General Information of Target

Target ID LDTP09942
Target Name Potassium voltage-gated channel subfamily B member 2 (KCNB2)
Gene Name KCNB2
Gene ID 9312
Synonyms
Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPR
GQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVV
MVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIA
MTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYL
LGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWT
VRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTAL
VVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARV
RKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEA
RLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPS
DCG
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Potassium channel family, B (Shab) (TC 1.A.1.2) subfamily, Kv2.2/KCNB2 sub-subfamily
Subcellular location
Cell membrane
Function
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
TTD ID
T65932
Uniprot ID
Q92953
DrugMap ID
TT5PFNG
Ensemble ID
ENST00000523207.2
HGNC ID
HGNC:6232
ChEMBL ID
CHEMBL2321618

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C883(0.84)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C883(1.09)  LDD1507  [1]
 LDCM0226  AC11 HEK-293T C883(1.08)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C883(0.86)  LDD1510  [1]
 LDCM0270  AC15 HEK-293T C883(0.99)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C883(1.06)  LDD1515  [1]
 LDCM0278  AC19 HEK-293T C883(1.33)  LDD1517  [1]
 LDCM0280  AC20 HEK-293T C883(0.75)  LDD1519  [1]
 LDCM0283  AC23 HEK-293T C883(0.99)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C560(0.95)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C883(0.99)  LDD1524  [1]
 LDCM0287  AC27 HEK-293T C883(1.05)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C883(1.09)  LDD1527  [1]
 LDCM0290  AC3 HEK-293T C883(1.04)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C883(0.92)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C560(0.78)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C883(0.96)  LDD1533  [1]
 LDCM0296  AC35 HEK-293T C883(1.18)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C883(0.76)  LDD1536  [1]
 LDCM0300  AC39 HEK-293T C883(1.13)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C883(0.81)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C560(0.85)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C883(0.95)  LDD1542  [1]
 LDCM0305  AC43 HEK-293T C883(1.23)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C883(0.93)  LDD1545  [1]
 LDCM0309  AC47 HEK-293T C883(1.31)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C560(0.90)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C883(0.99)  LDD1550  [1]
 LDCM0314  AC51 HEK-293T C883(1.04)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C883(0.96)  LDD1554  [1]
 LDCM0318  AC55 HEK-293T C883(1.25)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C560(0.88)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C883(1.05)  LDD1559  [1]
 LDCM0322  AC59 HEK-293T C883(1.11)  LDD1561  [1]
 LDCM0324  AC60 HEK-293T C883(0.86)  LDD1563  [1]
 LDCM0327  AC63 HEK-293T C883(1.22)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C560(0.95)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C883(1.14)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C560(0.91)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C883(1.02)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C560(0.77)  LDD1514  [1]
 LDCM0369  CL100 HEK-293T C560(0.89)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C883(1.09)  LDD1575  [1]
 LDCM0373  CL104 HEK-293T C560(1.18)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C883(1.08)  LDD1579  [1]
 LDCM0377  CL108 HEK-293T C560(0.91)  LDD1581  [1]
 LDCM0379  CL11 HEK-293T C883(1.42)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C883(0.97)  LDD1584  [1]
 LDCM0382  CL112 HEK-293T C560(0.95)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C883(1.16)  LDD1588  [1]
 LDCM0386  CL116 HEK-293T C560(1.29)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C883(1.13)  LDD1592  [1]
 LDCM0390  CL12 HEK-293T C560(1.58)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C560(1.73)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C883(1.06)  LDD1597  [1]
 LDCM0395  CL124 HEK-293T C560(1.04)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C883(1.11)  LDD1601  [1]
 LDCM0399  CL128 HEK-293T C560(1.18)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C883(0.98)  LDD1605  [1]
 LDCM0403  CL16 HEK-293T C560(0.94)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C883(1.12)  LDD1608  [1]
 LDCM0406  CL19 HEK-293T C883(1.06)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C883(1.10)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C883(1.15)  LDD1612  [1]
 LDCM0411  CL23 HEK-293T C883(1.04)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C560(1.48)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C883(1.20)  LDD1618  [1]
 LDCM0416  CL28 HEK-293T C560(0.97)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C883(0.88)  LDD1621  [1]
 LDCM0420  CL31 HEK-293T C883(0.99)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C883(0.76)  LDD1625  [1]
 LDCM0424  CL35 HEK-293T C883(0.97)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C560(1.56)  LDD1629  [1]
 LDCM0429  CL4 HEK-293T C560(1.22)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C560(0.95)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C883(1.09)  LDD1635  [1]
 LDCM0433  CL43 HEK-293T C883(0.94)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C883(1.42)  LDD1638  [1]
 LDCM0437  CL47 HEK-293T C883(1.25)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C560(2.07)  LDD1642  [1]
 LDCM0440  CL5 HEK-293T C883(1.21)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C883(1.24)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C560(0.94)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C883(1.06)  LDD1647  [1]
 LDCM0446  CL55 HEK-293T C883(1.17)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C883(0.87)  LDD1650  [1]
 LDCM0450  CL59 HEK-293T C883(1.72)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C560(1.58)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C883(1.07)  LDD1657  [1]
 LDCM0456  CL64 HEK-293T C560(0.94)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C883(0.98)  LDD1660  [1]
 LDCM0459  CL67 HEK-293T C883(1.06)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C883(1.24)  LDD1663  [1]
 LDCM0462  CL7 HEK-293T C883(1.33)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C883(1.29)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C560(1.52)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C883(1.07)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C560(1.21)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C883(1.10)  LDD1673  [1]
 LDCM0472  CL79 HEK-293T C883(1.24)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C883(0.79)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C883(1.32)  LDD1677  [1]
 LDCM0477  CL83 HEK-293T C883(0.89)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C560(1.29)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C883(0.98)  LDD1683  [1]
 LDCM0482  CL88 HEK-293T C560(1.38)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C883(0.98)  LDD1686  [1]
 LDCM0486  CL91 HEK-293T C883(1.18)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C883(1.06)  LDD1690  [1]
 LDCM0490  CL95 HEK-293T C883(1.38)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C560(1.06)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C883(1.11)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C883(1.01)  LDD1631  [1]
 LDCM0022  KB02 HEK-293T C883(0.84)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C883(0.79)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C883(0.99)  LDD1502  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dalfampridine Small molecular drug DB06637
Enflurane Small molecular drug DB00228
Miconazole Small molecular drug DB01110
Promethazine Small molecular drug DB01069
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ry796 Small molecular drug D0I7VY
[14c]Tea Small molecular drug D06PZZ

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402