Details of the Target

General Information of Target

Target ID LDTP09361
Target Name Zinc finger protein 564 (ZNF564)
Gene Name ZNF564
Gene ID 163050
Synonyms
Zinc finger protein 564
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSVASEDVAVNFTLEEWALLDPSQKKLYRDVMRETFRNLACVGKKWEDQSIEDWYKNQG
RILRNHMEEGLSESKEYDQCGEAFSQILNLNLNKKIPTIVRPCECSLCGKVFMHHSSLSR
HIRSHLGHKPYDYQEYGEKPYKCKQCGKAFSSCQSFRRHERTHTGEKPYACPECGKAFIS
LPSVRRHMIKHTGDGPYKCQECGKAFDRPSLFQIHERTHTGEKPYECQECAKAFISLPSF
QRHMIRHTGDGPYKCQECGKAFDRPSLFRIHERTHTGEKPHECKQCGKAFISFTNFQSHM
IRHTGDGPYKCKVCGRAFIFPSYVRKHERTHTGEKPYECNKCGKTFSSSSNVRTHERTHT
GEKPYECKECGKAFISLPSVRRHMIKHTGDGPYKCQVCGRAFDCPSSFQIHERTHTGEKP
YECQVCGKAFISLKRIRKHMILHTGDGPYKCQVCGKAFDCPSSVRTHERTHTGEKPYECK
ECGKAFNYASSIRIHERTHTGEKPYECKQCGKTFSYSSSFQRHERAHNGDKPYVKNVGKL
SFITQPSNTCENE
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8TBZ8
Ensemble ID
ENST00000339282.12
HGNC ID
HGNC:31106

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C367(2.31)  LDD0170  [1]
DBIA
 Probe Info  		C460(22.64)  LDD0209  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C367(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C367(2.25)  LDD0171  [1]
 LDCM0215  AC10 HEK-293T C153(1.06)  LDD0813  [4]
 LDCM0226  AC11 HEK-293T C153(1.07)  LDD0824  [4]
 LDCM0237  AC12 HEK-293T C153(1.16)  LDD0835  [4]
 LDCM0259  AC14 HEK-293T C153(1.04)  LDD0857  [4]
 LDCM0263  AC143 HEK-293T C153(1.28)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C153(0.92)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C153(0.96)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C153(1.06)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C153(1.05)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C153(1.04)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C153(1.07)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C153(1.07)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C153(1.03)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C153(1.00)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C153(1.05)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C153(0.98)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C153(1.10)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C153(1.10)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C153(0.91)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C153(0.86)  LDD2165  [4]
 LDCM0281  AC21 HEK-293T C460(1.03)  LDD1520  [5]
 LDCM0289  AC29 HEK-293T C460(0.98)  LDD1528  [5]
 LDCM0298  AC37 HEK-293T C460(0.93)  LDD1537  [5]
 LDCM0307  AC45 HEK-293T C460(1.02)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C153(0.90)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C153(1.07)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C153(1.03)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C153(1.18)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C460(0.81)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C153(1.08)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C153(0.98)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C153(0.93)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C153(0.96)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C153(1.02)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C153(1.09)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C153(1.10)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C153(0.84)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C153(0.96)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C153(0.84)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C153(0.88)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C153(0.78)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C153(0.94)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C153(0.80)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C153(0.79)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C153(0.89)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C153(0.90)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C153(0.90)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C153(0.83)  LDD0929  [4]
 LDCM0334  AC7 HEK-293T C153(1.08)  LDD0932  [4]
 LDCM0345  AC8 HEK-293T C153(0.90)  LDD0943  [4]
 LDCM0248  AKOS034007472 HEK-293T C153(0.90)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C153(0.98)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C153(0.97)  LDD0873  [4]
 LDCM0367  CL1 HEK-293T C460(1.09)  LDD1571  [5]
 LDCM0370  CL101 HEK-293T C153(0.91)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C153(0.95)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C153(0.96)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C153(0.96)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C460(1.19)  LDD1578  [5]
 LDCM0378  CL109 HEK-293T C460(1.02)  LDD1582  [5]
 LDCM0383  CL113 HEK-293T C460(1.02)  LDD1587  [5]
 LDCM0387  CL117 HEK-293T C460(1.03)  LDD1591  [5]
 LDCM0392  CL121 HEK-293T C153(0.93)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C153(0.96)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C153(0.97)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C153(0.97)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C153(0.83)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C153(0.90)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C153(0.95)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C153(0.87)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C460(0.99)  LDD1604  [5]
 LDCM0409  CL21 HEK-293T C460(0.94)  LDD1613  [5]
 LDCM0413  CL25 HEK-293T C460(0.91)  LDD1617  [5]
 LDCM0420  CL31 HEK-293T C153(1.01)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C153(0.68)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C153(1.45)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C153(0.90)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C153(0.90)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C153(1.01)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C153(0.76)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C153(1.85)  LDD1026  [4]
 LDCM0430  CL40 HEK-293T C153(1.27)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C153(1.48)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C153(1.45)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C153(2.23)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C153(1.42)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C153(1.18)  LDD1033  [4]
 LDCM0439  CL49 HEK-293T C460(0.89)  LDD1643  [5]
 LDCM0448  CL57 HEK-293T C460(0.93)  LDD1651  [5]
 LDCM0453  CL61 HEK-293T C460(1.01)  LDD1656  [5]
 LDCM0461  CL69 HEK-293T C460(1.00)  LDD1664  [5]
 LDCM0466  CL73 HEK-293T C460(0.98)  LDD1669  [5]
 LDCM0475  CL81 HEK-293T C460(0.96)  LDD1678  [5]
 LDCM0479  CL85 HEK-293T C460(0.92)  LDD1682  [5]
 LDCM0484  CL9 HEK-293T C460(0.96)  LDD1687  [5]
 LDCM0488  CL93 HEK-293T C460(0.85)  LDD1691  [5]
 LDCM0492  CL97 HEK-293T C460(1.06)  LDD1695  [5]
 LDCM0427  Fragment51 HEK-293T C153(0.88)  LDD1025  [4]
 LDCM0022  KB02 A101D C460(4.04)  LDD2250  [6]
 LDCM0023  KB03 Jurkat C460(22.64)  LDD0209  [2]
 LDCM0024  KB05 Hs 936.T C460(1.84)  LDD3313  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) Class-II pyridoxal-phosphate-dependent aminotransferase family P13196
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7) Complex I NDUFB7 subunit family P17568
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) . Q9HD26
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein PLAGL2 (PLAGL2) Krueppel C2H2-type zinc-finger protein family Q9UPG8
Homeobox protein MOX-2 (MEOX2) . P50222
Proto-oncogene c-Rel (REL) . Q04864
Transcriptional adapter 2-alpha (TADA2A) . O75478
Other
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Coiled-coil domain-containing protein 85B (CCDC85B) CCDC85 family Q15834
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Golgin subfamily A member 7B (GOLGA7B) ERF4 family Q2TAP0
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Prelamin-A/C (LMNA) Intermediate filament family P02545
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 2-4 (KRTAP2-4) KRTAP type 2 family Q9BYR9
Protein LDOC1 (LDOC1) LDOC1 family O95751
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1) RPGRIP1 family Q96KN7
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Heat shock factor 2-binding protein (HSF2BP) . O75031
Melanoma-associated antigen 1 (MAGEA1) . P43355
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840