Details of the Target

General Information of Target

Target ID LDTP08502
Target Name Neuron navigator 3 (NAV3)
Gene Name NAV3
Gene ID 89795
Synonyms
KIAA0938; POMFIL1; STEERIN3; Neuron navigator 3; Pore membrane and/or filament-interacting-like protein 1; Steerin-3; Unc-53 homolog 3; unc53H3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVLGVASKLRQPAVGSKPVHTALPIPNLGTTGSQHCSSRPLELTETESSMLSCQLALKS
TCEFGEKKPLQGKAKEKEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQII
ANEKVEDINGCPRSQSQMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLS
RYKQQQHHQQQYYQSLVELQQRVTHASPPSEASQAKTQQDMQSSLAARYATQSNHSGIAT
SQKKPTRLPGPSRVPAAGSSSKVQGASNLNRRSQSFNSIDKNKPPNYANGNEKDSSKGPQ
SSSGVNGNVQPPSTAGQPPASAIPSPSASKPWRSKSMNVKHSATSTMLTVKQSSTATSPT
PSSDRLKPPVSEGVKTAPSGQKSMLEKFKLVNARTALRPPQPPSSGPSDGGKDDDAFSES
GEMEGFNSGLNSGGSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQPKEKEEKNRDKNKVCT
EKPVKEEKDQVTEMAPKKTSKIASLIPKGSKTTAAKKESLIPSSSGIPKPGSKVPTVKQT
ISPGSTASKESEKFRTTKGSPSQSLSKPITMEKASASSCPAPLEGREAGQASPSGSCTMT
VAQSSGQSTGNGAVQLPQQQQHSHPNTATVAPFIYRAHSENEGTALPSADSCTSPTKMDL
SYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSSLRGTQISHSTLETTFDST
VTTEVNGRTIPNLTSRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSGTSRFIHTDPSRFM
YTTPLRRAAVSRLGNMSQIDMSEKASSDLDMSSEVDVGGYMSDGDILGKSLRTDDINSGY
MTDGGLNLYTRSLNRIPDTATSRDIIQRGVHDVTVDADSWDDSSSVSSGLSDTLDNISTD
DLNTTSSVSSYSNITVPSRKNTQLRTDSEKRSTTDETWDSPEELKKPEEDFDSHGDAGGK
WKTVSSGLPEDPEKAGQKASLSVSQTGSWRRGMSAQGGAPSRQKAGTSALKTPGKTDDAK
ASEKGKAPLKGSSLQRSPSDAGKSSGDEGKKPPSGIGRSTATSSFGFKKPSGVGSSAMIT
SSGATITSGSATLGKIPKSAAIGGKSNAGRKTSLDGSQNQDDVVLHVSSKTTLQYRSLPR
PSKSSTSGIPGRGGHRSSTSSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKE
KEKVAVSDSESVSLSGSPKSSPTSASACGAQGLRQPGSKYPDIASPTFRRLFGAKAGGKS
ASAPNTEGVKSSSVMPSPSTTLARQGSLESPSSGTGSMGSAGGLSGSSSPLFNKPSDLTT
DVISLSHSLASSPASVHSFTSGGLVWAANMSSSSAGSKDTPSYQSMTSLHTSSESIDLPL
SHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQLDRNTLPKKGLRYTPSSRQANQEEG
KEWLRSHSTGGLQDTGNQSPLVSPSAMSSSAAGKYHFSNLVSPTNLSQFNLPGPSMMRSN
SIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEEVHGSSLSLVSSTSSLYS
TAEEKAHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLGNMTGRLQSLTMTA
EQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPKDLRIRRQHSSESVSSINSAT
SHSSIGSGNDADSKKKKKKNWVNSRGSELRSSFKQAFGKKKSTKPPSSHSDIEELTDSSL
PASPKLPHNAGDCGSASMKPSQSASASPLVWPPKKRQNGPVIYKHRSRICECTEAEAEII
LQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRLKAETGNTA
KPTRPPSESSSSTSSSSSRQSLGLSLNNLNITEAVSSDILLDDAGDATGHKDGRSVKIIV
SISKGYGRAKDQKSQAYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSTSLGLSSDC
IASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQ
RYFNLLMEHHRIILSGPSGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKELQ
QYLANLAEQCSADNNGVELPVVIILDNLHHVGSLSDIFNGFLNCKYNKCPYIIGTMNQGV
SSSPNLELHHNFRWVLCANHTEPVKGFLGRYLRRKLIEIEIERNIRNNDLVKIIDWIPKT
WHHLNSFLETHSSSDVTIGPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMY
GKRTPWEDPSKWVLDTYPWSSATLPQESPALLQLRPEDVGYESCTSTKEATTSKHIPQTD
TEGDPLMNMLMKLQEAANYSSTQSCDSESTSHHEDILDSSLESTL
Target Bioclass
Other
Family
Nav/unc-53 family
Subcellular location
Nucleus outer membrane
Function Plays a role in cell migration. May be involved in neuron regeneration. May regulate IL2 production by T-cells.
Uniprot ID
Q8IVL0
Ensemble ID
ENST00000397909.7
HGNC ID
HGNC:15998

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.R247K .
A673 SNV: p.L1511V .
AGS SNV: p.S1548A .
CAL120 SNV: p.S39L; p.S1293C .
CCK81 SNV: p.V1544A; p.S2095P .
CCLP1 SNV: p.E1439Q DBIA    Probe Info 
CHL1 SNV: p.R681K .
CORL23 SNV: p.T600K .
DU145 SNV: p.S1001F;p.G1154C
Substitution: p.G1404F		 .
FADU SNV: p.H2093N .
HCC44 Deletion: p.S2024_N2044del .
HCT15 SNV: p.M796I; p.S1351N; p.L1378P .
HDQP1 SNV: p.R333L .
HEC1B SNV: p.G434V .
HGC27 SNV: p.A1021G .
HT SNV: p.C2324W .
HT115 Insertion: p.T499DfsTer10
SNV: p.S1059L;p.T2063A		 .
IGROV1 SNV: p.S1307N .
KMCH1 Substitution: p.G16K DBIA    Probe Info 
LNCaP clone FGC SNV: p.S909N .
MDAMB453 SNV: p.S523Y .
MEWO SNV: p.R919K .
MOLT4 SNV: p.L1517F .
NCIH1792 SNV: p.I2123T .
NCIH1793 SNV: p.A230G .
NCIH1944 SNV: p.W1346C .
NCIH2172 SNV: p.P522Q; p.S1226C .
NCIH2286 SNV: p.V263F; p.H1748Y .
NCIH358 SNV: p.H1993L .
NCIH446 SNV: p.C131S .
NCIH661 SNV: p.R636S .
NOMO1 SNV: p.Q1437E .
ONS76 SNV: p.T1280I .
OVCAR8 SNV: p.L2304M .
P31FUJ Insertion: p.Q401AfsTer8 .
PF382 SNV: p.S1459P .
REH SNV: p.L2192F .
SKMEL28 Deletion: p.T240VfsTer29 .
SNGM Insertion: p.Q401AfsTer8 .
SW1271 SNV: p.P483Q;p.Q2040K
Substitution: p.Y1363_Q1364delinsTer		 .
TE4 SNV: p.D1047G .
TF1 Deletion: p.D755MfsTer47 .
TYKNU SNV: p.T1815M .
UACC257 SNV: p.S1941F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K459(0.20)  LDD0277  [2]
BTD
 Probe Info  		C748(0.63)  LDD2125  [3]
IPM
 Probe Info  		C1228(2.63); C748(2.47); C479(1.78)  LDD1701  [3]
DBIA
 Probe Info  		C1228(1.17)  LDD0533  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C748(0.97)  LDD2130  [3]
 LDCM0216  AC100 HCT 116 C1228(1.17)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C1228(1.31)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C1228(1.23)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C1228(1.19)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C1228(1.18)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C1228(1.38)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C1228(1.46)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C1228(1.14)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C1228(1.31)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C1228(0.87)  LDD0542  [4]
 LDCM0227  AC110 HCT 116 C1228(0.94)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C1228(1.00)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C1228(1.30)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C1228(1.02)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C1228(0.74)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C1228(1.38)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C1228(1.59)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C1228(1.67)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C1228(1.60)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C1228(0.89)  LDD0553  [4]
 LDCM0238  AC120 HCT 116 C1228(1.27)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C1228(1.00)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C1228(0.87)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C1228(1.37)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C1228(0.92)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C1228(0.61)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C1228(0.85)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C1228(1.13)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C1228(0.70)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C1228(0.79)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C1228(0.76)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C1228(0.70)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C1228(1.10)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C1228(0.90)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C1228(1.15)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C1228(0.77)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C1228(0.90)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C1228(0.75)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C1228(1.13)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C1228(0.90)  LDD0575  [4]
 LDCM0260  AC140 HCT 116 C1228(1.08)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C1228(1.15)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C1228(0.82)  LDD0579  [4]
 LDCM0365  AC98 HCT 116 C1228(1.14)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C1228(1.00)  LDD0683  [4]
 LDCM0156  Aniline NCI-H1299 12.28  LDD0403  [1]
 LDCM0436  CL46 HCT 116 C1228(1.37)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C1228(1.01)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C1228(1.02)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C1228(0.74)  LDD0756  [4]
 LDCM0441  CL50 HCT 116 C1228(0.92)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C1228(1.11)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C1228(1.38)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C1228(0.96)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C1228(0.99)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C1228(1.09)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C1228(0.97)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C1228(1.14)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C1228(0.94)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C1228(0.81)  LDD0767  [4]
 LDCM0452  CL60 HCT 116 C1228(1.21)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C1228(1.10)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C1228(0.86)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C1228(1.08)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C1228(1.07)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C1228(0.96)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C1228(0.83)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C1228(0.90)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C1228(0.91)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C1228(1.10)  LDD0778  [4]
 LDCM0463  CL70 HCT 116 C1228(1.08)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C1228(0.97)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C1228(0.92)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C1228(1.14)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C1228(1.27)  LDD0784  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1228(1.16); C479(1.15)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C1228(0.99)  LDD0785  [4]
 LDCM0022  KB02 42-MG-BA C1228(1.39)  LDD2244  [7]
 LDCM0023  KB03 MDA-MB-231 C1228(2.63); C748(2.47); C479(1.78)  LDD1701  [3]
 LDCM0024  KB05 UACC257 C664(1.53)  LDD3325  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C748(0.63)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C748(0.34)  LDD2127  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840