Details of the Target

General Information of Target

Target ID LDTP07325
Target Name Ankyrin repeat and SAM domain-containing protein 6 (ANKS6)
Gene Name ANKS6
Gene ID 203286
Synonyms
ANKRD14; PKDR1; SAMD6; Ankyrin repeat and SAM domain-containing protein 6; Ankyrin repeat domain-containing protein 14; SamCystin; Sterile alpha motif domain-containing protein 6; SAM domain-containing protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAA
AAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAAR
FGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQL
GLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGV
AQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHAL
KMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHG
WTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQ
VNKDKGRPSHQPPLPHSKVRQPWSIPVLPDDKGGLKSWWNRMSNRFRKLKLMQTLPRGLS
SNQPLPFSDEPEPALDSTMRAAPQDKTSRSALPDAAPVTKDNGPGSTRGEKEDTLLTTML
RNGAPLTRLPSDKLKAVIPPFLPPSSFELWSSDRSRTRHNGKADPMKTALPQRASRGHPV
GGGGTDTTPVRPVKFPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGS
IDNVLSQIAAQRKKAAGLLEQKPSHRSSPVGPAPGSSPSELPASPAGGSAPVGKKLETSK
RPPSGTSTTSKSTSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTG
ILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLKELGIKTDGSRQQILAAISELNAGKGRE
RQILQETIHNFHSSFESSASNTRAPGNSPCA
Target Bioclass
Other
Subcellular location
Cell projection, cilium
Function Required for renal function.
Uniprot ID
Q68DC2
Ensemble ID
ENST00000353234.5
HGNC ID
HGNC:26724

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S769G .
IGROV1 SNV: p.C268Y .
KMRC1 SNV: p.D573E .
KYSE150 SNV: p.R759W .
MDAMB468 SNV: p.A502P .
NCIH1048 SNV: p.G167D .
NCIH1975 SNV: p.Q355L .
RL952 SNV: p.A327V .
SW1783 SNV: p.R293Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C268(0.76)  LDD1507  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C268(0.76)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C268(1.13)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C268(1.04)  LDD1509  [1]
 LDCM0259  AC14 HEK-293T C268(1.09)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C268(1.18)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C268(0.87)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C268(0.93)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C268(1.20)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C268(1.10)  LDD1518  [1]
 LDCM0281  AC21 HEK-293T C268(0.91)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C268(1.02)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C268(1.01)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C268(1.10)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C268(1.05)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C268(1.09)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C268(1.31)  LDD1526  [1]
 LDCM0289  AC29 HEK-293T C268(0.90)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C268(1.07)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C268(1.07)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C268(1.08)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C268(0.88)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C268(1.16)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C268(1.17)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C268(1.06)  LDD1535  [1]
 LDCM0298  AC37 HEK-293T C268(0.84)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C268(0.99)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C268(1.15)  LDD1539  [1]
 LDCM0302  AC40 HEK-293T C268(0.97)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C268(0.96)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C268(1.02)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C268(1.06)  LDD1544  [1]
 LDCM0307  AC45 HEK-293T C268(0.66)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C268(0.99)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C268(1.03)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C268(0.86)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C268(0.83)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C268(0.88)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C268(1.02)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C268(1.11)  LDD1553  [1]
 LDCM0316  AC53 HEK-293T C268(0.92)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C268(1.05)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C268(1.18)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C268(0.94)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C268(1.05)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C268(1.07)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C268(1.01)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C268(1.00)  LDD1562  [1]
 LDCM0325  AC61 HEK-293T C268(0.83)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C268(1.10)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C268(1.18)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C268(0.92)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C268(0.99)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C268(0.92)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C268(0.89)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C268(0.95)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C268(1.04)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C268(1.21)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C268(1.06)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C268(1.18)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C268(1.15)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C268(1.44)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C268(1.08)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C268(1.31)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C268(1.32)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C268(0.90)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C268(1.10)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C268(0.85)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C268(0.94)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C268(1.08)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C268(1.14)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C268(0.91)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C268(0.79)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C268(1.20)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C268(1.49)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C268(0.81)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C268(1.14)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C268(1.04)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C268(1.39)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C268(0.81)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C268(0.89)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C268(0.90)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C268(1.03)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C268(1.17)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C268(1.00)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C268(1.01)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C268(0.74)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C268(1.76)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C268(0.88)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C268(1.12)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C268(0.89)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C268(1.44)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C268(0.85)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C268(1.09)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C268(1.06)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C268(1.10)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C268(1.19)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C268(1.34)  LDD1611  [1]
 LDCM0409  CL21 HEK-293T C268(1.58)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C268(1.00)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C268(1.00)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C268(1.06)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C268(1.19)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C268(1.10)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C268(0.95)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C268(1.20)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C268(0.97)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C268(1.01)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C268(1.07)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C268(1.09)  LDD1624  [1]
 LDCM0422  CL33 HEK-293T C268(0.92)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C268(0.98)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C268(0.91)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C268(1.09)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C268(1.15)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C268(1.29)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C268(1.06)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C268(1.07)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C268(0.94)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C268(1.07)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C268(1.03)  LDD1637  [1]
 LDCM0435  CL45 HEK-293T C268(0.99)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C268(0.85)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C268(1.00)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C268(1.00)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C268(1.23)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C268(1.02)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C268(1.53)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C268(1.09)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C268(1.07)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C268(1.31)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C268(1.24)  LDD1649  [1]
 LDCM0448  CL57 HEK-293T C268(1.20)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C268(0.91)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C268(0.95)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C268(1.25)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C268(0.91)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C268(0.94)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C268(1.11)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C268(0.86)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C268(0.97)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C268(0.95)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C268(1.10)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C268(1.07)  LDD1662  [1]
 LDCM0461  CL69 HEK-293T C268(0.78)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C268(0.88)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C268(0.96)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C268(1.08)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C268(0.98)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C268(1.11)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C268(1.23)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C268(0.96)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C268(0.99)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C268(1.05)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C268(1.14)  LDD1675  [1]
 LDCM0475  CL81 HEK-293T C268(0.84)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C268(1.07)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C268(1.02)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C268(1.08)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C268(1.20)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C268(1.07)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C268(1.23)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C268(1.11)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C268(0.83)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C268(0.73)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C268(1.21)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C268(1.09)  LDD1689  [1]
 LDCM0488  CL93 HEK-293T C268(0.68)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C268(1.11)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C268(1.08)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C268(1.01)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C268(1.14)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C268(1.13)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C268(0.89)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C268(0.98)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C268(0.85)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C268(1.22)  LDD1631  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) . Q9NX47
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 2 (BCL2L2) Bcl-2 family Q92843
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (STRIT1) . P0DN84
Transmembrane protein 60 (TMEM60) . Q9H2L4
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BET1 homolog (BET1) BET1 family O15155
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Syntaxin-7 (STX7) Syntaxin family O15400
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Complement C5 (C5) . P01031
Emerin (EMD) . P50402
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019