Details of the Target

General Information of Target

Target ID LDTP10043
Target Name RILP-like protein 2 (RILPL2)
Gene Name RILPL2
Gene ID 196383
Synonyms
RLP2; RILP-like protein 2; Rab-interacting lysosomal protein-like 2; p40phox-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITC
LLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLA
VPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNR
ESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYP
GSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL
Target Bioclass
Other
Family
RILPL family
Subcellular location
Cytoplasm, cytosol
Function
Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1.
Uniprot ID
Q969X0
Ensemble ID
ENST00000280571.10
HGNC ID
HGNC:28787

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K201(6.67)  LDD0277  [1]
DBIA
 Probe Info  		C161(1.74)  LDD3334  [2]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 PaTu 8988t C161(0.69)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C161(1.00)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C161(0.92)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C161(1.07)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C161(0.88)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C161(1.02)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C161(1.37)  LDD1115  [4]
 LDCM0238  AC120 PaTu 8988t C161(1.01)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C161(1.38)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C161(1.12)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C161(0.80)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C161(1.44)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C161(1.07)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C161(0.81)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C161(1.18)  LDD1124  [4]
 LDCM0246  AC128 PaTu 8988t C161(1.13)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C161(1.07)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C161(1.07)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C161(1.02)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C161(1.12)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C161(1.46)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C161(1.24)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C161(1.57)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C161(1.52)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C161(1.57)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C161(1.28)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C161(1.17)  LDD1137  [4]
 LDCM0260  AC140 PaTu 8988t C161(1.06)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C161(0.96)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C161(1.09)  LDD1141  [4]
 LDCM0263  AC143 PaTu 8988t C161(1.06)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C161(1.07)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C161(1.16)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C161(0.93)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C161(0.86)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C161(1.11)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C161(1.46)  LDD1148  [4]
 LDCM0271  AC150 PaTu 8988t C161(1.27)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C161(1.96)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C161(1.36)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C161(1.35)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C161(1.49)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C161(1.61)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C161(1.73)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C161(1.36)  LDD2169  [4]
 LDCM0285  AC25 PaTu 8988t C161(0.89)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C161(1.11)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C161(1.10)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C161(1.19)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C161(1.10)  LDD1168  [4]
 LDCM0291  AC30 PaTu 8988t C161(1.14)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C161(1.09)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C161(1.09)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C161(1.21)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C161(1.46)  LDD1174  [4]
 LDCM0332  AC68 PaTu 8988t C161(0.88)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C161(0.97)  LDD1212  [4]
 LDCM0335  AC70 PaTu 8988t C161(0.98)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C161(0.91)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C161(0.80)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C161(0.88)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C161(0.93)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C161(1.00)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C161(0.86)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C161(0.84)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C161(1.03)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C161(1.06)  LDD1223  [4]
 LDCM0346  AC80 PaTu 8988t C161(0.89)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C161(0.85)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C161(1.07)  LDD1227  [4]
 LDCM0367  CL1 PaTu 8988t C161(0.93)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C161(0.97)  LDD1247  [4]
 LDCM0379  CL11 PaTu 8988t C161(0.95)  LDD1258  [4]
 LDCM0382  CL112 PaTu 8988t C161(1.00)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C161(0.98)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C161(1.02)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C161(0.98)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C161(1.10)  LDD1265  [4]
 LDCM0390  CL12 PaTu 8988t C161(1.00)  LDD1269  [4]
 LDCM0400  CL13 PaTu 8988t C161(1.11)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C161(1.06)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C161(1.04)  LDD1281  [4]
 LDCM0407  CL2 PaTu 8988t C161(0.90)  LDD1286  [4]
 LDCM0418  CL3 PaTu 8988t C161(0.99)  LDD1297  [4]
 LDCM0420  CL31 PaTu 8988t C161(1.11)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C161(1.08)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C161(0.99)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C161(1.20)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C161(1.48)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C161(0.61)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C161(1.22)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C161(1.09)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C161(0.90)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C161(1.19)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C161(1.19)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C161(1.23)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C161(1.27)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C161(1.44)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C161(1.33)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C161(1.05)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C161(1.05)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C161(0.99)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C161(1.23)  LDD1318  [4]
 LDCM0440  CL5 PaTu 8988t C161(1.01)  LDD1319  [4]
 LDCM0441  CL50 PaTu 8988t C161(1.12)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C161(1.16)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C161(1.26)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C161(1.24)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C161(1.11)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C161(1.13)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C161(1.23)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C161(1.17)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C161(1.21)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C161(1.11)  LDD1329  [4]
 LDCM0451  CL6 PaTu 8988t C161(0.92)  LDD1330  [4]
 LDCM0452  CL60 PaTu 8988t C161(0.98)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C161(1.04)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C161(1.26)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C161(1.27)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C161(1.35)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C161(1.25)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C161(1.20)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C161(1.28)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C161(1.32)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C161(1.49)  LDD1340  [4]
 LDCM0462  CL7 PaTu 8988t C161(1.04)  LDD1341  [4]
 LDCM0463  CL70 PaTu 8988t C161(1.45)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C161(1.21)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C161(1.24)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C161(1.59)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C161(1.26)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C161(1.01)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C161(1.03)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C161(1.15)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C161(1.20)  LDD1351  [4]
 LDCM0473  CL8 PaTu 8988t C161(0.91)  LDD1352  [4]
 LDCM0474  CL80 PaTu 8988t C161(1.12)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C161(1.32)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C161(1.35)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C161(1.29)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C161(0.91)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C161(1.15)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C161(1.32)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C161(1.27)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C161(1.32)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C161(1.01)  LDD1362  [4]
 LDCM0484  CL9 PaTu 8988t C161(0.99)  LDD1363  [4]
 LDCM0485  CL90 PaTu 8988t C161(1.16)  LDD1364  [4]
 LDCM0468  Fragment33 PaTu 8988t C161(1.44)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C161(1.30)  LDD1306  [4]
 LDCM0022  KB02 CMK C161(1.51)  LDD2302  [2]
 LDCM0023  KB03 CMK C161(1.93)  LDD2719  [2]
 LDCM0024  KB05 MOLM-16 C161(1.74)  LDD3334  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.