Details of the Target

General Information of Target

Target ID LDTP07538
Target Name Nuclear factor related to kappa-B-binding protein (NFRKB)
Gene Name NFRKB
Gene ID 4798
Synonyms
INO80G; Nuclear factor related to kappa-B-binding protein; DNA-binding protein R kappa-B; INO80 complex subunit G
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQE
VLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEV
VKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRT
PEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLS
TTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLA
ALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKE
EPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAA
PNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLE
TKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRM
HGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEI
CELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFE
RIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPV
TPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPAS
SQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPA
TATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTS
APSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSI
TTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAA
DSPAKASSASAPSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASS
EAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSK
TVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSV
VTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVR
IQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ
Target Bioclass
Other
Family
NFRKB family
Subcellular location
Nucleus
Function
Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.
Uniprot ID
Q6P4R8
Ensemble ID
ENST00000446488.7
HGNC ID
HGNC:7802

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.M769I .
COLO678 Insertion: p.T941_A942insPP .
IGROV1 SNV: p.P103T .
Ishikawa (Heraklio) 02 ER Deletion: p.Q522RfsTer29 DBIA    Probe Info 
MCC13 SNV: p.A1024V
Substitution: p.S703A		 .
MFE296 SNV: p.G542D .
NALM6 Substitution: p.A247T .
NCIH1155 SNV: p.V577I DBIA    Probe Info 
NCIH3122 SNV: p.Q465Ter .
SKMEL24 Substitution: p.G773K .
SNU1 SNV: p.G294D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K148(4.53)  LDD0277  [1]
DBIA
 Probe Info  		C29(5.68)  LDD0209  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C29(0.95)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C601(1.10); C29(0.87)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C601(1.04); C29(1.02)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C601(0.97); C29(1.02)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C601(1.08); C29(1.06)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C29(0.94)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C29(0.99)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C601(1.09); C29(0.94)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C601(1.02); C29(1.08)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C601(1.01); C29(0.93)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C601(1.10); C29(1.08)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C601(1.23); C29(0.95)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C601(1.06); C29(1.02)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C29(0.89)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C601(1.15); C29(0.96)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C29(0.97)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C601(0.93); C29(0.96)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C601(1.01); C29(1.08)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C601(0.97); C29(1.13)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C601(1.06); C29(1.00)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C601(0.97); C29(1.07)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C601(1.00); C29(1.02)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C29(0.95)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C601(1.04); C29(0.98)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C29(0.99)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C601(1.02); C29(0.91)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C601(0.99); C29(1.08)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C601(1.06); C29(1.10)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C601(1.11); C29(1.00)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C601(1.08); C29(1.06)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C29(0.94)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C601(0.92); C29(0.99)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C601(1.20); C29(0.95)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C29(0.94)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C601(1.11); C29(1.05)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C601(1.02); C29(1.07)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C601(1.06); C29(1.14)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C601(1.08); C29(0.99)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C601(1.05); C29(1.07)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C29(1.05)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C601(1.12); C29(0.83)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C29(0.98)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C601(1.00); C29(0.96)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C601(1.03); C29(0.99)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C601(1.02); C29(1.01)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C601(0.96); C29(1.23)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C601(1.01); C29(0.96)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C601(1.08); C29(1.04)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C29(1.02)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C601(1.01); C29(0.95)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C29(1.11)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C601(1.01); C29(0.98)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C601(0.99); C29(1.01)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C601(1.04); C29(1.07)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C601(0.99); C29(1.01)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C601(1.15); C29(0.98)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C601(1.02); C29(1.11)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C29(0.98)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C601(1.03); C29(1.02)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C29(0.98)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C601(1.06); C29(0.91)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C601(1.02); C29(0.97)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C29(1.01)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C601(1.01); C29(0.87)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C601(0.95)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C601(1.04); C29(0.99)  LDD1572  [7]
 LDCM0370  CL101 HEK-293T C601(0.97)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C29(1.03)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C601(0.96); C29(1.00)  LDD1576  [7]
 LDCM0374  CL105 HEK-293T C601(1.04)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C29(1.00)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C601(0.90); C29(1.05)  LDD1580  [7]
 LDCM0378  CL109 HEK-293T C601(0.99)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C29(1.05)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C29(0.95)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C601(0.88); C29(0.98)  LDD1585  [7]
 LDCM0383  CL113 HEK-293T C601(1.06)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C29(0.94)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C601(0.90); C29(1.06)  LDD1589  [7]
 LDCM0387  CL117 HEK-293T C601(1.02)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C29(1.11)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C601(1.04); C29(1.09)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C601(1.04); C29(1.03)  LDD1594  [7]
 LDCM0392  CL121 HEK-293T C601(1.01)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C29(1.11)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C601(0.88); C29(1.03)  LDD1598  [7]
 LDCM0396  CL125 HEK-293T C601(1.06)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C29(1.07)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C601(1.08); C29(1.08)  LDD1602  [7]
 LDCM0400  CL13 HEK-293T C601(0.97)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C29(1.07)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C601(0.82); C29(1.06)  LDD1606  [7]
 LDCM0404  CL17 HEK-293T C29(0.97)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C601(0.99); C29(0.90)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C601(1.02); C29(1.02)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C29(1.05)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C601(0.98); C29(1.18)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C601(0.82); C29(0.98)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C601(1.05); C29(1.09)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C29(1.02)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C601(1.10); C29(1.04)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C601(0.93)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C29(0.96)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C601(0.91); C29(1.05)  LDD1619  [7]
 LDCM0417  CL29 HEK-293T C29(0.98)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C601(0.96); C29(0.96)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C601(1.08); C29(0.88)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C601(0.94); C29(1.01)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C601(1.12); C29(1.18)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C601(1.03); C29(0.97)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C601(0.97); C29(0.98)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C29(1.12)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C601(1.06); C29(1.01)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C601(0.93)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C601(0.87); C29(1.09)  LDD1632  [7]
 LDCM0431  CL41 HEK-293T C29(0.93)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C601(1.07); C29(0.89)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C601(1.08); C29(1.01)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C601(0.95); C29(1.09)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C601(1.06); C29(1.02)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C601(1.07); C29(0.94)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C29(1.04)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C601(1.06); C29(1.03)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C601(1.06)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C29(0.95)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C29(1.01)  LDD1645  [7]
 LDCM0444  CL53 HEK-293T C29(0.90)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C601(0.95); C29(0.91)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C601(0.98); C29(1.01)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C601(0.91); C29(1.13)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C601(1.01); C29(1.04)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C601(1.03); C29(1.10)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C29(1.04)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C601(1.10); C29(0.85)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C601(1.05); C29(0.97)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C601(1.01)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C29(1.13)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C601(0.89); C29(1.08)  LDD1658  [7]
 LDCM0457  CL65 HEK-293T C29(1.04)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C601(1.09); C29(1.06)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C601(1.12); C29(1.00)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C601(0.99); C29(1.24)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C601(1.13); C29(1.06)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C601(1.12); C29(1.02)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C601(1.17); C29(1.04)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C29(1.01)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C601(1.08); C29(0.96)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C601(1.01)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C29(1.05)  LDD1670  [7]
 LDCM0470  CL77 HEK-293T C29(0.96)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C601(0.97); C29(0.96)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C601(0.96); C29(0.99)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C601(1.08); C29(1.14)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C601(0.86); C29(1.01)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C601(1.10); C29(1.03)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C601(1.18); C29(1.01)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C29(0.93)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C601(0.80); C29(0.98)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C601(0.99)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C29(1.05)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C601(0.91); C29(1.01)  LDD1684  [7]
 LDCM0483  CL89 HEK-293T C29(0.97)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C601(1.04); C29(1.04)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C601(0.85); C29(0.81)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C601(1.13); C29(1.07)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C601(0.95); C29(1.00)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C601(1.12); C29(1.00)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C601(1.02); C29(1.11)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C29(0.96)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C601(1.11); C29(0.94)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C601(1.00)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C29(1.08)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C601(1.02); C29(1.08)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C601(0.85); C29(1.02)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C601(0.97); C29(1.04)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C29(0.96)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C29(1.01); C601(0.88)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C29(5.68)  LDD0209  [2]
 LDCM0024  KB05 IGR37 C512(1.99)  LDD3314  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) Peptidase C12 family Q9Y5K5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840