Details of the Target

General Information of Target

Target ID LDTP07648
Target Name Zinc finger protein 322 (ZNF322)
Gene Name ZNF322
Gene ID 79692
Synonyms
ZNF322A; ZNF388; ZNF489; Zinc finger protein 322; Zinc finger protein 322A; Zinc finger protein 388; Zinc finger protein 489
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYTSEEKCNQRTQKRKIYNVCPRKGKKIFIHMHEIIQIDGHIYQCLECKQNFCENLALIM
CERTHTGEKPYKCDMCEKTFVQSSDLTSHQRIHNYEKPYKCSKCEKSFWHHLALSGHQRT
HAGKKFYTCDICGKNFGQSSDLLVHQRSHTGEKPYLCSECDKCFSRSTNLIRHRRTHTGE
KPFKCLECEKAFSGKSDLISHQRTHTGERPYKCNKCEKSYRHRSAFIVHKRVHTGEKPYK
CGACEKCFGQKSDLIVHQRVHTGEKPYKCLECMRSFTRSANLIRHQATHTHTFKCLEYEK
SFNCSSDLIVHQRIHMEEKPHQWSACESGFLLGMDFVAQQKMRTQTEELHYKYTVCDKSF
HQSSALLQHQTVHIGEKPFVCNVSEKGLELSPPHASEASQMS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Cytoplasm
Function
Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells. Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes. Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly. Promotes inhibition of MAPK signaling during embryonic stem cell differentiation.
Uniprot ID
Q6U7Q0
Ensemble ID
ENST00000415922.7
HGNC ID
HGNC:23640

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C381(1.22)  LDD1511  [2]
HHS-465
 Probe Info  		K69(0.00); K72(0.00); Y71(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C381(1.14)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C381(1.13)  LDD1513  [2]
 LDCM0281  AC21 HEK-293T C381(1.16)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C381(1.01)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C381(1.07)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C381(1.03)  LDD1523  [2]
 LDCM0289  AC29 HEK-293T C381(0.86)  LDD1528  [2]
 LDCM0291  AC30 HEK-293T C381(0.97)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C381(0.93)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C381(0.94)  LDD1532  [2]
 LDCM0298  AC37 HEK-293T C381(1.21)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C381(1.03)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C381(1.16)  LDD1539  [2]
 LDCM0302  AC40 HEK-293T C381(1.10)  LDD1541  [2]
 LDCM0307  AC45 HEK-293T C381(1.12)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C381(1.14)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C381(1.14)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C381(1.03)  LDD1549  [2]
 LDCM0312  AC5 HEK-293T C381(1.02)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C381(0.96)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C381(1.05)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C381(1.13)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C381(1.04)  LDD1558  [2]
 LDCM0323  AC6 HEK-293T C381(1.05)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C381(1.07)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C381(1.08)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C381(1.10)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C381(1.08)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C381(1.11)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C381(1.09)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C381(1.22)  LDD1511  [2]
 LDCM0275  AKOS034007705 HEK-293T C381(1.07)  LDD1514  [2]
 LDCM0368  CL10 HEK-293T C381(1.07)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C381(0.82)  LDD1573  [2]
 LDCM0371  CL102 HEK-293T C381(1.02)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C381(1.12)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C381(0.98)  LDD1577  [2]
 LDCM0375  CL106 HEK-293T C381(0.93)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C381(1.05)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C381(0.70)  LDD1581  [2]
 LDCM0379  CL11 HEK-293T C381(1.34)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C381(0.99)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C381(0.95)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C381(0.73)  LDD1586  [2]
 LDCM0384  CL114 HEK-293T C381(1.03)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C381(1.18)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C381(1.02)  LDD1590  [2]
 LDCM0388  CL118 HEK-293T C381(1.01)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C381(0.96)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C381(1.29)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C381(0.88)  LDD1595  [2]
 LDCM0393  CL122 HEK-293T C381(1.03)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C381(1.04)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C381(1.00)  LDD1599  [2]
 LDCM0397  CL126 HEK-293T C381(1.21)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C381(1.14)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C381(1.07)  LDD1603  [2]
 LDCM0401  CL14 HEK-293T C381(1.12)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C381(1.04)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C381(1.09)  LDD1607  [2]
 LDCM0407  CL2 HEK-293T C381(1.18)  LDD1611  [2]
 LDCM0409  CL21 HEK-293T C381(1.23)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C381(1.18)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C381(1.30)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C381(1.35)  LDD1616  [2]
 LDCM0414  CL26 HEK-293T C381(0.95)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C381(1.14)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C381(0.90)  LDD1620  [2]
 LDCM0418  CL3 HEK-293T C381(1.12)  LDD1622  [2]
 LDCM0422  CL33 HEK-293T C381(1.12)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C381(1.16)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C381(1.23)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C381(1.17)  LDD1629  [2]
 LDCM0428  CL39 HEK-293T C381(0.98)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C381(0.93)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C381(0.81)  LDD1634  [2]
 LDCM0435  CL45 HEK-293T C381(1.13)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C381(1.14)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C381(1.24)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C381(1.07)  LDD1642  [2]
 LDCM0441  CL50 HEK-293T C381(1.00)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C381(1.39)  LDD1646  [2]
 LDCM0448  CL57 HEK-293T C381(1.41)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C381(1.20)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C381(1.16)  LDD1653  [2]
 LDCM0452  CL60 HEK-293T C381(1.15)  LDD1655  [2]
 LDCM0454  CL62 HEK-293T C381(1.04)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C381(1.25)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C381(1.10)  LDD1659  [2]
 LDCM0461  CL69 HEK-293T C381(1.24)  LDD1664  [2]
 LDCM0463  CL70 HEK-293T C381(1.19)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C381(1.17)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C381(1.19)  LDD1668  [2]
 LDCM0467  CL74 HEK-293T C381(1.07)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C381(1.06)  LDD1672  [2]
 LDCM0475  CL81 HEK-293T C381(1.16)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C381(1.15)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C381(1.25)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C381(1.10)  LDD1681  [2]
 LDCM0480  CL86 HEK-293T C381(1.20)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C381(0.93)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C381(0.88)  LDD1685  [2]
 LDCM0484  CL9 HEK-293T C381(1.38)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C381(1.36)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C381(1.26)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C381(1.29)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C381(1.06)  LDD1694  [2]
 LDCM0493  CL98 HEK-293T C381(0.91)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C381(1.19)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C381(1.05)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C381(0.90)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C381(1.06)  LDD1631  [2]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010