Details of the Target

General Information of Target

Target ID LDTP09675
Target Name Ectodysplasin-A receptor-associated adapter protein (EDARADD)
Gene Name EDARADD
Gene ID 128178
Synonyms
Ectodysplasin-A receptor-associated adapter protein; EDAR-associated death domain protein; Protein crinkled homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLRTTKQMGRGTKAPGHQEDHMVKEPVEDTDPSTLSFNMSDKYPIQDTELPKAEECDTI
TLNCPRNSDMKNQGEENGFPDSTGDPLPEISKDNSCKENCTCSSCLLRAPTISDLLNDQD
LLDVIRIKLDPCHPTVKNWRNFASKWGMSYDELCFLEQRPQSPTLEFLLRNSQRTVGQLM
ELCRLYHRADVEKVLRRWVDEEWPKRERGDPSRHF
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.
Uniprot ID
Q8WWZ3
Ensemble ID
ENST00000334232.9
HGNC ID
HGNC:14341

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC15 SNV: p.G2C .
HCT116 Deletion: p.D42NfsTer20 .
NCIH358 SNV: p.R4W .
TE4 SNV: p.W203L .
WM115 SNV: p.R170W .
WM2664 SNV: p.R170W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C57(3.62); C64(3.62)  LDD0080  [1]
IPM
 Probe Info  		N.A.  LDD0005  [2]
VSF
 Probe Info  		N.A.  LDD0007  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C154(1.06)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C132(1.23)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C132(1.22)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C132(1.37)  LDD1513  [4]
 LDCM0278  AC19 HEK-293T C154(0.99)  LDD1517  [4]
 LDCM0280  AC20 HEK-293T C132(1.45)  LDD1519  [4]
 LDCM0282  AC22 HEK-293T C132(1.52)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C132(1.58)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C154(1.41)  LDD1523  [4]
 LDCM0287  AC27 HEK-293T C154(1.05)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C132(1.12)  LDD1527  [4]
 LDCM0290  AC3 HEK-293T C154(0.95)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C132(0.93)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C132(1.00)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C154(1.37)  LDD1532  [4]
 LDCM0296  AC35 HEK-293T C154(1.09)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C132(1.46)  LDD1536  [4]
 LDCM0299  AC38 HEK-293T C132(1.35)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C132(1.65)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C132(0.88)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C154(1.07)  LDD1541  [4]
 LDCM0305  AC43 HEK-293T C154(1.39)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C132(1.44)  LDD1545  [4]
 LDCM0308  AC46 HEK-293T C132(1.32)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C132(1.34)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C154(1.59)  LDD1549  [4]
 LDCM0314  AC51 HEK-293T C154(1.34)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C132(1.33)  LDD1554  [4]
 LDCM0317  AC54 HEK-293T C132(1.51)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C132(1.72)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C154(1.23)  LDD1558  [4]
 LDCM0322  AC59 HEK-293T C154(1.18)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C132(0.85)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C132(1.30)  LDD1563  [4]
 LDCM0326  AC62 HEK-293T C132(1.28)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C132(1.37)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C154(1.16)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C132(0.82)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C154(0.83)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C154(1.26)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C132(1.02)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C132(0.90)  LDD1572  [4]
 LDCM0370  CL101 HEK-293T C132(1.13)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C132(0.95)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C132(1.25)  LDD1576  [4]
 LDCM0374  CL105 HEK-293T C132(1.26)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C132(1.15)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C132(1.38)  LDD1580  [4]
 LDCM0378  CL109 HEK-293T C132(1.03)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C132(1.47)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C132(1.00)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C132(1.03)  LDD1585  [4]
 LDCM0383  CL113 HEK-293T C132(1.35)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C132(1.09)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C132(1.10)  LDD1589  [4]
 LDCM0387  CL117 HEK-293T C132(1.34)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C132(1.18)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C132(0.99)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C154(1.31)  LDD1594  [4]
 LDCM0392  CL121 HEK-293T C132(1.26)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C132(1.07)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C132(1.14)  LDD1598  [4]
 LDCM0396  CL125 HEK-293T C132(0.95)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C132(1.16)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C132(1.02)  LDD1602  [4]
 LDCM0400  CL13 HEK-293T C132(0.97)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C132(1.11)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C132(0.92)  LDD1606  [4]
 LDCM0406  CL19 HEK-293T C154(1.31)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C132(1.11)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C132(1.32)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C132(1.33)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C132(1.98)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C154(1.00)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C132(1.25)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C132(1.32)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C132(1.16)  LDD1619  [4]
 LDCM0418  CL3 HEK-293T C132(0.90)  LDD1622  [4]
 LDCM0420  CL31 HEK-293T C154(0.91)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C132(1.35)  LDD1625  [4]
 LDCM0423  CL34 HEK-293T C132(1.61)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C132(2.04)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C154(0.99)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C132(1.31)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C132(1.36)  LDD1632  [4]
 LDCM0433  CL43 HEK-293T C154(0.71)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C132(1.36)  LDD1638  [4]
 LDCM0436  CL46 HEK-293T C132(1.61)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C132(1.84)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C154(0.96)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C132(1.01)  LDD1643  [4]
 LDCM0441  CL50 HEK-293T C132(1.20)  LDD1645  [4]
 LDCM0446  CL55 HEK-293T C154(1.14)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C132(1.47)  LDD1650  [4]
 LDCM0449  CL58 HEK-293T C132(1.59)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C132(1.80)  LDD1653  [4]
 LDCM0452  CL60 HEK-293T C154(1.37)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C132(1.27)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C132(1.23)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C132(1.25)  LDD1658  [4]
 LDCM0459  CL67 HEK-293T C154(1.00)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C132(1.35)  LDD1663  [4]
 LDCM0462  CL7 HEK-293T C154(1.06)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C132(1.58)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C132(1.69)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C154(1.31)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C132(0.89)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C132(1.17)  LDD1670  [4]
 LDCM0472  CL79 HEK-293T C154(1.09)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C132(0.73)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C132(0.85)  LDD1677  [4]
 LDCM0476  CL82 HEK-293T C132(1.04)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C132(1.29)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C154(0.75)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C132(1.25)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C132(1.14)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C132(1.07)  LDD1684  [4]
 LDCM0486  CL91 HEK-293T C154(1.33)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C132(1.33)  LDD1690  [4]
 LDCM0489  CL94 HEK-293T C132(1.55)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C132(1.37)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C154(0.86)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C132(0.98)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C132(0.96)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C132(0.90)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C132(1.38)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C132(0.89)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C132(1.13)  LDD1631  [4]
 LDCM0022  KB02 HCT 116 C57(3.62); C64(3.62)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C57(1.74); C64(1.74)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C57(2.05); C64(2.05)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Arkadia (RNF111) Arkadia family Q6ZNA4
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
E3 ubiquitin-protein ligase SHPRH (SHPRH) SNF2/RAD54 helicase family Q149N8
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme family P63279
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Small ubiquitin-related modifier 5 (SUMO1P1) Ubiquitin family G2XKQ0

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402