Details of the Target
General Information of Target
Target ID | LDTP09942 | |||||
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Target Name | Potassium voltage-gated channel subfamily B member 2 (KCNB2) | |||||
Gene Name | KCNB2 | |||||
Gene ID | 9312 | |||||
Synonyms |
Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2 |
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3D Structure | ||||||
Sequence |
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPR
GQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVV MVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIA MTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYL LGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTAL VVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARV RKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEA RLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPS DCG |
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Target Type |
Literature-reported
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Target Bioclass |
Transporter and channel
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Family |
Potassium channel family, B (Shab) (TC 1.A.1.2) subfamily, Kv2.2/KCNB2 sub-subfamily
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Subcellular location |
Cell membrane
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Function |
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
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TTD ID | ||||||
Uniprot ID | ||||||
DrugMap ID | ||||||
Ensemble ID | ||||||
HGNC ID | ||||||
ChEMBL ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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DBIA Probe Info |
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C883(0.84) | LDD1492 | [1] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0214 | AC1 | HEK-293T | C883(1.09) | LDD1507 | [1] |
LDCM0226 | AC11 | HEK-293T | C883(1.08) | LDD1509 | [1] |
LDCM0237 | AC12 | HEK-293T | C883(0.86) | LDD1510 | [1] |
LDCM0270 | AC15 | HEK-293T | C883(0.99) | LDD1513 | [1] |
LDCM0276 | AC17 | HEK-293T | C883(1.06) | LDD1515 | [1] |
LDCM0278 | AC19 | HEK-293T | C883(1.33) | LDD1517 | [1] |
LDCM0280 | AC20 | HEK-293T | C883(0.75) | LDD1519 | [1] |
LDCM0283 | AC23 | HEK-293T | C883(0.99) | LDD1522 | [1] |
LDCM0284 | AC24 | HEK-293T | C560(0.95) | LDD1523 | [1] |
LDCM0285 | AC25 | HEK-293T | C883(0.99) | LDD1524 | [1] |
LDCM0287 | AC27 | HEK-293T | C883(1.05) | LDD1526 | [1] |
LDCM0288 | AC28 | HEK-293T | C883(1.09) | LDD1527 | [1] |
LDCM0290 | AC3 | HEK-293T | C883(1.04) | LDD1529 | [1] |
LDCM0292 | AC31 | HEK-293T | C883(0.92) | LDD1531 | [1] |
LDCM0293 | AC32 | HEK-293T | C560(0.78) | LDD1532 | [1] |
LDCM0294 | AC33 | HEK-293T | C883(0.96) | LDD1533 | [1] |
LDCM0296 | AC35 | HEK-293T | C883(1.18) | LDD1535 | [1] |
LDCM0297 | AC36 | HEK-293T | C883(0.76) | LDD1536 | [1] |
LDCM0300 | AC39 | HEK-293T | C883(1.13) | LDD1539 | [1] |
LDCM0301 | AC4 | HEK-293T | C883(0.81) | LDD1540 | [1] |
LDCM0302 | AC40 | HEK-293T | C560(0.85) | LDD1541 | [1] |
LDCM0303 | AC41 | HEK-293T | C883(0.95) | LDD1542 | [1] |
LDCM0305 | AC43 | HEK-293T | C883(1.23) | LDD1544 | [1] |
LDCM0306 | AC44 | HEK-293T | C883(0.93) | LDD1545 | [1] |
LDCM0309 | AC47 | HEK-293T | C883(1.31) | LDD1548 | [1] |
LDCM0310 | AC48 | HEK-293T | C560(0.90) | LDD1549 | [1] |
LDCM0311 | AC49 | HEK-293T | C883(0.99) | LDD1550 | [1] |
LDCM0314 | AC51 | HEK-293T | C883(1.04) | LDD1553 | [1] |
LDCM0315 | AC52 | HEK-293T | C883(0.96) | LDD1554 | [1] |
LDCM0318 | AC55 | HEK-293T | C883(1.25) | LDD1557 | [1] |
LDCM0319 | AC56 | HEK-293T | C560(0.88) | LDD1558 | [1] |
LDCM0320 | AC57 | HEK-293T | C883(1.05) | LDD1559 | [1] |
LDCM0322 | AC59 | HEK-293T | C883(1.11) | LDD1561 | [1] |
LDCM0324 | AC60 | HEK-293T | C883(0.86) | LDD1563 | [1] |
LDCM0327 | AC63 | HEK-293T | C883(1.22) | LDD1566 | [1] |
LDCM0328 | AC64 | HEK-293T | C560(0.95) | LDD1567 | [1] |
LDCM0334 | AC7 | HEK-293T | C883(1.14) | LDD1568 | [1] |
LDCM0345 | AC8 | HEK-293T | C560(0.91) | LDD1569 | [1] |
LDCM0356 | AKOS034007680 | HEK-293T | C883(1.02) | LDD1570 | [1] |
LDCM0275 | AKOS034007705 | HEK-293T | C560(0.77) | LDD1514 | [1] |
LDCM0369 | CL100 | HEK-293T | C560(0.89) | LDD1573 | [1] |
LDCM0371 | CL102 | HEK-293T | C883(1.09) | LDD1575 | [1] |
LDCM0373 | CL104 | HEK-293T | C560(1.18) | LDD1577 | [1] |
LDCM0375 | CL106 | HEK-293T | C883(1.08) | LDD1579 | [1] |
LDCM0377 | CL108 | HEK-293T | C560(0.91) | LDD1581 | [1] |
LDCM0379 | CL11 | HEK-293T | C883(1.42) | LDD1583 | [1] |
LDCM0380 | CL110 | HEK-293T | C883(0.97) | LDD1584 | [1] |
LDCM0382 | CL112 | HEK-293T | C560(0.95) | LDD1586 | [1] |
LDCM0384 | CL114 | HEK-293T | C883(1.16) | LDD1588 | [1] |
LDCM0386 | CL116 | HEK-293T | C560(1.29) | LDD1590 | [1] |
LDCM0388 | CL118 | HEK-293T | C883(1.13) | LDD1592 | [1] |
LDCM0390 | CL12 | HEK-293T | C560(1.58) | LDD1594 | [1] |
LDCM0391 | CL120 | HEK-293T | C560(1.73) | LDD1595 | [1] |
LDCM0393 | CL122 | HEK-293T | C883(1.06) | LDD1597 | [1] |
LDCM0395 | CL124 | HEK-293T | C560(1.04) | LDD1599 | [1] |
LDCM0397 | CL126 | HEK-293T | C883(1.11) | LDD1601 | [1] |
LDCM0399 | CL128 | HEK-293T | C560(1.18) | LDD1603 | [1] |
LDCM0401 | CL14 | HEK-293T | C883(0.98) | LDD1605 | [1] |
LDCM0403 | CL16 | HEK-293T | C560(0.94) | LDD1607 | [1] |
LDCM0404 | CL17 | HEK-293T | C883(1.12) | LDD1608 | [1] |
LDCM0406 | CL19 | HEK-293T | C883(1.06) | LDD1610 | [1] |
LDCM0407 | CL2 | HEK-293T | C883(1.10) | LDD1611 | [1] |
LDCM0408 | CL20 | HEK-293T | C883(1.15) | LDD1612 | [1] |
LDCM0411 | CL23 | HEK-293T | C883(1.04) | LDD1615 | [1] |
LDCM0412 | CL24 | HEK-293T | C560(1.48) | LDD1616 | [1] |
LDCM0414 | CL26 | HEK-293T | C883(1.20) | LDD1618 | [1] |
LDCM0416 | CL28 | HEK-293T | C560(0.97) | LDD1620 | [1] |
LDCM0417 | CL29 | HEK-293T | C883(0.88) | LDD1621 | [1] |
LDCM0420 | CL31 | HEK-293T | C883(0.99) | LDD1624 | [1] |
LDCM0421 | CL32 | HEK-293T | C883(0.76) | LDD1625 | [1] |
LDCM0424 | CL35 | HEK-293T | C883(0.97) | LDD1628 | [1] |
LDCM0425 | CL36 | HEK-293T | C560(1.56) | LDD1629 | [1] |
LDCM0429 | CL4 | HEK-293T | C560(1.22) | LDD1633 | [1] |
LDCM0430 | CL40 | HEK-293T | C560(0.95) | LDD1634 | [1] |
LDCM0431 | CL41 | HEK-293T | C883(1.09) | LDD1635 | [1] |
LDCM0433 | CL43 | HEK-293T | C883(0.94) | LDD1637 | [1] |
LDCM0434 | CL44 | HEK-293T | C883(1.42) | LDD1638 | [1] |
LDCM0437 | CL47 | HEK-293T | C883(1.25) | LDD1641 | [1] |
LDCM0438 | CL48 | HEK-293T | C560(2.07) | LDD1642 | [1] |
LDCM0440 | CL5 | HEK-293T | C883(1.21) | LDD1644 | [1] |
LDCM0441 | CL50 | HEK-293T | C883(1.24) | LDD1645 | [1] |
LDCM0443 | CL52 | HEK-293T | C560(0.94) | LDD1646 | [1] |
LDCM0444 | CL53 | HEK-293T | C883(1.06) | LDD1647 | [1] |
LDCM0446 | CL55 | HEK-293T | C883(1.17) | LDD1649 | [1] |
LDCM0447 | CL56 | HEK-293T | C883(0.87) | LDD1650 | [1] |
LDCM0450 | CL59 | HEK-293T | C883(1.72) | LDD1653 | [1] |
LDCM0452 | CL60 | HEK-293T | C560(1.58) | LDD1655 | [1] |
LDCM0454 | CL62 | HEK-293T | C883(1.07) | LDD1657 | [1] |
LDCM0456 | CL64 | HEK-293T | C560(0.94) | LDD1659 | [1] |
LDCM0457 | CL65 | HEK-293T | C883(0.98) | LDD1660 | [1] |
LDCM0459 | CL67 | HEK-293T | C883(1.06) | LDD1662 | [1] |
LDCM0460 | CL68 | HEK-293T | C883(1.24) | LDD1663 | [1] |
LDCM0462 | CL7 | HEK-293T | C883(1.33) | LDD1665 | [1] |
LDCM0464 | CL71 | HEK-293T | C883(1.29) | LDD1667 | [1] |
LDCM0465 | CL72 | HEK-293T | C560(1.52) | LDD1668 | [1] |
LDCM0467 | CL74 | HEK-293T | C883(1.07) | LDD1670 | [1] |
LDCM0469 | CL76 | HEK-293T | C560(1.21) | LDD1672 | [1] |
LDCM0470 | CL77 | HEK-293T | C883(1.10) | LDD1673 | [1] |
LDCM0472 | CL79 | HEK-293T | C883(1.24) | LDD1675 | [1] |
LDCM0473 | CL8 | HEK-293T | C883(0.79) | LDD1676 | [1] |
LDCM0474 | CL80 | HEK-293T | C883(1.32) | LDD1677 | [1] |
LDCM0477 | CL83 | HEK-293T | C883(0.89) | LDD1680 | [1] |
LDCM0478 | CL84 | HEK-293T | C560(1.29) | LDD1681 | [1] |
LDCM0480 | CL86 | HEK-293T | C883(0.98) | LDD1683 | [1] |
LDCM0482 | CL88 | HEK-293T | C560(1.38) | LDD1685 | [1] |
LDCM0483 | CL89 | HEK-293T | C883(0.98) | LDD1686 | [1] |
LDCM0486 | CL91 | HEK-293T | C883(1.18) | LDD1689 | [1] |
LDCM0487 | CL92 | HEK-293T | C883(1.06) | LDD1690 | [1] |
LDCM0490 | CL95 | HEK-293T | C883(1.38) | LDD1693 | [1] |
LDCM0491 | CL96 | HEK-293T | C560(1.06) | LDD1694 | [1] |
LDCM0493 | CL98 | HEK-293T | C883(1.11) | LDD1696 | [1] |
LDCM0427 | Fragment51 | HEK-293T | C883(1.01) | LDD1631 | [1] |
LDCM0022 | KB02 | HEK-293T | C883(0.84) | LDD1492 | [1] |
LDCM0023 | KB03 | HEK-293T | C883(0.79) | LDD1497 | [1] |
LDCM0024 | KB05 | HEK-293T | C883(0.99) | LDD1502 | [1] |
The Interaction Atlas With This Target
The Drug(s) Related To This Target
Approved
Drug Name | Drug Type | External ID | |||
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Dalfampridine | Small molecular drug | DB06637 | |||
Enflurane | Small molecular drug | DB00228 | |||
Miconazole | Small molecular drug | DB01110 | |||
Promethazine | Small molecular drug | DB01069 |
Investigative
Drug Name | Drug Type | External ID | |||
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Ry796 | Small molecular drug | D0I7VY | |||
[14c]Tea | Small molecular drug | D06PZZ |