Details of the Target

General Information of Target

Target ID LDTP09682
Target Name RUN and FYVE domain-containing protein 2 (RUFY2)
Gene Name RUFY2
Gene ID 55680
Synonyms
KIAA1537; RABIP4R; RUN and FYVE domain-containing protein 2; Rab4-interacting protein related
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV
RKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMAD
YLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDF
SMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEE
LAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNE
ARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAI
NIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKY
LQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQI
ISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKD
KEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQR
CSSNLP
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q8WXA3
Ensemble ID
ENST00000388768.6
HGNC ID
HGNC:19761

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K498(10.00); K62(1.01); K99(9.12)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C595(2.25)  LDD3319  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
TPP-AC
 Probe Info  		N.A.  LDD0427  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C53(1.15)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C53(1.08)  LDD1508  [8]
 LDCM0237  AC12 HEK-293T C53(0.87)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C53(0.94)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C53(1.12)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C53(1.01)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C53(0.94)  LDD1516  [8]
 LDCM0279  AC2 HEK-293T C53(1.00)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C53(0.90)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C53(0.99)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C53(0.93)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C53(1.00)  LDD1522  [8]
 LDCM0285  AC25 HEK-293T C53(1.03)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C53(1.04)  LDD1525  [8]
 LDCM0288  AC28 HEK-293T C53(0.90)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C53(0.90)  LDD1528  [8]
 LDCM0291  AC30 HEK-293T C53(0.94)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C53(1.12)  LDD1531  [8]
 LDCM0294  AC33 HEK-293T C53(1.17)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C53(1.14)  LDD1534  [8]
 LDCM0297  AC36 HEK-293T C53(0.97)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C53(0.99)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C53(0.84)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C53(0.92)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C53(1.00)  LDD1540  [8]
 LDCM0303  AC41 HEK-293T C53(1.14)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C53(1.13)  LDD1543  [8]
 LDCM0306  AC44 HEK-293T C53(0.94)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C53(0.98)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C53(0.88)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C53(1.01)  LDD1548  [8]
 LDCM0311  AC49 HEK-293T C53(1.06)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C53(0.94)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C53(1.08)  LDD1552  [8]
 LDCM0315  AC52 HEK-293T C53(0.94)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C53(1.15)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C53(1.03)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C53(1.02)  LDD1557  [8]
 LDCM0320  AC57 HEK-293T C53(0.99)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C53(0.95)  LDD1560  [8]
 LDCM0323  AC6 HEK-293T C53(0.85)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C53(0.91)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C53(1.12)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C53(0.99)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C53(1.04)  LDD1566  [8]
 LDCM0334  AC7 HEK-293T C53(1.05)  LDD1568  [8]
 LDCM0248  AKOS034007472 HEK-293T C53(0.89)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C53(1.07)  LDD1570  [8]
 LDCM0367  CL1 HEK-293T C53(0.83)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C53(0.57)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C53(1.25)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C53(0.89)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C53(0.94)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C53(1.19); C546(0.88)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C53(0.97)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C53(1.05)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C53(0.87)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C53(1.16); C546(1.12)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C53(1.01)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C53(0.97)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C53(0.77)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C53(0.66)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C53(1.12); C546(0.93)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C53(0.96)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C53(0.95)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C53(0.95)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C53(1.03); C546(0.96)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C53(1.20)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C53(1.14)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C53(1.14)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C53(1.31); C546(0.95)  LDD1593  [8]
 LDCM0391  CL120 HEK-293T C53(1.06)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C53(0.93)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C53(0.85)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C53(1.01); C546(1.22)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C53(1.12)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C53(1.02)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C53(1.06)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C53(1.31); C546(1.47)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C53(1.15)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C53(0.86)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C53(1.06)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C53(1.14); C546(0.96)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C53(1.02)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C53(0.93)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C53(0.90)  LDD1609  [8]
 LDCM0407  CL2 HEK-293T C53(0.87)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C53(0.80)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C53(0.75)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C53(0.71)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C53(0.81)  LDD1615  [8]
 LDCM0413  CL25 HEK-293T C53(0.95)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C53(0.94)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C53(1.05); C546(0.96)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C53(0.93)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C53(0.93)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C53(0.99); C546(1.01)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C53(0.88)  LDD1623  [8]
 LDCM0421  CL32 HEK-293T C53(0.62)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C53(0.70)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C53(0.73)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C53(0.66)  LDD1628  [8]
 LDCM0426  CL37 HEK-293T C53(0.99)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C53(0.80); C546(0.92)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C53(1.01)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C53(0.96)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C53(0.83)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C53(0.91)  LDD1636  [8]
 LDCM0434  CL44 HEK-293T C53(0.66)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C53(0.81)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C53(0.58)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C53(0.83)  LDD1641  [8]
 LDCM0439  CL49 HEK-293T C53(1.11)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C53(1.07)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C53(1.10)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C53(1.00)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C53(0.76)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C53(0.83)  LDD1648  [8]
 LDCM0447  CL56 HEK-293T C53(0.73)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C53(0.79)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C53(0.66)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C53(0.76)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C53(0.88)  LDD1654  [8]
 LDCM0453  CL61 HEK-293T C53(0.94)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C53(1.18)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C53(1.17); C546(1.05)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C53(0.68)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C53(1.05)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C53(0.93)  LDD1661  [8]
 LDCM0460  CL68 HEK-293T C53(0.79)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C53(0.87)  LDD1664  [8]
 LDCM0463  CL70 HEK-293T C53(0.59)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C53(0.94)  LDD1667  [8]
 LDCM0466  CL73 HEK-293T C53(1.07)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C53(0.95)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C53(0.99)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C53(0.97)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C53(0.92)  LDD1674  [8]
 LDCM0473  CL8 HEK-293T C53(0.81)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C53(0.74)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C53(1.03)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C53(0.68)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C53(0.97)  LDD1680  [8]
 LDCM0479  CL85 HEK-293T C53(0.99)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C53(1.07)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C53(1.28); C546(1.61)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C53(1.18)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C53(1.16)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C53(0.95)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C53(0.84)  LDD1688  [8]
 LDCM0487  CL92 HEK-293T C53(0.73)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C53(0.84)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C53(0.67)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C53(0.78)  LDD1693  [8]
 LDCM0492  CL97 HEK-293T C53(1.01)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C53(0.98)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C53(1.13); C546(1.14)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C53(1.04); C546(1.03)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C53(1.33); C546(1.27)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C53(0.93)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C53(1.07)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C53(0.99)  LDD1497  [8]
 LDCM0024  KB05 MEWO C595(2.25)  LDD3319  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-33A (RAB33A) Rab family Q14088
Ras-related protein Rab-33B (RAB33B) Rab family Q9H082

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402