Details of the Target

General Information of Target

Target ID LDTP08188
Target Name Ubiquitin carboxyl-terminal hydrolase 37 (USP37)
Gene Name USP37
Gene ID 57695
Synonyms
KIAA1594; Ubiquitin carboxyl-terminal hydrolase 37; EC 3.4.19.12; Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNV
VLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSF
GAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIA
RTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYL
TSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKR
SLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLF
SLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAER
FSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLE
FEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEK
CGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKP
PFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDELKRSV
ALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLEISKRDA
SPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDE
NKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELS
LQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGS
TSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLET
EKNSQSLSTEVGKTTRQAL
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Peptidase C19 family
Function
Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response. Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1. Plays also an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability. Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM. Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM. Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI. Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination.
TTD ID
T10899
Uniprot ID
Q86T82
DrugMap ID
TTJDELN
Ensemble ID
ENST00000258399.8
HGNC ID
HGNC:20063

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.D832G .
HT115 SNV: p.H41N .
HT3 SNV: p.E750K .
JHH7 SNV: p.K639N .
KYSE150 SNV: p.A109S .
MCC13 Substitution: p.P158L .
MDAMB453 SNV: p.E707K .
MFE296 SNV: p.R511G .
NCIH1299 SNV: p.S249N .
OZ SNV: p.N256S .
SAOS2 SNV: p.Y322F .
UACC62 SNV: p.D865E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C686(3.60)  LDD3342  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]
NAIA_5
 Probe Info  		N.A.  LDD2225  [3]
IPM
 Probe Info  		C398(0.00); C318(0.00)  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C398(0.82)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C398(0.95); C473(1.15)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C398(1.11)  LDD1509  [5]
 LDCM0259  AC14 HEK-293T C398(0.95); C318(1.16); C473(0.86)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C398(1.06)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C398(0.97)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C398(0.96); C473(0.93)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C398(1.18)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C398(0.93); C473(1.02)  LDD1518  [5]
 LDCM0281  AC21 HEK-293T C398(0.91); C473(0.89)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C398(1.04); C318(1.04); C473(1.01)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C398(1.03)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C318(1.23); C473(0.85)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C398(0.90)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C398(1.01); C473(1.08)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C398(1.11)  LDD1526  [5]
 LDCM0289  AC29 HEK-293T C398(1.00); C473(0.97)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C398(1.02)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C398(1.00); C318(1.14); C473(1.12)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C398(1.04)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C318(1.23); C473(0.79)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C398(0.93)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C398(0.96); C473(1.18)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C398(1.11)  LDD1535  [5]
 LDCM0298  AC37 HEK-293T C398(0.88); C473(1.00)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C398(0.99); C318(1.30); C473(0.85)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C398(0.98)  LDD1539  [5]
 LDCM0302  AC40 HEK-293T C318(1.13); C473(0.82)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C398(0.78)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C398(0.95); C473(0.92)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C398(1.00)  LDD1544  [5]
 LDCM0307  AC45 HEK-293T C398(0.89); C473(1.00)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C398(0.98); C318(1.10); C473(0.94)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C398(0.92)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C318(1.10); C473(0.85)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C398(0.90)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C398(0.93); C473(0.95)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C398(0.92); C473(1.07)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C398(1.03)  LDD1553  [5]
 LDCM0316  AC53 HEK-293T C398(0.92); C473(1.00)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C398(0.95); C318(1.16); C473(0.99)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C398(0.91)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C318(1.07); C473(0.90)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C398(0.95)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C398(0.94); C473(1.09)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C398(1.04)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C398(1.12); C318(1.27); C473(0.91)  LDD1562  [5]
 LDCM0325  AC61 HEK-293T C398(0.87); C473(1.05)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C398(1.04); C318(1.02); C473(1.00)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C398(0.97)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C318(1.13); C473(0.92)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C398(0.93)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C318(0.98); C473(0.86)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C398(0.93); C473(0.97)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C398(0.93)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C318(1.44); C473(1.03)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C398(1.07); C318(1.13); C473(1.24)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C398(2.10); C318(1.35); C473(1.31)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C473(1.08)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C398(1.03); C318(1.14); C473(0.90)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C398(1.11); C318(1.03)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C398(0.95)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C473(0.98)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C398(0.95); C318(1.06); C473(1.06)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C398(1.15); C318(1.11)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C398(0.83)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C473(1.02)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C398(0.98); C318(1.03); C473(0.87)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C398(1.66)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C398(1.21); C318(0.93)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C398(1.03)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C473(0.92)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C398(0.87); C318(1.04); C473(1.02)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C398(0.98); C318(1.06)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C398(0.90)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C473(0.94)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C398(0.93); C318(1.10); C473(1.02)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C398(0.93); C318(1.17)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C398(0.95)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C318(1.50); C473(1.05)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C473(0.98)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C398(0.88); C318(1.25); C473(1.03)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C398(1.00); C318(1.30)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C398(1.24)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C473(0.92)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C398(0.89); C318(1.17); C473(1.06)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C398(0.96); C318(1.11)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C398(0.97)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C473(1.09)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C398(1.03); C318(1.41); C473(1.19)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C398(1.04); C318(0.97)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C398(1.08)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C473(0.98)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C398(1.19)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C398(1.09); C473(0.92)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C398(1.31)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C398(0.90); C318(1.04)  LDD1611  [5]
 LDCM0409  CL21 HEK-293T C398(1.27); C473(1.17)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C398(1.87); C318(1.42); C473(1.00)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C398(1.51)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C318(1.36); C473(1.15)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C398(1.23); C318(1.05); C473(0.95)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C398(0.96); C318(1.17)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C398(0.98)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C473(0.97)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C398(1.08)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C398(0.87)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C398(0.98); C473(1.01)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C398(1.36)  LDD1624  [5]
 LDCM0422  CL33 HEK-293T C398(1.71); C473(1.37)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C398(1.56); C318(1.36); C473(1.08)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C398(1.98)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C318(1.53); C473(1.19)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C398(0.89); C318(1.05); C473(0.78)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C398(0.94)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C473(1.06)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C473(1.11)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C398(0.92)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C398(1.05); C473(0.96)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C398(1.30)  LDD1637  [5]
 LDCM0435  CL45 HEK-293T C398(1.23); C473(1.00)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C398(1.46); C318(1.32); C473(1.04)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C398(1.53)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C318(1.74); C473(1.03)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C398(0.89); C318(1.11); C473(0.95)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C398(1.06)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C398(0.96); C318(1.03)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C473(1.03)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C398(1.08)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C398(1.18); C473(1.36)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C398(1.38)  LDD1649  [5]
 LDCM0448  CL57 HEK-293T C398(1.21); C473(1.19)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C398(1.75); C318(1.72); C473(1.00)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C398(1.31)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C398(1.18); C473(0.97)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C318(1.61); C473(1.07)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C398(0.87); C318(1.06); C473(1.04)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C398(0.97); C318(1.17)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C398(1.03)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C473(1.11)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C398(1.01)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C398(1.05); C473(0.91)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C398(1.31)  LDD1662  [5]
 LDCM0461  CL69 HEK-293T C398(1.04); C473(1.09)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C398(1.18)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C398(1.42); C318(1.40); C473(0.91)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C398(1.41)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C318(1.62); C473(0.96)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C398(0.92); C318(1.12); C473(0.86)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C398(0.97); C318(1.05)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C473(0.94)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C398(1.08)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C398(1.07); C473(1.12)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C398(1.24)  LDD1675  [5]
 LDCM0475  CL81 HEK-293T C398(1.19); C473(1.05)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C398(1.29); C318(1.36); C473(1.05)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C398(1.33)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C318(1.47); C473(1.02)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C398(0.75); C318(1.09); C473(0.96)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C398(0.85); C318(1.03)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C398(0.83)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C473(0.96)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C398(0.89)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C398(1.30); C473(1.09)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C398(1.27); C473(1.55)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C398(1.13)  LDD1689  [5]
 LDCM0488  CL93 HEK-293T C398(1.13); C473(1.10)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C398(1.19); C318(1.40); C473(1.00)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C398(1.52)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C318(1.51); C473(1.03)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C398(1.05); C318(1.15); C473(0.85)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C398(0.92); C318(1.07)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C398(0.96)  LDD1697  [5]
 LDCM0634  CY-0357 Hep-G2 C318(0.71)  LDD2228  [3]
 LDCM0495  E2913 HEK-293T C398(1.00)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C398(0.96)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C398(0.99); C318(1.18)  LDD1631  [5]
 LDCM0022  KB02 A101D C686(2.13)  LDD2250  [1]
 LDCM0023  KB03 A-375 C686(2.59)  LDD2672  [1]
 LDCM0024  KB05 NCI-H1155 C686(3.60)  LDD3342  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402