Details of the Target

General Information of Target

Target ID LDTP09293
Target Name Interleukin-17D (IL17D)
Gene Name IL17D
Gene ID 53342
Synonyms
Interleukin-17D; IL-17D; Interleukin-27; IL-27
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLVAGFLLALPPSWAAGAPRAGRRPARPRGCADRPEELLEQLYGRLAAGVLSAFHHTLQL
GPREQARNASCPAGGRPADRRFRPPTNLRSVSPWAYRISYDPARYPRYLPEAYCLCRGCL
TGLFGEEDVRFRSAPVYMPTVVLRRTPACAGGRSVYTEAYVTIPVGCTCVPEPEKDADSI
NSSIDKQGAKLLLGPNDAPAGP
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Family
IL-17 family
Subcellular location
Secreted
Function Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.
TTD ID
T41171
Uniprot ID
Q8TAD2
DrugMap ID
TTC5LTG
Ensemble ID
ENST00000304920.3
HGNC ID
HGNC:5984

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C31(1.12)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C31(1.12)  LDD1508  [1]
 LDCM0237  AC12 HEK-293T C31(0.90)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C31(1.07)  LDD1512  [1]
 LDCM0277  AC18 HEK-293T C31(1.20)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C31(0.97)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C31(0.96)  LDD1519  [1]
 LDCM0282  AC22 HEK-293T C31(0.96)  LDD1521  [1]
 LDCM0284  AC24 HEK-293T C31(0.97)  LDD1523  [1]
 LDCM0286  AC26 HEK-293T C31(1.13)  LDD1525  [1]
 LDCM0288  AC28 HEK-293T C31(1.48)  LDD1527  [1]
 LDCM0291  AC30 HEK-293T C31(1.10)  LDD1530  [1]
 LDCM0293  AC32 HEK-293T C31(1.07)  LDD1532  [1]
 LDCM0295  AC34 HEK-293T C31(1.10)  LDD1534  [1]
 LDCM0297  AC36 HEK-293T C31(1.04)  LDD1536  [1]
 LDCM0299  AC38 HEK-293T C31(1.05)  LDD1538  [1]
 LDCM0301  AC4 HEK-293T C31(0.91)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C31(0.93)  LDD1541  [1]
 LDCM0304  AC42 HEK-293T C31(1.12)  LDD1543  [1]
 LDCM0306  AC44 HEK-293T C31(1.08)  LDD1545  [1]
 LDCM0308  AC46 HEK-293T C31(1.24)  LDD1547  [1]
 LDCM0310  AC48 HEK-293T C31(0.97)  LDD1549  [1]
 LDCM0313  AC50 HEK-293T C31(0.88)  LDD1552  [1]
 LDCM0315  AC52 HEK-293T C31(0.97)  LDD1554  [1]
 LDCM0317  AC54 HEK-293T C31(0.94)  LDD1556  [1]
 LDCM0319  AC56 HEK-293T C31(0.90)  LDD1558  [1]
 LDCM0321  AC58 HEK-293T C31(1.08)  LDD1560  [1]
 LDCM0323  AC6 HEK-293T C31(1.05)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C31(0.89)  LDD1563  [1]
 LDCM0326  AC62 HEK-293T C31(0.85)  LDD1565  [1]
 LDCM0328  AC64 HEK-293T C31(0.82)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C31(0.95)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C31(1.05)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C31(1.16)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C31(1.06)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C31(0.84)  LDD1575  [1]
 LDCM0373  CL104 HEK-293T C31(1.13)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C31(1.03)  LDD1579  [1]
 LDCM0377  CL108 HEK-293T C31(1.13)  LDD1581  [1]
 LDCM0380  CL110 HEK-293T C31(0.92)  LDD1584  [1]
 LDCM0382  CL112 HEK-293T C31(0.88)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C31(0.80)  LDD1588  [1]
 LDCM0386  CL116 HEK-293T C31(1.18)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C31(1.11)  LDD1592  [1]
 LDCM0390  CL12 HEK-293T C31(1.35)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C31(1.32)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C31(0.95)  LDD1597  [1]
 LDCM0395  CL124 HEK-293T C31(0.97)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C31(0.49)  LDD1601  [1]
 LDCM0399  CL128 HEK-293T C31(1.08)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C31(0.90)  LDD1605  [1]
 LDCM0403  CL16 HEK-293T C31(0.94)  LDD1607  [1]
 LDCM0405  CL18 HEK-293T C31(1.18)  LDD1609  [1]
 LDCM0407  CL2 HEK-293T C31(0.99)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C31(0.94)  LDD1612  [1]
 LDCM0410  CL22 HEK-293T C31(0.97)  LDD1614  [1]
 LDCM0412  CL24 HEK-293T C31(0.98)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C31(1.08)  LDD1618  [1]
 LDCM0416  CL28 HEK-293T C31(1.24)  LDD1620  [1]
 LDCM0419  CL30 HEK-293T C31(0.97)  LDD1623  [1]
 LDCM0421  CL32 HEK-293T C31(1.02)  LDD1625  [1]
 LDCM0423  CL34 HEK-293T C31(1.23)  LDD1627  [1]
 LDCM0425  CL36 HEK-293T C31(0.90)  LDD1629  [1]
 LDCM0429  CL4 HEK-293T C31(1.00)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C31(1.12)  LDD1634  [1]
 LDCM0432  CL42 HEK-293T C31(1.08)  LDD1636  [1]
 LDCM0434  CL44 HEK-293T C31(1.03)  LDD1638  [1]
 LDCM0436  CL46 HEK-293T C31(0.93)  LDD1640  [1]
 LDCM0438  CL48 HEK-293T C31(1.01)  LDD1642  [1]
 LDCM0441  CL50 HEK-293T C31(0.97)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C31(1.09)  LDD1646  [1]
 LDCM0445  CL54 HEK-293T C31(1.14)  LDD1648  [1]
 LDCM0447  CL56 HEK-293T C31(0.92)  LDD1650  [1]
 LDCM0449  CL58 HEK-293T C31(0.95)  LDD1652  [1]
 LDCM0451  CL6 HEK-293T C31(1.39)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C31(0.97)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C31(1.27)  LDD1657  [1]
 LDCM0456  CL64 HEK-293T C31(1.18)  LDD1659  [1]
 LDCM0458  CL66 HEK-293T C31(1.00)  LDD1661  [1]
 LDCM0460  CL68 HEK-293T C31(0.82)  LDD1663  [1]
 LDCM0463  CL70 HEK-293T C31(0.95)  LDD1666  [1]
 LDCM0465  CL72 HEK-293T C31(1.19)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C31(1.26)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C31(1.12)  LDD1672  [1]
 LDCM0471  CL78 HEK-293T C31(1.14)  LDD1674  [1]
 LDCM0473  CL8 HEK-293T C31(1.03)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C31(0.94)  LDD1677  [1]
 LDCM0476  CL82 HEK-293T C31(1.09)  LDD1679  [1]
 LDCM0478  CL84 HEK-293T C31(0.85)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C31(1.17)  LDD1683  [1]
 LDCM0482  CL88 HEK-293T C31(0.91)  LDD1685  [1]
 LDCM0485  CL90 HEK-293T C31(3.09)  LDD1688  [1]
 LDCM0487  CL92 HEK-293T C31(1.22)  LDD1690  [1]
 LDCM0489  CL94 HEK-293T C31(1.06)  LDD1692  [1]
 LDCM0491  CL96 HEK-293T C31(1.04)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C31(0.92)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C31(1.10)  LDD1631  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Srf388 Antibody DLY89F

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402