Details of the Target

General Information of Target

Target ID LDTP09873
Target Name Prospero homeobox protein 1 (PROX1)
Gene Name PROX1
Gene ID 5629
Synonyms
Prospero homeobox protein 1; Homeobox prospero-like protein PROX1; PROX-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVVENVVKLLGEQYYKDAMEQCHNYNARLCAERSVRLPFLDSQTGVAQSNCYIWMEKR
HRGPGLASGQLYSYPARRWRKKRRAHPPEDPRLSFPSIKPDTDQTLKKEGLISQDGSSLE
ALLRTDPLEKRGAPDPRVDDDSLGEFPVTNSRARKRILEPDDFLDDLDDEDYEEDTPKRR
GKGKSKGKGVGSARKKLDASILEDRDKPYACDICGKRYKNRPGLSYHYAHSHLAEEEGED
KEDSQPPTPVSQRSEEQKSKKGPDGLALPNNYCDFCLGDSKINKKTGQPEELVSCSDCGR
SGHPSCLQFTPVMMAAVKTYRWQCIECKCCNICGTSENDDQLLFCDDCDRGYHMYCLTPS
MSEPPEGSWSCHLCLDLLKEKASIYQNQNSS
Target Bioclass
Transcription factor
Family
Prospero homeodomain family
Subcellular location
Nucleus
Function
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
Uniprot ID
Q92786
Ensemble ID
ENST00000366958.9
HGNC ID
HGNC:9459

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C158(0.00); C615(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C615(2.04)  LDD3333  [2]
W1
 Probe Info  		C300(0.00); C158(0.00)  LDD0236  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C158(0.93)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C158(0.91)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C158(0.90)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C158(0.98)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C158(0.94)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C158(1.03)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C158(0.95)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C158(0.93)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C158(1.10)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C158(0.83)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C158(1.01)  LDD1519  [3]
 LDCM0282  AC22 HEK-293T C158(1.00)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C158(0.93)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C158(1.01)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C158(0.95)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C158(0.89)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C158(0.98)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C158(0.88)  LDD1527  [3]
 LDCM0290  AC3 HEK-293T C158(0.96)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C158(0.98)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C158(1.01)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C158(0.90)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C158(0.97)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C158(0.83)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C158(0.99)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C158(0.89)  LDD1536  [3]
 LDCM0299  AC38 HEK-293T C158(1.01)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C158(1.03)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C158(0.99)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C158(0.92)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C158(0.95)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C158(0.86)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C158(0.99)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C158(0.89)  LDD1545  [3]
 LDCM0308  AC46 HEK-293T C158(1.01)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C158(1.15)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C158(0.95)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C158(0.95)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C158(0.87)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C158(0.93)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C158(0.90)  LDD1554  [3]
 LDCM0317  AC54 HEK-293T C158(1.03)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C158(1.02)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C158(0.99)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C158(0.91)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C158(0.88)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C158(0.99)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C158(1.19)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C158(0.98)  LDD1563  [3]
 LDCM0326  AC62 HEK-293T C158(0.98)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C158(1.14)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C158(0.91)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C158(1.12)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C158(0.92)  LDD1569  [3]
 LDCM0356  AKOS034007680 HEK-293T C158(1.03)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C158(0.98)  LDD1514  [3]
 LDCM0368  CL10 HEK-293T C158(1.11)  LDD1572  [3]
 LDCM0371  CL102 HEK-293T C158(1.05)  LDD1575  [3]
 LDCM0375  CL106 HEK-293T C158(1.02)  LDD1579  [3]
 LDCM0379  CL11 HEK-293T C158(1.19)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C158(1.08)  LDD1584  [3]
 LDCM0384  CL114 HEK-293T C158(1.05)  LDD1588  [3]
 LDCM0388  CL118 HEK-293T C158(1.04)  LDD1592  [3]
 LDCM0390  CL12 HEK-293T C158(0.89)  LDD1594  [3]
 LDCM0393  CL122 HEK-293T C158(1.02)  LDD1597  [3]
 LDCM0397  CL126 HEK-293T C158(1.02)  LDD1601  [3]
 LDCM0401  CL14 HEK-293T C158(1.07)  LDD1605  [3]
 LDCM0404  CL17 HEK-293T C158(0.95)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C158(0.92)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C158(0.92)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C158(0.98)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C158(0.90)  LDD1612  [3]
 LDCM0410  CL22 HEK-293T C158(0.97)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C158(1.14)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C158(0.84)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C158(1.05)  LDD1618  [3]
 LDCM0417  CL29 HEK-293T C158(1.02)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C158(0.95)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C158(1.02)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C158(0.89)  LDD1625  [3]
 LDCM0423  CL34 HEK-293T C158(0.89)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C158(1.03)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C158(1.00)  LDD1629  [3]
 LDCM0431  CL41 HEK-293T C158(0.95)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C158(1.01)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C158(0.90)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C158(0.92)  LDD1638  [3]
 LDCM0436  CL46 HEK-293T C158(0.89)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C158(1.02)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C158(0.83)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C158(0.88)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C158(1.07)  LDD1645  [3]
 LDCM0444  CL53 HEK-293T C158(0.91)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C158(0.79)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C158(0.92)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C158(0.98)  LDD1650  [3]
 LDCM0449  CL58 HEK-293T C158(0.97)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C158(1.00)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C158(0.83)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C158(0.98)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C158(1.03)  LDD1657  [3]
 LDCM0457  CL65 HEK-293T C158(0.92)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C158(0.92)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C158(0.89)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C158(0.92)  LDD1663  [3]
 LDCM0462  CL7 HEK-293T C158(0.89)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C158(1.01)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C158(1.11)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C158(1.02)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C158(0.97)  LDD1670  [3]
 LDCM0470  CL77 HEK-293T C158(0.99)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C158(0.90)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C158(0.89)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C158(1.13)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C158(0.97)  LDD1677  [3]
 LDCM0476  CL82 HEK-293T C158(1.05)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C158(1.00)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C158(0.95)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C158(0.99)  LDD1683  [3]
 LDCM0483  CL89 HEK-293T C158(0.90)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C158(0.89)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C158(0.91)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C158(0.92)  LDD1690  [3]
 LDCM0489  CL94 HEK-293T C158(0.99)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C158(1.12)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C158(0.94)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C158(1.03)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C158(0.94)  LDD1631  [3]
 LDCM0022  KB02 769-P C158(2.31)  LDD2246  [2]
 LDCM0023  KB03 769-P C158(2.95)  LDD2663  [2]
 LDCM0024  KB05 MOLM-13 C615(2.04)  LDD3333  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-terminal-binding protein 2 (CTBP2) D-isomer specific 2-hydroxyacid dehydrogenase family P56545
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte nuclear factor 1-alpha (HNF1A) HNF1 homeobox family P20823
Hepatocyte nuclear factor 4-alpha (HNF4A) Nuclear hormone receptor family P41235

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402