54(0.95)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C54(0.88)  LDD1526  [2]
 LDCM0289  AC29 HEK-293T C54(1.06)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C54(0.93)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C54(0.89)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C54(0.97)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C54(0.88)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C54(1.01)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C54(0.86)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C54(0.79)  LDD1535  [2]
 LDCM0298  AC37 HEK-293T C54(1.02)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C54(1.10)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C54(0.87)  LDD1539  [2]
 LDCM0302  AC40 HEK-293T C54(1.17)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C54(1.16)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C54(1.10)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C54(0.92)  LDD1544  [2]
 LDCM0307  AC45 HEK-293T C54(1.02)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C54(1.12)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C54(1.03)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C54(1.00)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C54(1.11)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C54(0.96)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C54(0.98)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C54(1.01)  LDD1553  [2]
 LDCM0316  AC53 HEK-293T C54(1.04)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C54(1.06)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C54(1.12)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C54(1.23)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C54(1.30)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C54(0.96)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C54(1.06)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C54(1.02)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C54(0.93)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C54(0.99)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C54(0.97)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C54(0.98)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C54(1.19)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C54(0.78)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C54(0.97)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C54(1.16)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C54(1.41)  LDD1514  [2]
 LDCM0368  CL10 HEK-293T C54(0.85)  LDD1572  [2]
 LDCM0371  CL102 HEK-293T C54(0.91)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C54(1.12)  LDD1576  [2]
 LDCM0375  CL106 HEK-293T C54(0.90)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C54(0.92)  LDD1580  [2]
 LDCM0379  CL11 HEK-293T C54(1.31)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C54(0.85)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C54(1.15)  LDD1585  [2]
 LDCM0384  CL114 HEK-293T C54(0.86)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C54(1.25)  LDD1589  [2]
 LDCM0388  CL118 HEK-293T C54(1.01)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C54(1.10)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C54(0.96)  LDD1594  [2]
 LDCM0393  CL122 HEK-293T C54(0.94)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C54(0.89)  LDD1598  [2]
 LDCM0397  CL126 HEK-293T C54(0.99)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C54(1.04)  LDD1602  [2]
 LDCM0401  CL14 HEK-293T C54(0.84)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C54(1.14)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C54(1.14)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C54(1.05)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C54(0.83)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C54(0.93)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C54(1.04)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C54(1.32)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C54(1.36)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C54(1.13)  LDD1616  [2]
 LDCM0414  CL26 HEK-293T C54(1.06)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C54(0.76)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C54(1.09)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C54(0.89)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C54(0.98)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C54(0.68)  LDD1624  [2]
 LDCM0422  CL33 HEK-293T C54(1.02)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C54(1.01)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C54(1.17)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C54(1.24)  LDD1629  [2]
 LDCM0428  CL39 HEK-293T C54(0.74)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C54(1.18)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C54(0.91)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C54(1.06)  LDD1637  [2]
 LDCM0435  CL45 HEK-293T C54(0.93)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C54(0.99)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C54(0.81)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C54(1.42)  LDD1642  [2]
 LDCM0440  CL5 HEK-293T C54(1.18)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C54(0.76)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C54(1.10)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C54(0.92)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C54(1.66)  LDD1649  [2]
 LDCM0448  CL57 HEK-293T C54(1.04)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C54(0.95)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C54(0.99)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C54(0.90)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C54(1.22)  LDD1655  [2]
 LDCM0454  CL62 HEK-293T C54(0.84)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C54(0.87)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C54(1.36)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C54(1.18)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C54(0.74)  LDD1662  [2]
 LDCM0461  CL69 HEK-293T C54(1.02)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C54(1.09)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C54(1.22)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C54(1.45)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C54(1.53)  LDD1668  [2]
 LDCM0467  CL74 HEK-293T C54(0.94)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C54(0.96)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C54(1.03)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C54(0.90)  LDD1675  [2]
 LDCM0475  CL81 HEK-293T C54(1.03)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C54(0.85)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C54(1.55)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C54(1.14)  LDD1681  [2]
 LDCM0480  CL86 HEK-293T C54(1.12)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C54(0.99)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C54(1.10)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C54(1.02)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C54(1.01)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C54(0.77)  LDD1689  [2]
 LDCM0488  CL93 HEK-293T C54(0.96)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C54(1.14)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C54(0.81)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C54(0.75)  LDD1694  [2]
 LDCM0493  CL98 HEK-293T C54(0.92)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C54(1.06)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C54(0.92)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C54(0.90)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C54(0.99)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C54(1.15); C369(0.98)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C54(1.14); C369(1.05)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C54(1.56); C369(0.98)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adiponectin receptor protein 1 (ADIPOR1) ADIPOR family Q96A54
Toll-like receptor 4 (TLR4) Toll-like receptor family O00206
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DCC-interacting protein 13-alpha (APPL1) . Q9UKG1

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004