Details of the Target

General Information of Target

Target ID LDTP07545
Target Name Synaptic plasticity regulator PANTS (C22orf39)
Gene Name C22orf39
Gene ID 128977
Synonyms
Synaptic plasticity regulator PANTS; Plasticity-associated neural transcript short
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADGSGWQPPRPCEAYRAEWKLCRSARHFLHHYYVHGERPACEQWQRDLASCRDWEERRN
AEAQQSLCESERARVRAARKHILVWAPRQSPPPDWHLPLPQEKDE
Target Bioclass
Other
Family
UPF0545 family
Function
Negatively regulates long-term potentiation and modulates adult synaptic plasticity. Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites. Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses.
Uniprot ID
Q6P5X5
Ensemble ID
ENST00000399562.9
HGNC ID
HGNC:27012

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C105(3.82)  LDD2157  [1]
DBIA
 Probe Info  		C105(0.95)  LDD1492  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C105(1.23)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C105(1.01)  LDD1509  [2]
 LDCM0259  AC14 HEK-293T C105(0.99)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C105(1.08)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C105(1.02)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C105(1.01)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C105(1.18)  LDD1518  [2]
 LDCM0281  AC21 HEK-293T C105(1.32)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C105(1.14)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C105(0.96)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C105(1.16)  LDD1523  [2]
 LDCM0286  AC26 HEK-293T C105(1.05)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C105(1.38)  LDD1526  [2]
 LDCM0289  AC29 HEK-293T C105(1.04)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C105(1.42)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C105(1.03)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C105(0.84)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C105(1.06)  LDD1532  [2]
 LDCM0295  AC34 HEK-293T C105(0.92)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C105(1.21)  LDD1535  [2]
 LDCM0298  AC37 HEK-293T C105(1.18)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C105(1.22)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C105(1.16)  LDD1539  [2]
 LDCM0302  AC40 HEK-293T C105(1.03)  LDD1541  [2]
 LDCM0304  AC42 HEK-293T C105(1.08)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C105(1.40)  LDD1544  [2]
 LDCM0307  AC45 HEK-293T C105(1.24)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C105(1.16)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C105(1.04)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C105(1.50)  LDD1549  [2]
 LDCM0312  AC5 HEK-293T C105(1.03)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C105(0.98)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C105(1.40)  LDD1553  [2]
 LDCM0316  AC53 HEK-293T C105(1.32)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C105(0.95)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C105(1.04)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C105(0.99)  LDD1558  [2]
 LDCM0321  AC58 HEK-293T C105(1.07)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C105(1.16)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C105(1.10)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C105(1.08)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C105(1.01)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C105(0.96)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C105(1.05)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C105(1.37)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C105(1.14)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C105(1.12)  LDD1511  [2]
 LDCM0275  AKOS034007705 HEK-293T C105(1.25)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C105(0.92)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C105(1.15)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C105(1.08)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C105(0.93)  LDD1574  [2]
 LDCM0372  CL103 HEK-293T C105(0.80)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C105(1.12)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C105(0.93)  LDD1578  [2]
 LDCM0376  CL107 HEK-293T C105(0.94)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C105(1.00)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C105(0.98)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C105(1.19)  LDD1583  [2]
 LDCM0381  CL111 HEK-293T C105(0.92)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C105(1.06)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C105(0.75)  LDD1587  [2]
 LDCM0385  CL115 HEK-293T C105(1.22)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C105(1.09)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C105(0.79)  LDD1591  [2]
 LDCM0389  CL119 HEK-293T C105(0.83)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C105(1.03)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C105(1.17)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C105(0.83)  LDD1596  [2]
 LDCM0394  CL123 HEK-293T C105(0.93)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C105(1.10)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C105(0.97)  LDD1600  [2]
 LDCM0398  CL127 HEK-293T C105(0.84)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C105(0.90)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C105(1.18)  LDD1604  [2]
 LDCM0402  CL15 HEK-293T C105(1.04)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C105(0.77)  LDD1607  [2]
 LDCM0405  CL18 HEK-293T C105(1.26)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C105(1.58)  LDD1610  [2]
 LDCM0409  CL21 HEK-293T C105(0.97)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C105(1.12)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C105(1.08)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C105(1.29)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C105(0.69)  LDD1617  [2]
 LDCM0415  CL27 HEK-293T C105(1.29)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C105(1.13)  LDD1620  [2]
 LDCM0418  CL3 HEK-293T C105(0.66)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C105(0.98)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C105(1.48)  LDD1624  [2]
 LDCM0422  CL33 HEK-293T C105(1.37)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C105(1.26)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C105(1.00)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C105(1.12)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C105(0.69)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C105(0.82)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C105(0.84)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C105(1.44)  LDD1634  [2]
 LDCM0432  CL42 HEK-293T C105(1.11)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C105(1.55)  LDD1637  [2]
 LDCM0435  CL45 HEK-293T C105(1.19)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C105(0.95)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C105(1.42)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C105(1.17)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C105(0.80)  LDD1643  [2]
 LDCM0443  CL52 HEK-293T C105(1.29)  LDD1646  [2]
 LDCM0445  CL54 HEK-293T C105(1.06)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C105(1.26)  LDD1649  [2]
 LDCM0448  CL57 HEK-293T C105(1.28)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C105(1.31)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C105(1.11)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C105(0.87)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C105(1.19)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C105(0.77)  LDD1656  [2]
 LDCM0455  CL63 HEK-293T C105(0.69)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C105(1.49)  LDD1659  [2]
 LDCM0458  CL66 HEK-293T C105(1.18)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C105(1.23)  LDD1662  [2]
 LDCM0461  CL69 HEK-293T C105(1.42)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C105(1.11)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C105(1.20)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C105(1.42)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C105(1.52)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C105(0.79)  LDD1669  [2]
 LDCM0469  CL76 HEK-293T C105(1.03)  LDD1672  [2]
 LDCM0471  CL78 HEK-293T C105(0.93)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C105(1.53)  LDD1675  [2]
 LDCM0475  CL81 HEK-293T C105(1.12)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C105(1.25)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C105(1.25)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C105(1.43)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C105(0.78)  LDD1682  [2]
 LDCM0481  CL87 HEK-293T C105(1.14)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C105(1.10)  LDD1685  [2]
 LDCM0484  CL9 HEK-293T C105(1.03)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C105(0.95)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C105(1.21)  LDD1689  [2]
 LDCM0488  CL93 HEK-293T C105(1.24)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C105(1.18)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C105(1.20)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C105(1.05)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C105(0.84)  LDD1695  [2]
 LDCM0494  CL99 HEK-293T C105(0.67)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C105(0.80)  LDD1698  [2]
 LDCM0625  F8 Ramos C105(0.94)  LDD2187  [3]
 LDCM0572  Fragment10 Ramos C105(0.71)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C105(3.63)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C105(0.64)  LDD2191  [3]
 LDCM0576  Fragment14 Ramos C105(0.75)  LDD2193  [3]
 LDCM0579  Fragment20 Ramos C105(0.59)  LDD2194  [3]
 LDCM0580  Fragment21 Ramos C105(0.92)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C105(0.49)  LDD2196  [3]
 LDCM0586  Fragment28 Ramos C105(0.37)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C105(1.54)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C105(0.74)  LDD2200  [3]
 LDCM0590  Fragment32 Ramos C105(0.92)  LDD2201  [3]
 LDCM0468  Fragment33 HEK-293T C105(0.75)  LDD1671  [2]
 LDCM0566  Fragment4 Ramos C105(0.93)  LDD2184  [3]
 LDCM0610  Fragment52 Ramos C105(0.96)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C105(1.01)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C105(0.51)  LDD2186  [3]
 LDCM0571  Fragment9 Ramos C105(0.78)  LDD2188  [3]
 LDCM0022  KB02 HEK-293T C105(0.95)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C105(1.36)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C105(1.01)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) 3-beta-HSD family Q9H2F3
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Tensin-2 (TNS2) PTEN phosphatase protein family Q63HR2
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
Arylsulfatase A (ARSA) Sulfatase family P15289
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
MyoD family inhibitor (MDFI) MDFI family Q99750
Phospholipid scramblase 3 (PLSCR3) Phospholipid scramblase family Q9NRY6
Sorting nexin-32 (SNX32) Sorting nexin family Q86XE0
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
DNA-binding protein inhibitor ID-3 (ID3) . Q02535
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Beta-crystallin A2 (CRYBA2) Beta/gamma-crystallin family P53672
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Progranulin (GRN) Granulin family P28799
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin-associated protein 10-11 (KRTAP10-11) KRTAP type 10 family P60412
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 5-6 (KRTAP5-6) KRTAP type 5 family Q6L8G9
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
RIMS-binding protein 3A (RIMBP3) RIMBP family Q9UFD9
Calcium-binding protein 2 (CABP2) . Q9NPB3
Collagen alpha-1(VIII) chain (COL8A1) . P27658
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Melanoma-associated antigen 11 (MAGEA11) . P43364
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
von Willebrand factor C domain-containing protein 2-like (VWC2L) . B2RUY7

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578