Details of the Target

General Information of Target

Target ID LDTP09827
Target Name Amyloid protein-binding protein 2 (APPBP2)
Gene Name APPBP2
Gene ID 10513
Synonyms
KIAA0228; PAT1; Amyloid protein-binding protein 2; Amyloid beta precursor protein-binding protein 2; APP-BP2; Protein interacting with APP tail 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRD
MQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERA
VAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNP
RLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNN
GSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLT
SPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQ
KPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP
ESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSE
QDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIR
LRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIR
RNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQK
LLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYR
CAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDL
LIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVP
GHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDI
IFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAE
ALALEAAVLEAT
Target Bioclass
Other
Subcellular location
Nucleus
Function
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface.
Uniprot ID
Q92624
Ensemble ID
ENST00000083182.8
HGNC ID
HGNC:622

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C393(1.80)  LDD3340  [1]
IA-alkyne
 Probe Info  		C54(19.85)  LDD1703  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
NAIA_5
 Probe Info  		C213(0.00); C393(0.00); C105(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C229(0.79); C213(1.13)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C229(1.30); C213(1.09)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C213(0.98)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C213(0.93)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C213(0.94)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C393(1.08); C213(0.98)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C229(0.74); C213(0.95)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C229(0.97); C213(0.87)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C213(1.04)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C229(1.21); C213(1.03)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C213(1.04)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C393(1.01); C229(0.81); C213(0.88)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C213(0.98)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C393(1.01); C213(0.88)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C393(1.01); C213(1.20)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C229(0.84); C213(0.96)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C229(0.95); C213(1.01)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C213(1.01)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C213(1.00)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C393(1.02); C229(0.89); C213(0.97)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C213(1.01)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C213(0.90)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C393(1.09); C213(1.01)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C393(1.04); C213(1.00)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C229(0.82); C213(0.98)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C229(1.11); C213(0.91)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C213(1.05)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C213(1.03)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C393(1.07); C229(0.92); C213(0.88)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C213(0.88)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C393(1.12); C213(0.97)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C213(1.09)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C393(1.13); C213(0.90)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C229(0.84); C213(1.08)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C229(1.10); C213(1.00)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C213(1.09)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C213(0.89)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C393(1.17); C229(0.93); C213(0.93)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C213(0.82)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C393(1.10); C213(1.09)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C393(1.01); C213(0.92)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C229(0.97); C213(1.08)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C393(1.08); C229(0.93); C213(0.91)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C229(1.16); C213(1.02)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C213(1.05)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C213(1.17)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C393(1.08); C229(0.88); C213(0.98)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C213(1.15)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C393(1.06); C213(0.93)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C393(1.09); C213(1.12)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C229(0.83); C213(1.02)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C229(1.08); C213(1.07)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C213(1.05)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C213(1.02)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C213(1.15)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C393(1.05); C229(0.99); C213(0.96)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C213(0.99)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C393(1.14); C213(1.09)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C393(0.99); C213(0.99)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C393(0.97); C213(0.87)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C393(1.06); C213(1.11)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C393(1.07); C229(0.92); C213(0.87)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C229(0.73); C213(0.90)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C393(1.09); C213(1.01)  LDD1514  [6]
 LDCM0632  CL-Sc Hep-G2 C54(0.43)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C393(1.06)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C213(1.07)  LDD1572  [6]
 LDCM0370  CL101 HEK-293T C393(1.05)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C393(1.07); C229(0.95)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C229(0.86); C213(0.92); C54(1.20)  LDD1576  [6]
 LDCM0374  CL105 HEK-293T C393(0.98)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C393(0.98); C229(0.79)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C229(0.74); C213(0.95); C54(1.26)  LDD1580  [6]
 LDCM0378  CL109 HEK-293T C393(0.99)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C393(1.22); C213(1.10)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C393(1.09); C229(0.69)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C229(0.90); C213(0.92); C54(1.11)  LDD1585  [6]
 LDCM0383  CL113 HEK-293T C393(1.11)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C393(1.02); C229(0.83)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C229(0.87); C213(0.92); C54(0.90)  LDD1589  [6]
 LDCM0387  CL117 HEK-293T C393(1.10)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C393(1.12); C229(1.07)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C229(0.85); C213(0.89); C54(0.87)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C393(1.13); C213(1.04)  LDD1594  [6]
 LDCM0392  CL121 HEK-293T C393(1.06)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C393(1.07); C229(0.89)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C229(1.00); C213(1.16); C54(0.96)  LDD1598  [6]
 LDCM0396  CL125 HEK-293T C393(1.04)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C393(1.00); C229(1.06)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C229(0.92); C213(1.14); C54(1.28)  LDD1602  [6]
 LDCM0400  CL13 HEK-293T C393(1.03)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C393(1.13); C229(0.99)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C229(0.94); C213(1.05); C54(1.19)  LDD1606  [6]
 LDCM0404  CL17 HEK-293T C229(0.93); C213(1.19)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C229(0.98); C213(1.04)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C213(1.09)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C393(1.18); C229(0.92)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C213(1.15)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C393(1.11); C229(0.99); C213(0.91)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C213(1.15)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C393(1.23); C213(1.12)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C393(1.13); C213(0.99)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C393(1.02)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C393(1.05); C229(0.78)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C229(0.66); C213(0.98); C54(1.07)  LDD1619  [6]
 LDCM0417  CL29 HEK-293T C229(0.64); C213(1.03)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C229(1.07); C213(1.04); C54(1.13)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C229(0.78); C213(0.86)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C213(1.10)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C213(1.03)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C393(1.03); C229(0.77); C213(1.09)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C213(0.95)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C393(1.32); C213(1.10)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C393(1.07); C213(1.24)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C393(1.03)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C229(0.73); C213(0.91); C54(1.73)  LDD1632  [6]
 LDCM0431  CL41 HEK-293T C229(0.89); C213(0.93)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C229(1.18); C213(0.96)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C213(0.89)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C213(1.00)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C393(1.06); C229(0.94); C213(0.78)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C213(0.91)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C393(1.17); C213(1.03)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C393(1.13); C213(0.99)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C393(1.10)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C229(0.93); C213(1.01)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C393(1.04); C229(0.80)  LDD1645  [6]
 LDCM0444  CL53 HEK-293T C229(0.69); C213(1.09)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C229(0.86); C213(1.31)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C213(1.18)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C213(1.06)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C393(1.21); C229(0.80); C213(0.95)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C213(0.99)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C393(1.25); C213(1.01)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C229(0.96); C213(1.06)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C393(1.07); C213(1.03)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C393(1.03)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C393(1.07); C229(1.05)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C229(0.80); C213(0.84); C54(0.86)  LDD1658  [6]
 LDCM0457  CL65 HEK-293T C229(0.81); C213(0.94)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C229(0.94); C213(0.98)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C213(1.09)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C213(1.29)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C393(1.12); C229(0.98); C213(0.84)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C213(1.11)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C213(1.01)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C393(1.25); C213(0.93)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C393(1.12); C213(1.06)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C393(1.05)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C393(1.04); C229(0.86)  LDD1670  [6]
 LDCM0470  CL77 HEK-293T C229(0.68); C213(0.97)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C229(1.04); C213(0.83)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C213(1.06)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C213(1.75)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C213(1.14)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C393(1.15); C229(0.79); C213(0.96)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C213(0.99)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C393(1.18); C213(1.13)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C393(1.16); C213(1.05)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C393(1.03)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C393(1.13); C229(0.87)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C229(0.91); C213(1.10); C54(0.95)  LDD1684  [6]
 LDCM0483  CL89 HEK-293T C229(0.76); C213(1.11)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C393(1.22); C229(1.01); C213(0.90)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C229(0.98); C213(1.34)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C213(1.05)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C213(1.05)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C393(1.01); C229(0.97); C213(1.02)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C213(0.91)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C393(1.11); C213(0.97)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C393(1.07); C213(1.17)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C393(1.01)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C393(1.08); C229(0.86)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C229(0.84); C213(0.92); C54(0.89)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C229(0.77); C213(0.95); C54(1.14)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C229(0.55); C213(0.93); C54(1.03)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C393(1.07); C229(0.82)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C393(1.11)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C393(1.00)  LDD1497  [6]
 LDCM0024  KB05 NB1 C393(1.80)  LDD3340  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 36 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arylacetamide deacetylase (AADAC) GDXG lipolytic enzyme family P22760
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) 3-beta-HSD family Q9H2F3
Adenosylhomocysteinase (AHCY) Adenosylhomocysteinase family P23526
GTP:AMP phosphotransferase AK3, mitochondrial (AK3) Adenylate kinase family Q9UIJ7
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (PYROXD2) Carotenoid/retinoid oxidoreductase family Q8N2H3
tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) RNA M5U methyltransferase family Q8IZ69
Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (PPIL6) Cyclophilin-type PPIase family Q8IXY8
ERO1-like protein alpha (ERO1A) EROs family Q96HE7
Epididymis-specific alpha-mannosidase (MAN2B2) Glycosyl hydrolase 38 family Q9Y2E5
Alpha-2,8-sialyltransferase 8E (ST8SIA5) Glycosyltransferase 29 family O15466
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (MGAT4B) Glycosyltransferase 54 family Q9UQ53
UDP-glucose:glycoprotein glucosyltransferase 2 (UGGT2) Glycosyltransferase 8 family Q9NYU1
Glutathione S-transferase P (GSTP1) Pi family P09211
Dihydropyrimidinase (DPYS) Hydantoinase/dihydropyrimidinase family Q14117
Dipeptidase 1 (DPEP1) Peptidase M19 family P16444
mRNA-capping enzyme (RNGTT) Non-receptor class of the protein-tyrosine phosphatase family; Eukaryotic GTase family O60942
Hepatocyte growth factor activator (HGFAC) Peptidase S1 family Q04756
Dolichol kinase (DOLK) Polyprenol kinase family Q9UPQ8
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) AGC Ser/Thr protein kinase family P22694
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Casein kinase I isoform gamma-2 (CSNK1G2) CK1 Ser/Thr protein kinase family P78368
Cyclin-dependent kinase 16 (CDK16) CMGC Ser/Thr protein kinase family Q00536
Homeodomain-interacting protein kinase 4 (HIPK4) CMGC Ser/Thr protein kinase family Q8NE63
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE) Ser/Thr protein kinase family Q14164
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) Short-chain dehydrogenases/reductases (SDR) family Q13268
Ras-related protein Rab-7b (RAB7B) Rab family Q96AH8
GTP-binding protein Rheb (RHEB) Rheb family Q15382
Kinesin-like protein KIF6 (KIF6) Kinesin family Q6ZMV9
Ubiquitin-conjugating enzyme E2 R2 (UBE2R2) Ubiquitin-conjugating enzyme family Q712K3
GATOR2 complex protein WDR24 (WDR24) WD repeat WDR24 family Q96S15
Dermcidin (DCD) . P81605
E3 ubiquitin-protein ligase RNF128 (RNF128) . Q8TEB7
E3 ubiquitin-protein ligase RNF34 (RNF34) . Q969K3
LON peptidase N-terminal domain and RING finger protein 3 (LONRF3) . Q496Y0
Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) . Q969V5
Patatin-like phospholipase domain-containing protein 5 (PNPLA5) . Q7Z6Z6
Transporter and channel
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Asc-type amino acid transporter 1 (SLC7A10) Amino acid-polyamine-organocation (APC) superfamily Q9NS82
Amyloid-beta precursor protein (APP) APP family P05067
Chloride channel protein 1 (CLCN1) Chloride channel family P35523
FXYD domain-containing ion transport regulator 7 (FXYD7) FXYD family P58549
Solute carrier family 22 member 6 (SLC22A6) Organic cation transporter (TC 2.A.1.19) family Q4U2R8
Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23) Mitochondrial carrier (TC 2.A.29) family Q9BV35
Sorting nexin-5 (SNX5) Sorting nexin family Q9Y5X3
Mucolipin-1 (MCOLN1) Transient receptor (TC 1.A.4) family Q9GZU1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) . O14745
Prosaposin (PSAP) . P07602
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear transcription factor Y subunit alpha (NFYA) NFYA/HAP2 subunit family P23511
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Ribosome quality control complex subunit TCF25 (TCF25) TCF25 family Q9BQ70
Zinc finger protein 747 (ZNF747) . Q9BV97
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 (WFIKKN1) WFIKKN family Q96NZ8
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chemokine-like protein TAFA-4 (TAFA4) TAFA family Q96LR4
Other
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-1 (ACTN1) Alpha-actinin family P12814
CST complex subunit CTC1 (CTC1) CTC1 family Q2NKJ3
Cyclin-L1 (CCNL1) Cyclin family Q9UK58
Cystatin-SA (CST2) Cystatin family P09228
DNA mismatch repair protein Msh2 (MSH2) DNA mismatch repair MutS family P43246
Armadillo repeat-containing X-linked protein 5 (ARMCX5) Eutherian X-chromosome-specific Armcx family Q6P1M9
Collagen alpha-1(XXIV) chain (COL24A1) Fibrillar collagen family Q17RW2
Heat shock 70 kDa protein 4 (HSPA4) Heat shock protein 70 family P34932
Integrin beta-5 (ITGB5) Integrin beta chain family P18084
LanC-like protein 2 (LANCL2) LanC-like protein family Q9NS86
Putative RNA-binding protein Luc7-like 2 (LUC7L2) Luc7 family Q9Y383
Nuclear transition protein 2 (TNP2) Nuclear transition protein 2 family Q05952
Ribosome biogenesis regulatory protein homolog (RRS1) RRS1 family Q15050
Selenoprotein V (SELENOV) SelWTH family P59797
Speedy protein E6 (SPDYE6) Speedy/Ringo family P0CI01
Synaptotagmin-11 (SYT11) Synaptotagmin family Q9BT88
Transcription initiation factor TFIID subunit 11 (TAF11) TAF11 family Q15544
Coronin-2B (CORO2B) WD repeat coronin family Q9UQ03
Actin nucleation-promoting factor WAS (WAS) . P42768
Ankyrin repeat domain-containing protein 10 (ANKRD10) . Q9NXR5
Bridging integrator 2 (BIN2) . Q9UBW5
Coiled-coil domain-containing protein 167 (CCDC167) . Q9P0B6
Follistatin-related protein 1 (FSTL1) . Q12841
Germinal center-associated signaling and motility protein (GCSAM) . Q8N6F7
Kelch-like protein 35 (KLHL35) . Q6PF15
Leucine zipper protein 4 (LUZP4) . Q9P127
Nuclear inhibitor of protein phosphatase 1 (PPP1R8) . Q12972
Protein AF-9 (MLLT3) . P42568
Synergin gamma (SYNRG) . Q9UMZ2
Transducin beta-like protein 3 (TBL3) . Q12788
Uncharacterized protein C1orf50 (C1orf50) . Q9BV19
Uncharacterized protein C6orf226 (C6orf226) . Q5I0X4
Zinc finger CCCH domain-containing protein 10 (ZC3H10) . Q96K80

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402