Details of the Target

General Information of Target

Target ID LDTP09592
Target Name Vesicle transport protein SFT2A (SFT2D1)
Gene Name SFT2D1
Gene ID 113402
Synonyms
C6orf83; Vesicle transport protein SFT2A; SFT2 domain-containing protein 1; pRGR1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEKLRRVLSGQDDEEQGLTAQVLDASSLSFNTRLKWFAICFVCGVFFSILGTGLLWLPGG
IKLFAVFYTLGNLAALASTCFLMGPVKQLKKMFEATRLLATIVMLLCFIFTLCAALWWHK
KGLAVLFCILQFLSMTWYSLSYIPYARDAVIKCCSSLLS
Target Bioclass
Other
Family
SFT2 family
Subcellular location
Membrane
Function May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
Uniprot ID
Q8WV19
Ensemble ID
ENST00000361731.4
HGNC ID
HGNC:21102

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		1.14  LDD2182  [1]
DBIA
 Probe Info  		C153(1.06)  LDD0547  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 HCT 116 C153(1.06)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C153(1.03)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C153(1.20)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C153(1.25)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C153(1.17)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C153(1.05)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C153(1.24)  LDD0553  [2]
 LDCM0238  AC120 HCT 116 C153(0.94)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C153(0.82)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C153(0.87)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C153(0.69)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C153(0.96)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C153(0.93)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C153(0.98)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C153(0.93)  LDD0562  [2]
 LDCM0285  AC25 HCT 116 C153(0.94)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C153(1.15)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C153(1.05)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C153(1.33)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C153(1.40)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C153(1.30)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C153(1.19)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C153(1.47)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C153(1.15)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C153(0.93)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C153(0.87)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C153(0.98)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C153(0.90)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C153(0.95)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C153(0.94)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C153(0.95)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C153(0.94)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C153(0.99)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C153(0.93)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C153(0.84)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C153(0.82)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C153(0.83)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C153(0.88)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C153(0.85)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C153(0.94)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C153(1.02)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C153(0.92)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C153(0.84)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C153(0.78)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C153(0.80)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C153(0.94)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C153(0.91)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C153(1.12)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C153(1.12)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C153(1.19)  LDD0639  [2]
 LDCM0324  AC60 HCT 116 C153(1.21)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C153(1.17)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C153(1.20)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C153(0.98)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C153(1.15)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C153(1.10)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C153(1.00)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C153(1.20)  LDD0648  [2]
 LDCM0349  AC83 HCT 116 C153(1.09)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C153(1.14)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C153(1.12)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C153(1.15)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C153(1.25)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C153(1.11)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C153(1.18)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C153(1.18)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C153(1.04)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C153(1.08)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C153(1.16)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C153(1.02)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C153(1.22)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C153(1.11)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C153(1.23)  LDD0681  [2]
 LDCM0382  CL112 HCT 116 C153(0.92)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C153(1.10)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C153(1.24)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C153(1.17)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C153(0.99)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C153(0.94)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C153(0.93)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C153(1.04)  LDD0706  [2]
 LDCM0391  CL120 HCT 116 C153(0.92)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C153(1.12)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C153(0.91)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C153(0.69)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C153(0.79)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C153(1.16)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C153(1.12)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C153(1.33)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C153(1.10)  LDD0716  [2]
 LDCM0453  CL61 HCT 116 C153(0.92)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C153(0.87)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C153(0.88)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C153(0.93)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C153(0.83)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C153(0.82)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C153(0.69)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C153(0.57)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C153(0.81)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C153(0.81)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C153(0.73)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C153(0.84)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C153(0.76)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C153(0.68)  LDD0784  [2]
 LDCM0625  F8 Ramos 0.90  LDD2187  [1]
 LDCM0572  Fragment10 Ramos 1.18  LDD2189  [1]
 LDCM0573  Fragment11 Ramos 0.05  LDD2190  [1]
 LDCM0574  Fragment12 Ramos 1.02  LDD2191  [1]
 LDCM0575  Fragment13 Ramos 1.23  LDD2192  [1]
 LDCM0576  Fragment14 Ramos 7.10  LDD2193  [1]
 LDCM0579  Fragment20 Ramos 3.56  LDD2194  [1]
 LDCM0580  Fragment21 Ramos 0.57  LDD2195  [1]
 LDCM0582  Fragment23 Ramos 2.61  LDD2196  [1]
 LDCM0578  Fragment27 Ramos 1.19  LDD2197  [1]
 LDCM0586  Fragment28 Ramos 1.01  LDD2198  [1]
 LDCM0588  Fragment30 Ramos 1.02  LDD2199  [1]
 LDCM0589  Fragment31 Ramos 1.33  LDD2200  [1]
 LDCM0590  Fragment32 Ramos 0.84  LDD2201  [1]
 LDCM0468  Fragment33 HCT 116 C153(1.01)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos 0.78  LDD2203  [1]
 LDCM0566  Fragment4 Ramos 0.78  LDD2184  [1]
 LDCM0610  Fragment52 Ramos 1.41  LDD2204  [1]
 LDCM0614  Fragment56 Ramos 1.85  LDD2205  [1]
 LDCM0569  Fragment7 Ramos 0.86  LDD2186  [1]
 LDCM0571  Fragment9 Ramos 2.99  LDD2188  [1]
 LDCM0022  KB02 Ramos 1.14  LDD2182  [1]
 LDCM0024  KB05 Ramos 3.52  LDD2185  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Threonine--tRNA ligase, mitochondrial (TARS2) Class-II aminoacyl-tRNA synthetase family Q9BW92
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
FAST kinase domain-containing protein 4 (TBRG4) FAST kinase family Q969Z0
Inactive glycosyltransferase 25 family member 3 (CERCAM) Glycosyltransferase 25 family Q5T4B2
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Ubiquitin thioesterase otulin (OTULIN) Peptidase C65 family Q96BN8
Hepatocyte growth factor-like protein (MST1) Peptidase S1 family P26927
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Derlin-2 (DERL2) Derlin family Q9GZP9
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 255B (TMEM255B) TMEM255 family Q8WV15
Syntenin-1 (SDCBP) . O00560
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Synaptotagmin-16 (SYT16) Synaptotagmin family Q17RD7
Arfaptin-1 (ARFIP1) . P53367
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7
SCAN domain-containing protein 1 (SCAND1) . P57086

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.