Details of the Target

General Information of Target

Target ID LDTP08060
Target Name Polycystin-1-like protein 3 (PKD1L3)
Gene Name PKD1L3
Gene ID 342372
Synonyms
Polycystin-1-like protein 3; Polycystin-1L3; PC1-like 3 protein; Polycystic kidney disease protein 1-like 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFFKGGSWLWLYIRTSIILGSELNSPAPHGQNNCYQLNRFQCSFEEAQHYCHVQRGFLAH
IWNKEVQDLIRDYLEEGKKWWIGQNVMPLKKHQDNKYPADVAANGPPKPLSCTYLSRNFI
RISSKGDKCLLKYYFICQTGDFLDGDAHYERNGNNSHLYQRHKKTKRGVAIARDKMPPGP
GHLPTTCHYPLPAHLSKTLCHPISQFPSVLSSITSQVTSAASEPSSQPLPVITQLTMPVS
VTHAGQSLAETTSSPKEEGHPNTFTSYLQVSLQKASGQVIDEIAGNFSRAVHGLQALNKL
QEACEFLQKLTALTPRFSKPAQVNLINSLIYLSEELLRIPFQNNNSLGFKVPPTVCPFHS
LNNVTKAGEGSWLESKRHTEPVEDILEMSLVEFGNIGEAFLEQNQSPESSVTLTSANATL
LLSRQNISTLPLSSYTLGHPAPVRLGFPSALALKELLNKHPGVNVQITGLAFNPFKDLDN
RNIVGSIGSVLLSANRKLLQVHDLMEDIEIMLWRNVSLETHPTSLNMSTHQLTITVNVTS
LEKSLIVSIDPDSPLLMTLYLGFQYQPNCTHFHLNITLPKDKVWQKDEEYTWVLNPEHLQ
HGIGTYYITAVLSERQEGAQQTPSLVSVITAVTQCYYWEIHNQTWSSAGCQVGPQSTILR
TQCLCNHLTFFASDFFVVPRTVNVEDTIKLFLRVTNNPVGVSLLASLLGFYVITVVWARK
KDQADMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLC
DPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHF
LCNCWLAVDLGDCELDRVFIPVSKRELFSFRHLFSSMIVEKFTQDYLWLSIATRHPWNQF
TRVQRLSCCMTLLLCNMVINVMFWKINSTTAKRDEQMRPFAVAWSELLVSIHTAVILFPI
NLVIGRLFPLIEPQETLPLFPPIQASCLSDASVEPLSATMVVEELKETVRFLLRRNTYLL
SKCEQPPWSSWDITKLVKLLSSLVSSHLEGQGCHQQGERHWARVVPENHHHFCCYLHRVL
QRLKSHLGTLGLTQGHQSCDFLDAASQLQKLQELLETHILPTEQEPSREVTSFAILSSEE
GKKPISNGLSKWLTSVCWLLLGFTSLASAFFTALYSLELSKDQATSWMISIILSVLQNIF
ISQPVKVVFFTFLYSLMMSRMPRLNKENEQQTKRILALLAKCSSSVPGSRDKNNPVYVAP
AINSPTKHPERTLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSH
QFSEIKLLQDFYPWANHILLPSLYGDYRGKNAVLEPSHCKCGVQLIFQIPRTKTYEKVDE
GQLAFCDNGHTCGRPKSLFPGLHLRRFSYICSPRPMVLIPTDELHERLTSKNENGFSYIM
RGAFFTSLRLESFTSLQMSKKGCVWSIISQVIYYLLVCYYAFIQGCQLKQQKWRFFTGKR
NILDTSIILISFILLGLDMKSISLHKKNMARYRDDQDRFISFYEAVKVNSAATHLVGFPV
LLATVQLWNLLRHSPRLRVISRTLSRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDY
RTFFSSAVTVVGLLMGISHQEEVFALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGK
ERKSLKKEAALIDTLLQKLSNLLGISWPQKTSSEQAATTAVGSDTEVLDELP
Target Bioclass
Transporter and channel
Family
Polycystin family
Subcellular location
Cell membrane
Function
Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
Uniprot ID
Q7Z443
Ensemble ID
ENST00000620267.2
HGNC ID
HGNC:21716

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1242(0.80)  LDD1508  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C1242(0.80)  LDD1508  [1]
 LDCM0237  AC12 HEK-293T C1242(1.18)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C1242(1.15)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C1242(1.13); C1023(1.19); C1361(1.11)  LDD1513  [1]
 LDCM0277  AC18 HEK-293T C1242(0.82)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C1242(0.87)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C1242(1.15)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C1242(1.05)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C1242(1.10)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C1242(1.01); C1023(1.16); C1361(1.08)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C1242(1.09)  LDD1523  [1]
 LDCM0286  AC26 HEK-293T C1242(1.16)  LDD1525  [1]
 LDCM0288  AC28 HEK-293T C1242(1.10)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C1242(1.16)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C1242(1.19)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C1242(1.11); C1023(1.07); C1361(0.98)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C1242(1.04)  LDD1532  [1]
 LDCM0295  AC34 HEK-293T C1242(0.86)  LDD1534  [1]
 LDCM0297  AC36 HEK-293T C1242(1.12)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C1242(1.11)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C1242(1.19)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C1242(1.30); C1023(1.12); C1361(1.16)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C1242(0.93)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C1242(0.99)  LDD1541  [1]
 LDCM0304  AC42 HEK-293T C1242(1.20)  LDD1543  [1]
 LDCM0306  AC44 HEK-293T C1242(1.31)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C1242(1.06)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C1242(1.20)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C1242(1.07); C1023(1.35); C1361(1.16)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C1242(1.37)  LDD1549  [1]
 LDCM0312  AC5 HEK-293T C1242(0.94)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C1242(1.01)  LDD1552  [1]
 LDCM0315  AC52 HEK-293T C1242(1.17)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C1242(1.10)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C1242(1.09)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C1242(1.06); C1023(1.23); C1361(1.09)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C1242(1.06)  LDD1558  [1]
 LDCM0321  AC58 HEK-293T C1242(1.05)  LDD1560  [1]
 LDCM0323  AC6 HEK-293T C1242(1.05)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C1242(1.00)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C1242(1.04)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C1242(1.17)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C1242(0.91); C1023(1.26); C1361(1.18)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C1242(1.14)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C1242(1.11); C1023(0.96); C1361(0.93)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C1242(0.98)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C1242(1.06)  LDD1511  [1]
 LDCM0275  AKOS034007705 HEK-293T C1242(1.41)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C1242(0.95)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C1242(0.73)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C1242(0.87)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C1242(0.92)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C1242(0.96)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C1242(3.52); C1023(0.99); C1361(2.02)  LDD1583  [1]
 LDCM0383  CL113 HEK-293T C1242(0.90)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C1242(0.91)  LDD1591  [1]
 LDCM0390  CL12 HEK-293T C1242(0.96)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C1242(1.01)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C1242(0.74)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C1242(0.99)  LDD1604  [1]
 LDCM0405  CL18 HEK-293T C1242(1.70)  LDD1609  [1]
 LDCM0408  CL20 HEK-293T C1242(4.17)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C1242(2.13)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C1242(1.06)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C1242(3.15); C1023(0.98); C1361(2.09)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C1242(1.10)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C1242(0.74)  LDD1617  [1]
 LDCM0419  CL30 HEK-293T C1242(1.46)  LDD1623  [1]
 LDCM0421  CL32 HEK-293T C1242(3.40)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C1242(1.68)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C1242(1.26)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C1242(3.64); C1023(1.08); C1361(2.74)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C1242(1.09)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C1242(0.81)  LDD1630  [1]
 LDCM0432  CL42 HEK-293T C1242(1.30)  LDD1636  [1]
 LDCM0434  CL44 HEK-293T C1242(2.63)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C1242(1.96)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C1242(1.22)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C1242(3.74); C1023(1.08); C1361(2.06)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C1242(1.09)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C1242(0.77)  LDD1643  [1]
 LDCM0445  CL54 HEK-293T C1242(1.70)  LDD1648  [1]
 LDCM0447  CL56 HEK-293T C1242(2.26)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C1242(1.84)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C1242(1.26)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C1242(3.67); C1023(1.51); C1361(2.21)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C1242(1.30)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C1242(1.11)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C1242(0.83)  LDD1656  [1]
 LDCM0458  CL66 HEK-293T C1242(1.33)  LDD1661  [1]
 LDCM0460  CL68 HEK-293T C1242(2.37)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C1242(1.82)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C1242(1.15)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C1242(3.32); C1023(1.09); C1361(1.81)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C1242(1.09)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C1242(0.75)  LDD1669  [1]
 LDCM0471  CL78 HEK-293T C1242(1.81)  LDD1674  [1]
 LDCM0473  CL8 HEK-293T C1242(1.59)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C1242(1.93)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C1242(1.86)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C1242(1.05)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C1242(2.84); C1023(1.10); C1361(1.02)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C1242(1.04)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C1242(0.70)  LDD1682  [1]
 LDCM0484  CL9 HEK-293T C1242(1.84)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C1242(1.03)  LDD1688  [1]
 LDCM0487  CL92 HEK-293T C1242(1.39)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C1242(1.55)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C1242(1.14)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C1242(1.85); C1023(0.73); C1361(2.20)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C1242(1.09)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C1242(0.81)  LDD1695  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255