Details of the Target

General Information of Target

Target ID LDTP07558
Target Name Alpha/beta hydrolase domain-containing protein 17C (ABHD17C)
Gene Name ABHD17C
Gene ID 58489
Synonyms
FAM108C1; Alpha/beta hydrolase domain-containing protein 17C; Abhydrolase domain-containing protein 17C; EC 3.1.2.22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEPGPRMNGFSLGELCWLFCCPPCPSRIAAKLAFLPPEPTYTVLAPEQRGAGASAPAPA
QATAAAAAAQPAPQQPEEGAGAGPGACSLHLSERADWQYSQRELDAVEVFFSRTARDNRL
GCMFVRCAPSSRYTLLFSHGNAVDLGQMCSFYIGLGSRINCNIFSYDYSGYGVSSGKPSE
KNLYADIDAAWQALRTRYGVSPENIILYGQSIGTVPTVDLASRYECAAVILHSPLMSGLR
VAFPDTRKTYCFDAFPSIDKISKVTSPVLVIHGTEDEVIDFSHGLAMYERCPRAVEPLWV
EGAGHNDIELYAQYLERLKQFISHELPNS
Target Bioclass
Enzyme
Family
AB hydrolase superfamily, ABHD17 family
Subcellular location
Recycling endosome membrane
Function Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95.
Uniprot ID
Q6PCB6
Ensemble ID
ENST00000258884.5
HGNC ID
HGNC:26925

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MEWO Substitution: p.K260I DBIA    Probe Info 
NCIH2291 SNV: p.E108K .
SF295 SNV: p.P37S .
SKNAS SNV: p.M1? .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C122(2.30)  LDD3346  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C122(1.11)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C122(1.44)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C122(1.45)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C122(0.87)  LDD1510  [5]
 LDCM0270  AC15 HEK-293T C122(0.89)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C122(1.01)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C122(1.13)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C122(1.18)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C122(1.19)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C122(0.84)  LDD1519  [5]
 LDCM0283  AC23 HEK-293T C122(1.07)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C122(0.96)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C122(0.96)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C122(1.02)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C122(1.26)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C122(1.07)  LDD1527  [5]
 LDCM0290  AC3 HEK-293T C122(1.06)  LDD1529  [5]
 LDCM0292  AC31 HEK-293T C122(0.97)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C122(1.14)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C122(0.97)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C122(1.01)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C122(0.94)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C122(1.08)  LDD1536  [5]
 LDCM0300  AC39 HEK-293T C122(0.75)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C122(1.26)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C122(1.28)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C122(1.01)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C122(1.17)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C122(1.02)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C122(0.97)  LDD1545  [5]
 LDCM0309  AC47 HEK-293T C122(1.11)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C122(1.08)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C122(1.02)  LDD1550  [5]
 LDCM0313  AC50 HEK-293T C122(1.08)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C122(1.09)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C122(0.90)  LDD1554  [5]
 LDCM0318  AC55 HEK-293T C122(1.15)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C122(1.15)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C122(1.34)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C122(1.04)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C122(0.98)  LDD1561  [5]
 LDCM0324  AC60 HEK-293T C122(0.86)  LDD1563  [5]
 LDCM0327  AC63 HEK-293T C122(0.89)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C122(1.14)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C122(0.85)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C122(1.14)  LDD1569  [5]
 LDCM0356  AKOS034007680 HEK-293T C122(1.07)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C122(1.07)  LDD1514  [5]
 LDCM0369  CL100 HEK-293T C122(1.20); C251(1.01)  LDD1573  [5]
 LDCM0371  CL102 HEK-293T C122(0.94)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C122(1.27)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C122(0.81); C251(1.03)  LDD1577  [5]
 LDCM0375  CL106 HEK-293T C122(1.12)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C122(0.81)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C122(0.99); C251(1.14)  LDD1581  [5]
 LDCM0379  CL11 HEK-293T C122(1.48)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C122(1.24)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C122(1.33)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C122(1.09); C251(1.12)  LDD1586  [5]
 LDCM0384  CL114 HEK-293T C122(1.03)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C122(0.84)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C122(1.33); C251(1.06)  LDD1590  [5]
 LDCM0388  CL118 HEK-293T C122(0.91)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C122(0.80)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C122(1.04)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C122(0.93); C251(1.14)  LDD1595  [5]
 LDCM0393  CL122 HEK-293T C122(1.10)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C122(1.19)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C122(1.11); C251(1.03)  LDD1599  [5]
 LDCM0397  CL126 HEK-293T C122(1.01)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C122(1.01)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C122(1.35); C251(1.00)  LDD1603  [5]
 LDCM0401  CL14 HEK-293T C122(0.81)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C122(1.41)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C122(0.89); C251(1.03)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C122(0.94)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C122(1.02)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C122(1.17)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C122(0.96)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C122(0.93)  LDD1612  [5]
 LDCM0411  CL23 HEK-293T C122(0.77)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C122(1.14)  LDD1616  [5]
 LDCM0414  CL26 HEK-293T C122(0.97)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C122(0.92)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C122(1.13); C251(0.93)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C122(1.11)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C122(0.88)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C122(1.05)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C122(1.07)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C122(0.76)  LDD1625  [5]
 LDCM0424  CL35 HEK-293T C122(0.97)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C122(1.36)  LDD1629  [5]
 LDCM0428  CL39 HEK-293T C122(1.02)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C122(0.88); C251(1.00)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C122(1.35); C251(0.88)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C122(1.07)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C122(0.89)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C122(1.02)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C122(0.77)  LDD1638  [5]
 LDCM0437  CL47 HEK-293T C122(1.00)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C122(1.16)  LDD1642  [5]
 LDCM0440  CL5 HEK-293T C122(0.98)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C122(0.79)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C122(1.09); C251(0.97)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C122(1.24)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C122(1.16)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C122(1.01)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C122(0.93)  LDD1650  [5]
 LDCM0450  CL59 HEK-293T C122(0.80)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C122(1.05)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C122(1.19)  LDD1655  [5]
 LDCM0454  CL62 HEK-293T C122(0.85)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C122(0.81)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C122(1.02); C251(1.13)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C122(0.80)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C122(1.04)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C122(1.10)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C122(1.21)  LDD1663  [5]
 LDCM0462  CL7 HEK-293T C122(0.91)  LDD1665  [5]
 LDCM0464  CL71 HEK-293T C122(0.96)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C122(1.01)  LDD1668  [5]
 LDCM0467  CL74 HEK-293T C122(0.94)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C122(1.39); C251(1.04)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C122(1.26)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C122(0.95)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C122(0.92)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C122(1.23)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C122(0.85)  LDD1677  [5]
 LDCM0477  CL83 HEK-293T C122(1.07)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C122(1.28)  LDD1681  [5]
 LDCM0480  CL86 HEK-293T C122(0.87)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C122(0.81)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C122(0.91); C251(1.06)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C122(1.10)  LDD1686  [5]
 LDCM0485  CL90 HEK-293T C122(1.67)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C122(0.96)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C122(1.17)  LDD1690  [5]
 LDCM0490  CL95 HEK-293T C122(0.80)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C122(1.22)  LDD1694  [5]
 LDCM0493  CL98 HEK-293T C122(1.28)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C122(1.05)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C122(0.84)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C122(1.06)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C122(0.78)  LDD1631  [5]
 LDCM0022  KB02 22RV1 C122(2.05)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C122(2.79)  LDD2660  [1]
 LDCM0024  KB05 NCI-H1666 C122(2.30)  LDD3346  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Torsin-1A (TOR1A) ClpA/ClpB family O14656
Phytanoyl-CoA dioxygenase, peroxisomal (PHYH) PhyH family O14832
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Peroxisome assembly protein 26 (PEX26) Peroxin-26 family Q7Z412
Alpha-synuclein (SNCA) Synuclein family P37840
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-2-macroglobulin (A2M) Protease inhibitor I39 (alpha-2-macroglobulin) family P01023
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Methyl-CpG-binding protein 2 (MECP2) . P51608

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402