Details of the Target

General Information of Target

Target ID LDTP09561
Target Name Phospholipase ABHD3 (ABHD3)
Gene Name ABHD3
Gene ID 171586
Synonyms
Phospholipase ABHD3; EC 3.1.1.32; EC 3.1.1.4; Abhydrolase domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRLAMDLRMLSRELSLYLEHQVRVGFFGSGVGLSLILGFSVAYAFYYLSSIAKKPQLVT
GGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQI
SLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVA
GENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLM
AAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKS
IREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAK
QNPNVALVLTSYGGHIGFLEGIWPRQSTYMDRVFKQFVQAMVEHGHELS
Target Bioclass
Enzyme
Family
AB hydrolase superfamily, AB hydrolase 4 family
Subcellular location
Membrane
Function
Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.
Uniprot ID
Q8WU67
Ensemble ID
ENST00000289119.7
HGNC ID
HGNC:18718

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCSW1 SNV: p.N342H .
HCT15 SNV: p.A243V .
IM95 SNV: p.T131A .
SHP77 Deletion: p.K102NfsTer59 .
SUPT1 SNV: p.A136V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C340(1.00)  LDD2182  [1]
DBIA
 Probe Info  		C73(0.45); C86(0.45)  LDD1093  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [3]
AOyne
 Probe Info  		14.50  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OEA-DA
 Probe Info  		20.00  LDD0046  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C73(0.45); C86(0.45)  LDD1093  [2]
 LDCM0230  AC113 PaTu 8988t C73(0.92); C86(0.92)  LDD1109  [2]
 LDCM0231  AC114 PaTu 8988t C73(1.25); C86(1.25)  LDD1110  [2]
 LDCM0232  AC115 PaTu 8988t C73(1.24); C86(1.24)  LDD1111  [2]
 LDCM0233  AC116 PaTu 8988t C73(0.79); C86(0.79)  LDD1112  [2]
 LDCM0234  AC117 PaTu 8988t C73(0.80); C86(0.80)  LDD1113  [2]
 LDCM0235  AC118 PaTu 8988t C73(0.82); C86(0.82)  LDD1114  [2]
 LDCM0236  AC119 PaTu 8988t C73(0.69); C86(0.69)  LDD1115  [2]
 LDCM0238  AC120 PaTu 8988t C73(1.04); C86(1.04)  LDD1117  [2]
 LDCM0239  AC121 PaTu 8988t C73(0.77); C86(0.77)  LDD1118  [2]
 LDCM0240  AC122 PaTu 8988t C73(2.37); C86(2.37)  LDD1119  [2]
 LDCM0241  AC123 PaTu 8988t C73(0.96); C86(0.96)  LDD1120  [2]
 LDCM0242  AC124 PaTu 8988t C73(0.93); C86(0.93)  LDD1121  [2]
 LDCM0243  AC125 PaTu 8988t C73(1.11); C86(1.11)  LDD1122  [2]
 LDCM0244  AC126 PaTu 8988t C73(0.90); C86(0.90)  LDD1123  [2]
 LDCM0245  AC127 PaTu 8988t C73(0.68); C86(0.68)  LDD1124  [2]
 LDCM0246  AC128 PaTu 8988t C73(0.77); C86(0.77)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C73(0.96); C86(0.96)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C73(1.14); C86(1.14)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C73(1.12); C86(1.12)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C73(1.58); C86(1.58)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C73(0.89); C86(0.89)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C73(0.94); C86(0.94)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C73(0.80); C86(0.80)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C73(0.76); C86(0.76)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C73(0.90); C86(0.90)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C73(1.14); C86(1.14)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C73(1.05); C86(1.05)  LDD1137  [2]
 LDCM0260  AC140 PaTu 8988t C73(1.00); C86(1.00)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C73(0.87); C86(0.87)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C73(1.12); C86(1.12)  LDD1141  [2]
 LDCM0276  AC17 PaTu 8988t C73(1.24); C86(1.24)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C73(0.70); C86(0.70)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C73(0.83); C86(0.83)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C73(0.52); C86(0.52)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C73(0.77); C86(0.77)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C73(0.79); C86(0.79)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C73(0.64); C86(0.64)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C73(0.75); C86(0.75)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C73(1.20); C86(1.20)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C73(0.93); C86(0.93)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C73(1.06); C86(1.06)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C73(0.82); C86(0.82)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C73(0.97); C86(0.97)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C73(1.01); C86(1.01)  LDD1168  [2]
 LDCM0290  AC3 PaTu 8988t C73(0.39); C86(0.39)  LDD1169  [2]
 LDCM0291  AC30 PaTu 8988t C73(1.08); C86(1.08)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C73(1.57); C86(1.57)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C73(0.84); C86(0.84)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C73(0.95); C86(0.95)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C73(0.75); C86(0.75)  LDD1174  [2]
 LDCM0301  AC4 PaTu 8988t C73(0.43); C86(0.43)  LDD1180  [2]
 LDCM0308  AC46 PaTu 8988t C73(1.61); C86(1.61)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C73(1.41); C86(1.41)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C73(1.52); C86(1.52)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C73(1.31); C86(1.31)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C73(0.68); C86(0.68)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C73(1.07); C86(1.07)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C73(0.52); C86(0.52)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C73(0.75); C86(0.75)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C73(1.32); C86(1.32)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C73(1.19); C86(1.19)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C73(1.23); C86(1.23)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C73(1.98); C86(1.98)  LDD1198  [2]
 LDCM0367  CL1 PaTu 8988t C73(0.81); C86(0.81)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C73(0.65); C86(0.65)  LDD1247  [2]
 LDCM0369  CL100 PaTu 8988t C73(0.52); C86(0.52)  LDD1248  [2]
 LDCM0374  CL105 PaTu 8988t C73(1.59); C86(1.59)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C73(1.17); C86(1.17)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C73(0.98); C86(0.98)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C73(1.15); C86(1.15)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C73(1.02); C86(1.02)  LDD1257  [2]
 LDCM0379  CL11 PaTu 8988t C73(1.65); C86(1.65)  LDD1258  [2]
 LDCM0380  CL110 PaTu 8988t C73(0.82); C86(0.82)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C73(0.68); C86(0.68)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C73(1.16); C86(1.16)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C73(1.04); C86(1.04)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C73(1.15); C86(1.15)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C73(0.86); C86(0.86)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C73(1.49); C86(1.49)  LDD1265  [2]
 LDCM0390  CL12 PaTu 8988t C73(0.80); C86(0.80)  LDD1269  [2]
 LDCM0392  CL121 PaTu 8988t C73(1.48); C86(1.48)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C73(0.81); C86(0.81)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C73(1.16); C86(1.16)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C73(1.52); C86(1.52)  LDD1274  [2]
 LDCM0400  CL13 PaTu 8988t C73(0.65); C86(0.65)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C73(0.57); C86(0.57)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C73(0.90); C86(0.90)  LDD1281  [2]
 LDCM0407  CL2 PaTu 8988t C73(1.13); C86(1.13)  LDD1286  [2]
 LDCM0418  CL3 PaTu 8988t C73(0.83); C86(0.83)  LDD1297  [2]
 LDCM0420  CL31 PaTu 8988t C73(1.03); C86(1.03)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C73(0.93); C86(0.93)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C73(1.79); C86(1.79)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C73(0.86); C86(0.86)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C73(0.80); C86(0.80)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C73(1.24); C86(1.24)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C73(0.64); C86(0.64)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C73(1.08); C86(1.08)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C73(1.11); C86(1.11)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C73(0.86); C86(0.86)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C73(0.99); C86(0.99)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C73(0.95); C86(0.95)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C73(0.84); C86(0.84)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C73(0.95); C86(0.95)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C73(0.96); C86(0.96)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C73(1.09); C86(1.09)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C73(0.92); C86(0.92)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C73(1.25); C86(1.25)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C73(2.04); C86(2.04)  LDD1318  [2]
 LDCM0440  CL5 PaTu 8988t C73(0.76); C86(0.76)  LDD1319  [2]
 LDCM0441  CL50 PaTu 8988t C73(1.21); C86(1.21)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C73(1.42); C86(1.42)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C73(1.14); C86(1.14)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C73(1.35); C86(1.35)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C73(2.39); C86(2.39)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C73(0.89); C86(0.89)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C73(0.42); C86(0.42)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C73(1.45); C86(1.45)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C73(1.42); C86(1.42)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C73(0.94); C86(0.94)  LDD1329  [2]
 LDCM0451  CL6 PaTu 8988t C73(0.59); C86(0.59)  LDD1330  [2]
 LDCM0452  CL60 PaTu 8988t C73(0.74); C86(0.74)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C73(0.86); C86(0.86)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C73(0.99); C86(0.99)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C73(0.93); C86(0.93)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C73(0.84); C86(0.84)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C73(0.73); C86(0.73)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C73(0.76); C86(0.76)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C73(0.61); C86(0.61)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C73(0.66); C86(0.66)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C73(0.58); C86(0.58)  LDD1340  [2]
 LDCM0462  CL7 PaTu 8988t C73(0.72); C86(0.72)  LDD1341  [2]
 LDCM0463  CL70 PaTu 8988t C73(0.47); C86(0.47)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C73(0.78); C86(0.78)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C73(0.72); C86(0.72)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C73(0.71); C86(0.71)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C73(0.99); C86(0.99)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C73(1.01); C86(1.01)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C73(0.97); C86(0.97)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C73(0.84); C86(0.84)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C73(0.86); C86(0.86)  LDD1351  [2]
 LDCM0473  CL8 PaTu 8988t C73(1.05); C86(1.05)  LDD1352  [2]
 LDCM0474  CL80 PaTu 8988t C73(0.87); C86(0.87)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C73(0.94); C86(0.94)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C73(1.46); C86(1.46)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C73(1.23); C86(1.23)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C73(0.92); C86(0.92)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C73(1.02); C86(1.02)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C73(1.23); C86(1.23)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C73(1.04); C86(1.04)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C73(0.89); C86(0.89)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C73(0.67); C86(0.67)  LDD1362  [2]
 LDCM0484  CL9 PaTu 8988t C73(0.64); C86(0.64)  LDD1363  [2]
 LDCM0485  CL90 PaTu 8988t C73(1.30); C86(1.30)  LDD1364  [2]
 LDCM0486  CL91 PaTu 8988t C73(0.51); C86(0.51)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C73(0.65); C86(0.65)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C73(0.48); C86(0.48)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C73(0.59); C86(0.59)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C73(0.58); C86(0.58)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C73(0.55); C86(0.55)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C73(0.60); C86(0.60)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C73(0.58); C86(0.58)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C73(0.48); C86(0.48)  LDD1373  [2]
 LDCM0625  F8 Ramos C340(0.75)  LDD2187  [1]
 LDCM0572  Fragment10 Ramos C340(1.19)  LDD2189  [1]
 LDCM0573  Fragment11 Ramos C340(1.64)  LDD2190  [1]
 LDCM0574  Fragment12 Ramos C340(1.88)  LDD2191  [1]
 LDCM0575  Fragment13 Ramos C340(0.79)  LDD2192  [1]
 LDCM0576  Fragment14 Ramos C340(1.05)  LDD2193  [1]
 LDCM0580  Fragment21 Ramos C340(0.76)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C340(0.88)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C340(0.79)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C340(0.97)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C340(0.84)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C340(0.91)  LDD2200  [1]
 LDCM0590  Fragment32 Ramos C340(1.37)  LDD2201  [1]
 LDCM0468  Fragment33 PaTu 8988t C73(0.68); C86(0.68)  LDD1347  [2]
 LDCM0596  Fragment38 Ramos C340(0.79)  LDD2203  [1]
 LDCM0566  Fragment4 Ramos C340(0.69)  LDD2184  [1]
 LDCM0427  Fragment51 PaTu 8988t C73(0.91); C86(0.91)  LDD1306  [2]
 LDCM0610  Fragment52 Ramos C340(1.23)  LDD2204  [1]
 LDCM0614  Fragment56 Ramos C340(0.64)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C340(2.80)  LDD2186  [1]
 LDCM0571  Fragment9 Ramos C340(1.99)  LDD2188  [1]
 LDCM0022  KB02 Ramos C340(1.00)  LDD2182  [1]
 LDCM0023  KB03 Ramos C340(2.25)  LDD2183  [1]
 LDCM0024  KB05 Ramos C340(2.59)  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570