Details of the Target

General Information of Target

Target ID LDTP08267
Target Name Zinc finger protein castor homolog 1 (CASZ1)
Gene Name CASZ1
Gene ID 54897
Synonyms
CST; SRG; ZNF693; Zinc finger protein castor homolog 1; Castor-related protein; Putative survival-related protein; Zinc finger protein 693
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLGTAEGTRCTDPPAGKPAMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQ
PRDQERSGPESGAARAPRSEEDKRRAVIEKWVNGEYSEEPAPTPVLGRIAREGLELPPEG
VYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASGEASSLRDYAAS
TMTEFLGMFGYDDQNTRDELARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYE
EYIRKLKAGEQLSWPAPSTKTEERVGKEVVGTLPGLRLPSSTAHLETKATILPLPSHSSV
QMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHLFKPGEGSPDMG
GAIAFKTGKVGRPSKYDVRGIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASL
SFNTPEYLKSTFSKTDSITTGTVSTVKNGLPTDKPAVTEDVNIYQKYIARFSGSQHCGHI
HCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRFSPLDDCSVYYH
GCHLNGKSTHYHCMQVGCNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADC
QFYGQKTTHFHCRRPGCTFTFKNKCDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCV
YSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSLLGAKDTEHEES
SNDDLVDFSALSSKNSSLSASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGL
PGSIPLALALSNSGLPTPTPYFPILAGRGSTSLPVGTPSLLGAVSSGSAASATPDTPTLV
ASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSATFDPGSGQQVT
PARFPPAQVKPEPGESTGAPGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNK
MSQGNPGLGSLLNIKAEAEGSPAAEPSPFLGKAVKALVQEKLAEPWKVYLRRFGTKDFCD
GQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEAAFPASAAETKP
PMAPSSPPVPPVTTATVSSLEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLP
ASPLATTSLENAKPQVKPGFLQFQENDPCLATDCKYANKFHFHCLFGNCKYVCKTSGKAE
SHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGCYFVTNITTKLP
WHIKKHEKAERRAANGFKYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSH
ARKHMRRMLGKNFDRVPPSQGPPGLMDAETDECMDYTGCSPGAMSSESSTMDRSCSSTPV
GNESTAAGNTISMPTASGAKKRFWIIEDMSPFGKRRKTASSRKMLDEGMMLEGFRRFDLY
EDCKDAACQFSLKVTHYHCTRENCGYKFCGRTHMYKHAQHHDRVDNLVLDDFKRFKASLS
CHFADCPFSGTSTHFHCLRCRFRCTDSTKVTAHRKHHGKQDVISAAGFCQFSSSADCAVP
DCKYKLKCSHFHCTFPGCRHTVVGMSQMDSHKRKHEKQERGEPAAEGPAPGPPISLDGSL
SLGAEPGSLLFLQSAAAGLGLALGDAGDPGPPDAAAPGPREGAAAAAAAAGESSQEDEEE
ELELPEEEAEDDEDEDDDEDDDDEDDDEDDDDEDLRTDSEESLPEAAAEAAGAGARTPAL
AALAALGAPGPAPTAASSP
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
Uniprot ID
Q86V15
Ensemble ID
ENST00000344008.5
HGNC ID
HGNC:26002

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.H667N .
A498 SNV: p.E1693Ter DBIA    Probe Info 
CHL1 SNV: p.A852G .
COLO678 SNV: p.A852G DBIA    Probe Info 
DU145 SNV: p.G1618S DBIA    Probe Info 
HCC15 SNV: p.D1703E DBIA    Probe Info 
HCC827 SNV: p.E1606Q .
HCT15 SNV: p.P707H .
HEC1B Deletion: p.P906RfsTer4 .
HS936T Substitution: p.P102L; p.P104L .
HT SNV: p.H1181R .
HT115 SNV: p.A641T; p.G1248D; p.W1261Ter .
IPC298 SNV: p.M1354I .
K562 SNV: p.L731M .
LNCaP clone FGC SNV: p.G1330V DBIA    Probe Info 
MELJUSO SNV: p.P922L .
MEWO SNV: p.E1693G DBIA    Probe Info 
MOLT4 SNV: p.P1127H .
NCIH1155 SNV: p.T1472M .
NCIH1993 SNV: p.G143V .
NCIH446 SNV: p.E241D .
NCIH716 SNV: p.G355A .
ONS76 SNV: p.V1454I .
RKO SNV: p.G604E DBIA    Probe Info 
RL952 SNV: p.A1040T .
SKNSH SNV: p.P905H .
SNGM SNV: p.S173L; p.Q506Ter DBIA    Probe Info 
SNU1 SNV: p.D1705V .
TF1 SNV: p.H692P .
TOV21G SNV: p.A234E; p.E1676D .
VMRCRCW SNV: p.T811P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C670(1.38)  LDD3311  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C11(0.97)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C11(1.03)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C11(1.10)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C11(0.97); C1203(1.12)  LDD1512  [3]
 LDCM0277  AC18 HEK-293T C11(1.02)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C11(1.25)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C11(0.93)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C11(1.11)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C11(1.02)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C11(0.94); C1203(1.04)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C1203(0.88)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C11(1.00)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C11(1.04)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C11(1.04)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C11(0.99)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C11(1.03)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C11(0.95); C1203(0.86)  LDD1530  [3]
 LDCM0293  AC32 HEK-293T C1203(0.97)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C11(1.05)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C11(1.17)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C11(1.04)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C11(0.98)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C11(1.06); C1203(0.92)  LDD1538  [3]
 LDCM0301  AC4 HEK-293T C11(1.07)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C1203(1.16)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C11(1.04)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C11(1.21)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C11(1.16)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C11(1.04)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C11(1.07); C1203(0.93)  LDD1547  [3]
 LDCM0310  AC48 HEK-293T C1203(0.98)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C11(0.98)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C11(1.08)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C11(1.15)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C11(1.19)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C11(1.08)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C11(1.07); C1203(1.09)  LDD1556  [3]
 LDCM0319  AC56 HEK-293T C1203(1.01)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C11(1.03)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C11(1.01)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C11(1.00); C1203(1.06)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C11(1.02)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C11(0.98)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C11(0.90); C1203(0.91)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C1203(0.95)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C1203(0.94)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C11(0.94)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C1203(1.08)  LDD1514  [3]
 LDCM0368  CL10 HEK-293T C11(1.22); C1203(1.32)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C11(0.93)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C11(0.97)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C11(1.03)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C11(1.00)  LDD1577  [3]
 LDCM0375  CL106 HEK-293T C11(1.02)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C11(1.01)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C11(1.05)  LDD1581  [3]
 LDCM0380  CL110 HEK-293T C11(1.00)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C11(1.05)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C11(1.04)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C11(1.01)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C11(1.18)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C11(0.96)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C11(1.09)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C11(1.18)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C1203(1.10)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C11(1.08)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C11(1.11)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C11(1.01)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C11(1.04)  LDD1599  [3]
 LDCM0397  CL126 HEK-293T C11(1.11)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C11(1.04)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C11(0.99)  LDD1603  [3]
 LDCM0401  CL14 HEK-293T C11(1.18)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C11(1.07)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C11(1.08)  LDD1607  [3]
 LDCM0405  CL18 HEK-293T C11(1.16)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C11(1.32)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C11(1.13)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C11(1.34)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C11(1.19)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C11(1.41); C1203(0.96)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C1203(1.16)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C11(0.93)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C11(1.04)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C11(0.95)  LDD1620  [3]
 LDCM0418  CL3 HEK-293T C11(1.10)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C11(1.03)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C11(1.23)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C11(1.20)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C11(0.99)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C11(1.25); C1203(1.02)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C1203(1.00)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C11(0.99)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C11(1.00)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C11(0.97)  LDD1634  [3]
 LDCM0432  CL42 HEK-293T C11(1.12)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C11(1.16)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C11(1.15)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C11(1.18)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C11(1.31); C1203(1.09)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C1203(0.91)  LDD1642  [3]
 LDCM0441  CL50 HEK-293T C11(0.84)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C11(1.01)  LDD1646  [3]
 LDCM0445  CL54 HEK-293T C11(1.11)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C11(1.20)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C11(1.07)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C11(1.23)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C11(1.40); C1203(0.90)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C11(1.12)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C1203(1.15)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C11(1.02)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C11(1.05)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C11(1.02)  LDD1659  [3]
 LDCM0458  CL66 HEK-293T C11(1.09)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C11(1.26)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C11(1.21)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C11(1.26)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C11(1.22)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C11(1.37); C1203(1.21)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C1203(1.01)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C11(1.07)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C11(1.04)  LDD1672  [3]
 LDCM0471  CL78 HEK-293T C11(1.09)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C11(1.22)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C11(1.01)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C11(1.20)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C11(1.37)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C11(1.18); C1203(1.17)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C1203(0.96)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C11(0.97)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C11(1.09)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C11(0.93)  LDD1685  [3]
 LDCM0484  CL9 HEK-293T C11(1.32)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C11(0.97)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C11(1.11)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C11(1.18)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C11(1.21)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C11(1.27); C1203(1.50)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C1203(0.95)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C11(1.06)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C11(1.03)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C11(1.03)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C11(1.14)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C11(0.88)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C35(1.17); C11(0.96)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C35(1.06); C11(0.95)  LDD1497  [3]
 LDCM0024  KB05 G361 C670(1.38)  LDD3311  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402